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Disease relevance of Pleurodeles


High impact information on Pleurodeles

  • FN has been detected at an early blastula stage in Pleurodeles waltlii [2].
  • Oocytes of several amphibian species (Xenopus laevis, Rana temporaria, and Pleurodeles waltlii) contained a relatively large pool of nonchromatin-bound, soluble high mobility group (HMG) protein with properties similar to those of calf thymus proteins HMG-1 and HMG-2 (protein HMG-A; A, amphibian) [3].
  • Sucrose gradient analysis permits discrimination between enzymes from axolotl and the sharp-ribbed salamander (Pleurodeles waltlii) for both heavy and light enzymatic forms of DNA ligase [4].
  • We isolated and characterized a sequence coding for heat-shock protein 70 (HSP70) of the amphibian Pleurodeles waltl [5].
  • Both cDNA clones encode Pleurodeles FGF receptors that share characteristics common to members of the FGF receptor superfamily [6].

Biological context of Pleurodeles


Anatomical context of Pleurodeles


Associations of Pleurodeles with chemical compounds

  • To investigate the function of alphav integrins during gastrulation, we have generated a function blocking antibody directed against the extracellular domain of the Pleurodeles integrin alphav subunit [16].
  • In the urodelan amphibian Pleurodeles waltlii, spontaneous anatomical metamorphosis was correlated with an increase in the serum level of thyroxine (T4) [17].
  • Comparative analysis of dopamine and tyrosine hydroxylase immunoreactivities in the brain of two amphibians, the anuran Rana ridibunda and the urodele Pleurodeles waltlii [18].
  • Characterization of Le(x), Le(y) and A Le(y) antigen determinants in KDN-containing O-linked glycan chains from Pleurodeles waltlii jelly coat eggs [19].
  • The role of the monoamine serotonin (5-HT) in modulating the neural networks underlying axial locomotor movements was studied in an adult amphibian urodele, Pleurodeles waltl [20].

