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Gene Review

Cldn3  -  claudin 3

Mus musculus

Synonyms: AI182374, CPE-R 2, CPE-receptor 2, Claudin-3, Clostridium perfringens enterotoxin receptor 2, ...
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Disease relevance of Cldn3

  • Clostridium perfringens enterotoxin (CPE), a single approximately 35-kD polypeptide, was reported to specifically bind to claudin-3/RVP1 and claudin-4/CPE-R at its COOH-terminal half [1].
  • CONCLUSIONS.: Claudin-3 and claudin-4 receptors may offer promising targets for the use of CPE as a novel type-specific therapy against this highly aggressive and chemotherapy-resistant variant of endometrial cancer [2].
  • Finally, the in vivo therapeutic effect of sublethal doses of CPE was studied in SCID mouse xenografts harboring subcutaneous and intraperitoneal USPC that expressed claudin-3 and claudin-4 [2].

High impact information on Cldn3


Biological context of Cldn3

  • To observe TJs in live epithelial cellular sheets, green fluorescent protein (GFP) was fused to the N-terminus of claudin-3 (a major cell adhesion molecule of TJs), which was stably expressed at a level that was approximately 50% of that of endogenous claudin-3 in mouse Eph4 epithelial cells [6].
  • Using gene expression profiling, we recently identified high expression of the claudin-3 and claudin-4 receptors in a limited set of USPC [2].
  • The mouse homologs Cpetr1 and Cpetr2 were identified and mapped to the conserved syntenic region on mouse chromosome 5 [7].

Anatomical context of Cldn3


Associations of Cldn3 with chemical compounds

  • METHODS.: Claudin-3 and claudin-4 receptor expression was analyzed at the mRNA and protein levels in flash-frozen and formalin-fixed, paraffin-embedded tissue from 20 consecutive USPC patients [2].

Other interactions of Cldn3

  • Gene array experiments, together with protein expression analysis by immunoblotting, revealed a differential spatiotemporal distribution of several proteins associated with epithelial maturation and polarization, including intercellular junctional proteins (e.g., ZO-1, claudin-3, E-cadherin) and the subapical cytoskeletal/microvillar protein ezrin [10].
  • In the acini-like terminal buds of the treated glands, tight junction proteins of ZO-1 and claudin-3 delineated the lumen and the apical membrane protein aquaporin-5 accumulated at the luminal cell surfaces [11].

Analytical, diagnostic and therapeutic context of Cldn3


  1. Clostridium perfringens enterotoxin fragment removes specific claudins from tight junction strands: Evidence for direct involvement of claudins in tight junction barrier. Sonoda, N., Furuse, M., Sasaki, H., Yonemura, S., Katahira, J., Horiguchi, Y., Tsukita, S. J. Cell Biol. (1999) [Pubmed]
  2. Overexpression of claudin-3 and claudin-4 receptors in uterine serous papillary carcinoma: novel targets for a type-specific therapy using Clostridium perfringens enterotoxin (CPE). Santin, A.D., Bellone, S., Marizzoni, M., Palmieri, M., Siegel, E.R., McKenney, J.K., Hennings, L., Comper, F., Bandiera, E., Pecorelli, S. Cancer (2007) [Pubmed]
  3. Intraepithelial gammadelta(+) Lymphocytes Maintain the Integrity of Intestinal Epithelial Tight Junctions in Response to Infection. Dalton, J.E., Cruickshank, S.M., Egan, C.E., Mears, R., Newton, D.J., Andrew, E.M., Lawrence, B., Howell, G., Else, K.J., Gubbels, M.J., Striepen, B., Smith, J.E., White, S.J., Carding, S.R. Gastroenterology (2006) [Pubmed]
  4. Androgens regulate the permeability of the blood-testis barrier. Meng, J., Holdcraft, R.W., Shima, J.E., Griswold, M.D., Braun, R.E. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  5. Clostridium perfringens enterotoxin elicits rapid and specific cytolysis of breast carcinoma cells mediated through tight junction proteins claudin 3 and 4. Kominsky, S.L., Vali, M., Korz, D., Gabig, T.G., Weitzman, S.A., Argani, P., Sukumar, S. Am. J. Pathol. (2004) [Pubmed]
  6. A peculiar internalization of claudins, tight junction-specific adhesion molecules, during the intercellular movement of epithelial cells. Matsuda, M., Kubo, A., Furuse, M., Tsukita, S. J. Cell. Sci. (2004) [Pubmed]
  7. Genes for the CPE receptor (CPETR1) and the human homolog of RVP1 (CPETR2) are localized within the Williams-Beuren syndrome deletion. Paperna, T., Peoples, R., Wang, Y.K., Kaplan, P., Francke, U. Genomics (1998) [Pubmed]
  8. Expression patterns of claudin family of tight junction membrane proteins in developing mouse submandibular gland. Hashizume, A., Ueno, T., Furuse, M., Tsukita, S., Nakanishi, Y., Hieda, Y. Dev. Dyn. (2004) [Pubmed]
  9. Clostridium perfringens enterotoxin binds to the second extracellular loop of claudin-3, a tight junction integral membrane protein. Fujita, K., Katahira, J., Horiguchi, Y., Sonoda, N., Furuse, M., Tsukita, S. FEBS Lett. (2000) [Pubmed]
  10. Spatiotemporal regulation of morphogenetic molecules during in vitro branching of the isolated ureteric bud: toward a model of branching through budding in the developing kidney. Meyer, T.N., Schwesinger, C., Bush, K.T., Stuart, R.O., Rose, D.W., Shah, M.M., Vaughn, D.A., Steer, D.L., Nigam, S.K. Dev. Biol. (2004) [Pubmed]
  11. Hedgehog peptide promotes cell polarization and lumen formation in developing mouse submandibular gland. Hashizume, A., Hieda, Y. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  12. Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. Morita, K., Furuse, M., Fujimoto, K., Tsukita, S. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
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