High impact information on Synpr

• The deduced protein, named synaptoporin, displays 58% amino acid identity to synaptophysin, with highly conserved transmembrane segments, but a divergent cytoplasmic tail [1].
• Synaptoporin, a novel putative channel protein of synaptic vesicles [1].
• Differential expression of synaptophysin and synaptoporin mRNAs in the postnatal rat central nervous system [2].
• In the outer plexiform layer, synaptophysin was present in photoreceptor terminals, and synaptoporin was present in horizontal cells [3].
• The closely related synaptic vesicle membrane proteins synaptophysin and synaptoporin are abundant in the hippocampal formation of the adult rat [4].

Biological context of Synpr

• Its deduced amino acid sequence displays 97% and 81% identity with the synaptoporin of rat and chicken, respectively [5].
• This gene was mapped to the chromosome 3p14.3 by matching against the Human Genome Sequence Database. 16-tissue RT-PCR analysis shows that human synaptoporin is specifically expressed in the brain [5].

Anatomical context of Synpr

• This difference, observed in the earliest synaptic contacts in the postnatal hippocampus and persisting into adult life, suggests distinct functions of synaptoporin in these nerve terminals [4].
• Moreover, in the adult, synaptoporin is found exclusively in the mossy fibre terminals present in the hilar region of the dentate gyrus and the regio inferior of the cornu ammonis [4].
• However, the biosynthesis of synaptophysin and synaptoporin by granule and periglomerular neurons, olfactory bulb interneurons, occurred mainly postnatally [6].

Other interactions of Synpr

• The binding of synaptoporin, a closely related homolog of synaptophysin, to synaptobrevin changes in a similar manner during development [7].
• Synaptophysin and synaptoporin expression in the developing rat olfactory system [6].

Analytical, diagnostic and therapeutic context of Synpr

• Northern blot analysis and PCR amplification of RNA from different rat tissues indicate expression of synaptoporin transcripts in the CNS [1].
• Cloning and sequence analysis of the human cDNA encoding the synaptoporin (delta), a highly conservative synaptic vesicle protein [5].
• The distribution of synaptophysin and synaptoporin was examined in the adult rat and rabbit retina by using single- and double- labeling immunocytochemistry with conventional light microscopy and confocal laser scanning microscopy [3].

References