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Gene Review

ETNK1  -  ethanolamine kinase 1

Homo sapiens

Synonyms: EKI, EKI 1, EKI1, Ethanolamine kinase 1, Nbla10396
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High impact information on ETNK1


Biological context of ETNK1


Associations of ETNK1 with chemical compounds


Other interactions of ETNK1

  • Whereas EKI1 maps close to the telomeric region of the SROA, DAD-R is the first gene at the centromeric region within the 12p amplicon [1].

Analytical, diagnostic and therapeutic context of ETNK1


  1. Coamplification of DAD-R, SOX5, and EKI1 in human testicular seminomas, with specific overexpression of DAD-R, correlates with reduced levels of apoptosis and earlier clinical manifestation. Zafarana, G., Gillis, A.J., van Gurp, R.J., Olsson, P.G., Elstrodt, F., Stoop, H., Millán, J.L., Oosterhuis, J.W., Looijenga, L.H. Cancer Res. (2002) [Pubmed]
  2. Overexpression of a mammalian ethanolamine-specific kinase accelerates the CDP-ethanolamine pathway. Lykidis, A., Wang, J., Karim, M.A., Jackowski, S. J. Biol. Chem. (2001) [Pubmed]
  3. Novel expression of equivocal messages containing both regions of choline/ethanolamine kinase and muscle type carnitine palmitoyltransferase I. Yamazaki, N., Shinohara, Y., Kajimoto, K., Shindo, M., Terada, H. J. Biol. Chem. (2000) [Pubmed]
  4. Serine regulates phosphatidylethanolamine biosynthesis in the hamster heart. McMaster, C.R., Choy, P.C. J. Biol. Chem. (1992) [Pubmed]
  5. Choline regulates phosphatidylethanolamine biosynthesis in isolated hamster heart. Zelinski, T.A., Choy, P.C. J. Biol. Chem. (1982) [Pubmed]
  6. Galactosemic cataractogenesis disrupts intracellular interactions and changes the substrate specificity of choline/ethanolamine kinase. Liu, Y., Ekambaram, M.C., Blum, P.S., Stimbert, C.D., Jernigan, H.M. Exp. Eye Res. (1998) [Pubmed]
  7. Lipid metabolism in germinating seeds. Purification of ethanolamine kinase from soya bean. Wharfe, J., Harwood, J.L. Biochim. Biophys. Acta (1979) [Pubmed]
  8. Phospholipid-metabolizing enzymes in Alzheimer's disease: increased lysophospholipid acyltransferase activity and decreased phospholipase A2 activity. Ross, B.M., Moszczynska, A., Erlich, J., Kish, S.J. J. Neurochem. (1998) [Pubmed]
  9. Ethanolaminosis. A newly recognized, generalized storage disease with cardiomegaly, cerebral dysfunction and early death. Vietor, K.W., Havsteen, B., Harms, D., Busse, H., Heyne, K. Eur. J. Pediatr. (1977) [Pubmed]
  10. Effect of dibutyryl cyclic AMP on lipid synthesis in Microsporum gypseum. Vaidya, S., Khuller, G.K. Biochim. Biophys. Acta (1988) [Pubmed]
  11. Isolation and characterization of the human liver ethanolamine kinase. Draus, E., Niefind, J., Vietor, K., Havsteen, B. Biochim. Biophys. Acta (1990) [Pubmed]
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