Disease relevance of Cldn4

• In the current studies, we used a C-terminal fragment of Clostridium perfringens enterotoxin (C-CPE) as a modulator of claudin-4 [1].
• CONCLUSION: Experimental obstructive jaundice increases claudin-4 expression in intestinal epithelium, which may be a key factor contributing to the disruption of the mucosal barrier [2].
• Administration of BBS or NT restored claudin-4 expression to the control state and significantly reduced portal and aortic endotoxemia [2].

High impact information on Cldn4

• Among differences in the gut are a crypt-to-villus decrease in claudin 2, a highly restricted expression of claudin 4 to colonic surface cells, and the finding that some claudins can be junctional, lateral, or show a gradient in junctional vs. lateral localization along the crypt-to-villus surface axis [3].
• These results suggest that C-CPE enhances the absorption of dextran in rat jejunum, apparently through interactions with claudin-4, and this effect may represent an effective novel strategy for enhancing the absorption of drugs [1].
• Claudin-3 and claudin-4 were also co-expressed by some alveolar epithelial cells adjacent to type II cells [4].
• By immunohistochemistry of adult rat lung sections, claudin-3, claudin-4, and claudin-5 were found to be co-expressed by type II alveolar epithelial cells [4].
• Aldosterone and tight junctions: modulation of claudin-4 phosphorylation in renal collecting duct cells [5].

Biological context of Cldn4

• Claudin-4 expression was significantly increased in the upper third of the villi in jaundiced rats and an upregulation of its lateral distribution was noted [2].

Anatomical context of Cldn4

• Tissue sections of the terminal ileum were examined histologically and immunohistochemically for evaluation of claudin-4 expression in intestinal epithelium [2].

Associations of Cldn4 with chemical compounds

• Endogenous claudin-4 abundance and cellular localization were unaltered by aldosterone [5].

Other interactions of Cldn4

• Experimental obstructive jaundice alters claudin-4 expression in intestinal mucosa: effect of bombesin and neurotensin [2].

References