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Gene Review

Agpat2  -  1-acylglycerol-3-phosphate O...

Mus musculus

Synonyms: 1-AGP acyltransferase 2, 1-AGPAT 2, 1-acyl-sn-glycerol-3-phosphate acyltransferase beta, 1-acylglycerol-3-phosphate O-acyltransferase 2, 2510002J07Rik, ...
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Disease relevance of Agpat2


High impact information on Agpat2

  • We report several different mutations of the gene (AGPAT2) encoding 1-acylglycerol-3-phosphate O-acyltransferase 2 in 20 affected individuals from 11 pedigrees of diverse ethnicities showing linkage to chromosome 9q34 [4].
  • Inhibition of LPAAT-beta using small interfering RNA or selective inhibitors, CT32521 and CT32228, two small-molecule noncompetitive antagonists representing two different classes of chemical structures, induces apoptosis in human ovarian and endometrial cancer cell lines in vitro at pharmacologically tenable nanomolar concentrations [2].
  • LPAAT-beta was localized to the endoplasmic reticulum and overexpression was associated with redistribution of protein kinase C-alpha [2].
  • PURPOSE: Lysophosphatidic acid acyltransferase-beta (LPAAT-beta) is a transmembrane enzyme critical for the biosynthesis of phosphoglycerides whose product, phosphatidic acid, plays a key role in raf and AKT/mTor-mediated signal transduction [3].
  • Furthermore, the small-molecule inhibitors of LPAAT-beta are not cytotoxic to a number of normal cell types, including primary bone marrow progenitors, indicating a differential dependence of tumour cells on LPAAT-beta function [5].

Analytical, diagnostic and therapeutic context of Agpat2

  • Inhibition of LPAAT-beta also enhanced the survival of mice bearing ovarian tumor xenografts [2].


  1. Prevalence of mutations in AGPAT2 among human lipodystrophies. Magré, J., Delépine, M., Van Maldergem, L., Robert, J.J., Maassen, J.A., Meier, M., Panz, V.R., Kim, C.A., Tubiana-Rufi, N., Czernichow, P., Seemanova, E., Buchanan, C.R., Lacombe, D., Vigouroux, C., Lascols, O., Kahn, C.R., Capeau, J., Lathrop, M. Diabetes (2003) [Pubmed]
  2. Lysophosphatidic acid acyltransferase-beta is a prognostic marker and therapeutic target in gynecologic malignancies. Springett, G.M., Bonham, L., Hummer, A., Linkov, I., Misra, D., Ma, C., Pezzoni, G., Di Giovine, S., Singer, J., Kawasaki, H., Spriggs, D., Soslow, R., Dupont, J. Cancer Res. (2005) [Pubmed]
  3. Induction of apoptosis using inhibitors of lysophosphatidic acid acyltransferase-beta and anti-CD20 monoclonal antibodies for treatment of human non-Hodgkin's lymphomas. Pagel, J.M., Laugen, C., Bonham, L., Hackman, R.C., Hockenbery, D.M., Bhatt, R., Hollenback, D., Carew, H., Singer, J.W., Press, O.W. Clin. Cancer Res. (2005) [Pubmed]
  4. AGPAT2 is mutated in congenital generalized lipodystrophy linked to chromosome 9q34. Agarwal, A.K., Arioglu, E., De Almeida, S., Akkoc, N., Taylor, S.I., Bowcock, A.M., Barnes, R.I., Garg, A. Nat. Genet. (2002) [Pubmed]
  5. Lysophosphatidic acid acyltransferase-beta: a novel target for induction of tumour cell apoptosis. Bonham, L., Leung, D.W., White, T., Hollenback, D., Klein, P., Tulinsky, J., Coon, M., de Vries, P., Singer, J.W. Expert Opin. Ther. Targets (2003) [Pubmed]
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