High impact information on ETNK1

• Here we show that three known genes map within the newly determined shortest region of overlap of amplification (SROA): DAD-R, SOX5, and EKI1 [1].
• Ethanolamine kinase (EKI) is the first committed step in phosphatidylethanolamine (PtdEtn) biosynthesis via the CDP-ethanolamine pathway [2].
• Novel expression of equivocal messages containing both regions of choline/ethanolamine kinase and muscle type carnitine palmitoyltransferase I [3].
• The reduction was a result of an inhibition of ethanolamine kinase activity by an elevated pool of intracellular serine [4].
• Although the formation of CDP-ethanolamine is regarded as the rate-limiting step for phosphatidylethanolamine biosynthesis, choline was found to inhibit ethanolamine kinase, but did not have any effect on phosphoethanolamine cytidylyltransferase [5].

Biological context of ETNK1

• Galactosemic cataractogenesis disrupts intracellular interactions and changes the substrate specificity of choline/ethanolamine kinase [6].
• Lipid metabolism in germinating seeds. Purification of ethanolamine kinase from soya bean [7].

Associations of ETNK1 with chemical compounds

• Brain activities of enzymes involved in de novo phospholipid synthesis (ethanolamine kinase, choline kinase, choline phosphotransferase, phosphoethanolamine cytidylyltransferase, and phosphocholine cytidylyltransferase) were either normal or only slightly altered [8].
• The properties of ethanolamine kinase in intact cataractous lenses from rats fed a 50% galactose diet for 7-14 days were intermediate between those of intact control lenses and those in lens homogenates [6].
• An increased renal excretion of ethanolamine, a greatly increased hepatic concentration of ethanolamine and diminished hepatic ethanolamine kinase activity could be demonstrated [9].
• Ethanolamine kinase has been purified to homogeneity from germinating soya bean (Glycine max L.) seeds [7].
• Increased activities of phosphatidic acid phosphatase, glycerol kinase, ethanolamine kinase and choline kinase in the presence of these additives supports the enhanced synthesis of phospholipids and suggests that lipid biosynthesis is being controlled by cAMP in M. gypseum [10].

Other interactions of ETNK1

• Whereas EKI1 maps close to the telomeric region of the SROA, DAD-R is the first gene at the centromeric region within the 12p amplicon [1].

Analytical, diagnostic and therapeutic context of ETNK1

• The molecular weight of the native enzyme determined by Superose 12 (FPLC) gel filtration was 87,000 +/- 4000 Da, suggesting that ethanolamine kinase in human liver consists of two chains of the same or almost the same molecular weight [11].

References