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MeSH Review

Diabetes Mellitus, Lipoatrophic

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Disease relevance of Diabetes Mellitus, Lipoatrophic


High impact information on Diabetes Mellitus, Lipoatrophic


Chemical compound and disease context of Diabetes Mellitus, Lipoatrophic


Biological context of Diabetes Mellitus, Lipoatrophic


Anatomical context of Diabetes Mellitus, Lipoatrophic


Gene context of Diabetes Mellitus, Lipoatrophic


  1. Nuclear lamin A inhibits adipocyte differentiation: implications for Dunnigan-type familial partial lipodystrophy. Boguslavsky, R.L., Stewart, C.L., Worman, H.J. Hum. Mol. Genet. (2006) [Pubmed]
  2. Altered pre-lamin A processing is a common mechanism leading to lipodystrophy. Capanni, C., Mattioli, E., Columbaro, M., Lucarelli, E., Parnaik, V.K., Novelli, G., Wehnert, M., Cenni, V., Maraldi, N.M., Squarzoni, S., Lattanzi, G. Hum. Mol. Genet. (2005) [Pubmed]
  3. Structure of the globular tail of nuclear lamin. Dhe-Paganon, S., Werner, E.D., Chi, Y.I., Shoelson, S.E. J. Biol. Chem. (2002) [Pubmed]
  4. Multisystem dystrophy syndrome due to novel missense mutations in the amino-terminal head and alpha-helical rod domains of the lamin A/C gene. Garg, A., Speckman, R.A., Bowcock, A.M. Am. J. Med. (2002) [Pubmed]
  5. Köbberling type of familial partial lipodystrophy: an underrecognized syndrome. Herbst, K.L., Tannock, L.R., Deeb, S.S., Purnell, J.Q., Brunzell, J.D., Chait, A. Diabetes Care (2003) [Pubmed]
  6. Heterozygous missense mutations in BSCL2 are associated with distal hereditary motor neuropathy and Silver syndrome. Windpassinger, C., Auer-Grumbach, M., Irobi, J., Patel, H., Petek, E., Hörl, G., Malli, R., Reed, J.A., Dierick, I., Verpoorten, N., Warner, T.T., Proukakis, C., Van den Bergh, P., Verellen, C., Van Maldergem, L., Merlini, L., De Jonghe, P., Timmerman, V., Crosby, A.H., Wagner, K. Nat. Genet. (2004) [Pubmed]
  7. Lipoatrophic diabetes in Irs1(-/-)/Irs3(-/-) double knockout mice. Laustsen, P.G., Michael, M.D., Crute, B.E., Cohen, S.E., Ueki, K., Kulkarni, R.N., Keller, S.R., Lienhard, G.E., Kahn, C.R. Genes Dev. (2002) [Pubmed]
  8. Environmental modulation of atherosclerosis end points in familial hypercholesterolemia. Hegele, R.A. Atherosclerosis. Supplements. (2002) [Pubmed]
  9. Efficacy and safety of troglitazone in the treatment of lipodystrophy syndromes. Arioglu, E., Duncan-Morin, J., Sebring, N., Rother, K.I., Gottlieb, N., Lieberman, J., Herion, D., Kleiner, D.E., Reynolds, J., Premkumar, A., Sumner, A.E., Hoofnagle, J., Reitman, M.L., Taylor, S.I. Ann. Intern. Med. (2000) [Pubmed]
  10. Phenotypes of the N88S Berardinelli-Seip congenital lipodystrophy 2 mutation. Auer-Grumbach, M., Schlotter-Weigel, B., Lochmüller, H., Strobl-Wildemann, G., Auer-Grumbach, P., Fischer, R., Offenbacher, H., Zwick, E.B., Robl, T., Hartl, G., Hartung, H.P., Wagner, K., Windpassinger, C. Ann. Neurol. (2005) [Pubmed]
  11. Late-onset lipoatrophic diabetes. Phenotypic and genotypic familial studies and effect of treatment with metformin and lispro insulin analog. Vantyghem, M.C., Vigouroux, C., Magré, J., Desbois-Mouthon, C., Pattou, F., Fontaine, P., Lefebvre, J., Capeau, J. Diabetes Care (1999) [Pubmed]
  12. Improved glucose tolerance after effective lipid-lowering therapy with bezafibrate in a patient with lipoatrophic diabetes mellitus: a putative role for Randle's cycle in its pathogenesis? Panz, V.R., Wing, J.R., Raal, F.J., Kedda, M.A., Joffe, B.I. Clin. Endocrinol. (Oxf) (1997) [Pubmed]