Gene context of Pleurodeles


Analytical, diagnostic and therapeutic context of Pleurodeles


  1. Expression patterns of dystrophin products, especially of apodystrophin-1/Dp71, in the neural retina of Amphibian urodele Pleurodeles waltl. Arsanto, J.P., Caubit, X., Rivier, F., Hugon, G., Thouveny, Y., Mornet, D. Int. J. Dev. Biol. (1999) [Pubmed]
  2. Prevention of gastrulation but not neurulation by antibodies to fibronectin in amphibian embryos. Boucaut, J.C., Darribère, T., Boulekbache, H., Thiery, J.P. Nature (1984) [Pubmed]
  3. High mobility group proteins of amphibian oocytes: a large storage pool of a soluble high mobility group-1-like protein and involvement in transcriptional events. Kleinschmidt, J.A., Scheer, U., Dabauvalle, M.C., Bustin, M., Franke, W.W. J. Cell Biol. (1983) [Pubmed]
  4. Control of DNA ligase molecular forms in nucleocytoplasmic combinations of axolotl and Pleurodeles. Signoret, J., David, J.C., Lefresne, J., Houillon, C. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  5. Constitutive expression of a somatic heat-inducible hsp70 gene during amphibian oogenesis. Billoud, B., Rodriguez-Martin, M.L., Berard, L., Moreau, N., Angelier, N. Development (1993) [Pubmed]
  6. Differential expression and regulation of two distinct fibroblast growth factor receptors during early development of the urodele amphibian Pleurodeles waltl. Shi, D.L., Feige, J.J., Riou, J.F., DeSimone, D.W., Boucaut, J.C. Development (1992) [Pubmed]
  7. Female-enriched and thermosensitive expression of steroidogenic factor-1 during gonadal differentiation in Pleurodeles waltl. Kuntz, S., Chardard, D., Ko, C.I., Dumond, H., Ducatez, M., Callier, M., Flament, S., Chesnel, A. J. Mol. Endocrinol. (2006) [Pubmed]
  8. The recombination-activating gene 1 of Pleurodeles waltl (urodele amphibian) is transcribed in lymphoid tissues and in the central nervous system. Frippiat, C., Kremarik, P., Ropars, A., Dournon, C., Frippiat, J.P. Immunogenetics (2001) [Pubmed]
  9. Noggin upregulates Fos expression by a calcium-mediated pathway in amphibian embryos. Leclerc, C., Duprat, A.M., Moreau, M. Dev. Growth Differ. (1999) [Pubmed]
  10. Characterization of estrogen binding sites in the liver of the newt Pleurodeles waltl (Urodela:Amphibia): demonstration of a sex-linked heterogeneity. Dupont, H., Cayrol, C., Faye, J.C. J. Steroid Biochem. (1986) [Pubmed]
  11. There is an alpha-actin skeletal muscle-specific gene in a salamander (Pleurodeles waltlii). Khrestchatisky, M., Fontes, M. J. Mol. Biol. (1987) [Pubmed]
  12. Development of catecholamine systems in the central nervous system of the newt Pleurodeles waltlii as revealed by tyrosine hydroxylase immunohistochemistry. González, A., Marín, O., Smeets, W.J. J. Comp. Neurol. (1995) [Pubmed]
  13. Immunohistological localization of tenascin-C in the developing and regenerating retinotectal system of two amphibian species. Becker, T., Becker, C.G., Niemann, U., Naujoks-Manteuffel, C., Bartsch, U., Schachner, M., Roth, G. J. Comp. Neurol. (1995) [Pubmed]
  14. Comparison of three short-term assays: results on seven chemicals. Potential contribution to the control of water genotoxicity. Le Curieux, F., Marzin, D., Erb, F. Mutat. Res. (1993) [Pubmed]
  15. An alternative internal splicing site defines new Ikaros isoforms in Pleurodeles waltl. Boudarra, N., Frippiat, C., Dournon, C., Frippiat, J.P. Dev. Comp. Immunol. (2002) [Pubmed]
  16. A key function for alphav containing integrins in mesodermal cell migration during Pleurodeles waltl gastrulation. Skalski, M., Alfandari, D., Darribère, T. Dev. Biol. (1998) [Pubmed]
  17. Regulation by thyroid hormones of terminal differentiation in the skeletal dorsal muscle. II. Urodelan amphibians. Chanoine, C., d'Albis, A., Lenfant-Guyot, M., Janmot, C., Gallien, C.L. Dev. Biol. (1987) [Pubmed]
  18. Comparative analysis of dopamine and tyrosine hydroxylase immunoreactivities in the brain of two amphibians, the anuran Rana ridibunda and the urodele Pleurodeles waltlii. Gonzalez, A., Smeets, W.J. J. Comp. Neurol. (1991) [Pubmed]
  19. Characterization of Le(x), Le(y) and A Le(y) antigen determinants in KDN-containing O-linked glycan chains from Pleurodeles waltlii jelly coat eggs. Strecker, G., Wieruszeski, J.M., Michalski, J.C., Alonso, C., Boilly, B., Montreuil, J. FEBS Lett. (1992) [Pubmed]
  20. Serotonergic systems in the spinal cord of the amphibian urodele Pleurodeles waltl. Branchereau, P., Rodriguez, J.J., Delvolvé, I., Abrous, D.N., Le Moal, M., Cabelguen, J.M. J. Comp. Neurol. (2000) [Pubmed]
  21. Isolation and developmental expression of the amphibian homolog of the fibroblast growth factor receptor 3. Shi, D.L., Fromentoux, V., Launay, C., Umbhauer, M., Boucaut, J.C. J. Cell. Sci. (1994) [Pubmed]
  22. In vitro effect of metal ions on the activity of two amphibian glyceraldehyde-3-phosphate dehydrogenases: potential metal binding sites. Mounaji, K., Vlassi, M., Erraiss, N.E., Wegnez, M., Serrano, A., Soukri, A. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (2003) [Pubmed]
  23. A monoclonal antibody directed against quail tyrosine hydroxylase: description and use in immunocytochemical studies on differentiating neural crest cells. Fauquet, M., Ziller, C. J. Histochem. Cytochem. (1989) [Pubmed]
  24. Molecular cloning of a cDNA encoding the amphibian Pleurodeles waltl 70-kDa heat-shock cognate protein. Delelis-Fanien, C., Penrad-Mobayed, M., Angelier, N. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  25. Androgen and estrogen levels in the plasma of Pleurodeles waltl, Michah., during the annual cycle. I. Male cycle. Garnier, D.H. Gen. Comp. Endocrinol. (1985) [Pubmed]
  26. Patterns of dystrophin expression in developing, adult and regenerating tail skeletal muscle of Amphibian urodeles. Arsanto, J.P., Caubit, X., Fabbrizio, E., Léger, J., Mornet, D., Thouveny, Y. Int. J. Dev. Biol. (1992) [Pubmed]
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