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Gene Review

Sox6  -  SRY (sex determining region Y)-box 6

Mus musculus

Synonyms: AI987981, SOX-LZ, Sox-6, Transcription factor SOX-6
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Disease relevance of Sox6


High impact information on Sox6


Biological context of Sox6


Anatomical context of Sox6


Associations of Sox6 with chemical compounds

  • Sox6 overexpression causes cellular aggregation and the neuronal differentiation of P19 embryonic carcinoma cells in the absence of retinoic acid [11].

Regulatory relationships of Sox6

  • Expression profile analysis of key transcription factors involved in chondrogenesis showed that overexpression of AP-2alpha maintained the expression of Sox9 but suppressed the expression of SoxS and Sox6 [12].
  • Sox6 thus enhances erythroid cell development at multiple levels and thereby ensures adequate production and quality of red blood cells [13].

Other interactions of Sox6


Analytical, diagnostic and therapeutic context of Sox6










  1. L-Sox5, Sox6 and Sox9 control essential steps of the chondrocyte differentiation pathway. Lefebvre, V., Behringer, R.R., de Crombrugghe, B. Osteoarthr. Cartil. (2001) [Pubmed]
  2. Sox6 is a candidate gene for p100H myopathy, heart block, and sudden neonatal death. Hagiwara, N., Klewer, S.E., Samson, R.A., Erickson, D.T., Lyon, M.F., Brilliant, M.H. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  3. Sox6 directly silences epsilon globin expression in definitive erythropoiesis. Yi, Z., Cohen-Barak, O., Hagiwara, N., Kingsley, P.D., Fuchs, D.A., Erickson, D.T., Epner, E.M., Palis, J., Brilliant, M.H. PLoS Genet. (2006) [Pubmed]
  4. The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. Akiyama, H., Chaboissier, M.C., Martin, J.F., Schedl, A., de Crombrugghe, B. Genes Dev. (2002) [Pubmed]
  5. Sox5 and Sox6 are needed to develop and maintain source, columnar, and hypertrophic chondrocytes in the cartilage growth plate. Smits, P., Dy, P., Mitra, S., Lefebvre, V. J. Cell Biol. (2004) [Pubmed]
  6. SOX6 controls dorsal progenitor identity and interneuron diversity during neocortical development. Azim, E., Jabaudon, D., Fame, R.M., Macklis, J.D. Nat. Neurosci. (2009) [Pubmed]
  7. The cell-intrinsic requirement of Sox6 for cortical interneuron development. Batista-Brito, R., Rossignol, E., Hjerling-Leffler, J., Denaxa, M., Wegner, M., Lefebvre, V., Pachnis, V., Fishell, G. Neuron. (2009) [Pubmed]
  8. A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene. Lefebvre, V., Li, P., de Crombrugghe, B. EMBO J. (1998) [Pubmed]
  9. Sox5 and Sox6 are required for notochord extracellular matrix sheath formation, notochord cell survival and development of the nucleus pulposus of intervertebral discs. Smits, P., Lefebvre, V. Development (2003) [Pubmed]
  10. The Sry-related HMG box-containing gene Sox6 is expressed in the adult testis and developing nervous system of the mouse. Connor, F., Wright, E., Denny, P., Koopman, P., Ashworth, A. Nucleic Acids Res. (1995) [Pubmed]
  11. Sox6 overexpression causes cellular aggregation and the neuronal differentiation of P19 embryonic carcinoma cells in the absence of retinoic acid. Hamada-Kanazawa, M., Ishikawa, K., Nomoto, K., Uozumi, T., Kawai, Y., Narahara, M., Miyake, M. FEBS Lett. (2004) [Pubmed]
  12. Negative regulation of chondrocyte differentiation by transcription factor AP-2alpha. Huang, Z., Xu, H., Sandell, L. J. Bone Miner. Res. (2004) [Pubmed]
  13. Sox6 cell-autonomously stimulates erythroid cell survival, proliferation, and terminal maturation and is thereby an important enhancer of definitive erythropoiesis during mouse development. Dumitriu, B., Patrick, M.R., Petschek, J.P., Cherukuri, S., Klingmuller, U., Fox, P.L., Lefebvre, V. Blood (2006) [Pubmed]
  14. Sox6 regulation of cardiac myocyte development. Cohen-Barak, O., Yi, Z., Hagiwara, N., Monzen, K., Komuro, I., Brilliant, M.H. Nucleic Acids Res. (2003) [Pubmed]
  15. Accelerated up-regulation of L-Sox5, Sox6, and Sox9 by BMP-2 gene transfer during murine fracture healing. Uusitalo, H., Hiltunen, A., Ahonen, M., Gao, T.J., Lefebvre, V., Harley, V., Kähäri, V.M., Vuorio, E. J. Bone Miner. Res. (2001) [Pubmed]
  16. Characterization of Solt, a novel SoxLZ/Sox6 binding protein expressed in adult mouse testis. Yamashita, A., Ito, M., Takamatsu, N., Shiba, T. FEBS Lett. (2000) [Pubmed]
  17. cDNA cloning of the Sry-related gene Sox6 from rat with tissue-specific expression. Narahara, M., Yamada, A., Hamada-Kanazawa, M., Kawai, Y., Miyake, M. Biol. Pharm. Bull. (2002) [Pubmed]
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