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Gene Review

SOX5  -  SRY (sex determining region Y)-box 5

Homo sapiens

Synonyms: L-SOX5, L-SOX5B, L-SOX5F, MGC35153, Transcription factor SOX-5
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High impact information on SOX5

  • Here we show that three known genes map within the newly determined shortest region of overlap of amplification (SROA): DAD-R, SOX5, and EKI1 [1].
  • We also demonstrate a decrease in mRNA levels of the transcriptional co-activators L-Sox5 and Sox6 upon ROCK inhibition and cytochalasin D [2].
  • The combination of SOX5, SOX6, and SOX9 (the SOX trio) provides signals sufficient for induction of permanent cartilage [3].
  • While KRAS2 and JAW1 map to the proximal border of the SROA, SOX5 maps centrally in the SROA [4].
  • In mouse, the long form of Sox5, L-Sox5, is co-expressed and interacts with Sox6; together, these two proteins appear to play a key role in chondrogenesis and myogenesis [5].

Biological context of SOX5


Anatomical context of SOX5

  • 1. In contrast to the mouse gene, the human SOX5 gene is expressed in a variety of human tissues, and different size transcripts are observed in adult testis and fetal brain [6].
  • Here, we show that the group D Sox transcription factors Sox5 and Sox6 jointly and cell-autonomously regulate several stages of oligodendrocyte development in the mouse spinal cord [8].
  • L-Sox5 and Sox6 are respectively induced coincident and after the expression of Bmpr1b in the prechondrogenic aggregate, and their activation correlates with the induction of Type II Collagen and Aggrecan genes in the differentiating cartilages [9].
  • CONCLUSIONS: L-Sox5, Sox6, and Sox9 play essential roles in chondrocyte differentiation and, thereby, in cartilage formation [10].


  1. Coamplification of DAD-R, SOX5, and EKI1 in human testicular seminomas, with specific overexpression of DAD-R, correlates with reduced levels of apoptosis and earlier clinical manifestation. Zafarana, G., Gillis, A.J., van Gurp, R.J., Olsson, P.G., Elstrodt, F., Stoop, H., Millán, J.L., Oosterhuis, J.W., Looijenga, L.H. Cancer Res. (2002) [Pubmed]
  2. RhoA/ROCK Signaling Regulates Chondrogenesis in a Context-dependent Manner. Woods, A., Beier, F. J. Biol. Chem. (2006) [Pubmed]
  3. The combination of SOX5, SOX6, and SOX9 (the SOX trio) provides signals sufficient for induction of permanent cartilage. Ikeda, T., Kamekura, S., Mabuchi, A., Kou, I., Seki, S., Takato, T., Nakamura, K., Kawaguchi, H., Ikegawa, S., Chung, U.I. Arthritis Rheum. (2004) [Pubmed]
  4. Identification of the critical region of 12p over-representation in testicular germ cell tumors of adolescents and adults. Mostert, M.C., Verkerk, A.J., van de Pol, M., Heighway, J., Marynen, P., Rosenberg, C., van Kessel, A.G., van Echten, J., de Jong, B., Oosterhuis, J.W., Looijenga, L.H. Oncogene (1998) [Pubmed]
  5. Identification and characterization of the human long form of Sox5 (L-SOX5) gene. Ikeda, T., Zhang, J., Chano, T., Mabuchi, A., Fukuda, A., Kawaguchi, H., Nakamura, K., Ikegawa, S. Gene (2002) [Pubmed]
  6. Cloning and characterization of SOX5, a new member of the human SOX gene family. Wunderle, V.M., Critcher, R., Ashworth, A., Goodfellow, P.N. Genomics (1996) [Pubmed]
  7. Use of differentiating adult stem cells (marrow stromal cells) to identify new downstream target genes for transcription factors. Ylöstalo, J., Smith, J.R., Pochampally, R.R., Matz, R., Sekiya, I., Larson, B.L., Vuoristo, J.T., Prockop, D.J. Stem Cells (2006) [Pubmed]
  8. SoxD Proteins Influence Multiple Stages of Oligodendrocyte Development and Modulate SoxE Protein Function. Stolt, C.C., Schlierf, A., Lommes, P., Hillg??rtner, S., Werner, T., Kosian, T., Sock, E., Kessaris, N., Richardson, W.D., Lefebvre, V., Wegner, M. Dev. Cell (2006) [Pubmed]
  9. Analysis of the molecular cascade responsible for mesodermal limb chondrogenesis: Sox genes and BMP signaling. Chimal-Monroy, J., Rodriguez-Leon, J., Montero, J.A., Gañan, Y., Macias, D., Merino, R., Hurle, J.M. Dev. Biol. (2003) [Pubmed]
  10. L-Sox5, Sox6 and Sox9 control essential steps of the chondrocyte differentiation pathway. Lefebvre, V., Behringer, R.R., de Crombrugghe, B. Osteoarthr. Cartil. (2001) [Pubmed]
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