  13. Long-term treatment experience in a subject with Dunnigan-type familial partial lipodystrophy: efficacy of rosiglitazone. Lüdtke, A., Heck, K., Genschel, J., Mehnert, H., Spuler, S., Worman, H.J., Schmidt, H.H. Diabet. Med. (2005) [Pubmed]
  14. Lipid metabolism in lipoatrophic diabetes. Enzi, G., Digito, M., Baldo-Enzi, G., Cominacini, L., Dodi, G., Carraro, R., Zurlo, F. Horm. Metab. Res. (1988) [Pubmed]
  15. Transgenic overexpression of leptin rescues insulin resistance and diabetes in a mouse model of lipoatrophic diabetes. Ebihara, K., Ogawa, Y., Masuzaki, H., Shintani, M., Miyanaga, F., Aizawa-Abe, M., Hayashi, T., Hosoda, K., Inoue, G., Yoshimasa, Y., Gavrilova, O., Reitman, M.L., Nakao, K. Diabetes (2001) [Pubmed]
  16. Phenotypic and genetic heterogeneity in congenital generalized lipodystrophy. Agarwal, A.K., Simha, V., Oral, E.A., Moran, S.A., Gorden, P., O'Rahilly, S., Zaidi, Z., Gurakan, F., Arslanian, S.A., Klar, A., Ricker, A., White, N.H., Bindl, L., Herbst, K., Kennel, K., Patel, S.B., Al-Gazali, L., Garg, A. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  17. A novel interaction between lamin A and SREBP1: implications for partial lipodystrophy and other laminopathies. Lloyd, D.J., Trembath, R.C., Shackleton, S. Hum. Mol. Genet. (2002) [Pubmed]
  18. The R482Q lamin A/C mutation that causes lipodystrophy does not prevent nuclear targeting of lamin A in adipocytes or its interaction with emerin. Holt, I., Clements, L., Manilal, S., Brown, S.C., Morris, G.E. Eur. J. Hum. Genet. (2001) [Pubmed]
  19. Membrane topology of the human seipin protein. Lundin, C., Nordström, R., Wagner, K., Windpassinger, C., Andersson, H., von Heijne, G., Nilsson, I. FEBS Lett. (2006) [Pubmed]
  20. Cell culture studies of a patient with congenital lipoatrophic diabetes--normal insulin binding with alterations in intracellular glucose metabolism and insulin action. Howard, B.V., Mott, D.M., Hidaka, H., Fields, R.M., Katzeff, H., Howard, W.J., Bennett, P.H. Metab. Clin. Exp. (1981) [Pubmed]
  21. PPARG F388L, a transactivation-deficient mutant, in familial partial lipodystrophy. Hegele, R.A., Cao, H., Frankowski, C., Mathews, S.T., Leff, T. Diabetes (2002) [Pubmed]
  22. Mutations in the seipin and AGPAT2 genes clustering in consanguineous families with Berardinelli-Seip congenital lipodystrophy from two separate geographical regions of Brazil. Gomes, K.B., Fernandes, A.P., Ferreira, A.C., Pardini, H., Garg, A., Magré, J., Pardini, V.C. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  23. Single nucleotide polymorphisms of RXRA encoding retinoid X receptor alpha. Hegele, R.A., Cao, H. J. Hum. Genet. (2001) [Pubmed]
  24. WY14,643, a peroxisome proliferator-activated receptor alpha (PPARalpha ) agonist, improves hepatic and muscle steatosis and reverses insulin resistance in lipoatrophic A-ZIP/F-1 mice. Chou, C.J., Haluzik, M., Gregory, C., Dietz, K.R., Vinson, C., Gavrilova, O., Reitman, M.L. J. Biol. Chem. (2002) [Pubmed]
  25. Molecular scanning of beta-3-adrenergic receptor gene in total congenital lipoatrophic diabetes mellitus. Silver, K., Walston, J., Plotnick, L., Taylor, S.I., Kahn, C.R., Shuldiner, A.R. J. Clin. Endocrinol. Metab. (1997) [Pubmed]
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