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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Terms

 

Gene Review: 

Ddo  -  D-aspartate oxidase

Mus musculus

Synonyms: 5330420D20Rik, 5730402C02Rik, AI467244, DASOX, DDO
 
 
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High impact information on Ddo

  • Variable frequencies of V beta 2 T cells were observed among DDO individuals [1].
  • A physiological mechanism to regulate D-aspartic acid and NMDA levels in mammals revealed by D-aspartate oxidase deficient mice [2].
  • Mutated animals showed increased amounts of both D-aspartic acid and NMDA in all tissues examined demonstrating a physiological role of DDO in the regulation of their endogenous levels [2].
  • In vivo studies revealed that Quackenbush and DDO mice also share the same regenerative properties of mechanically damaged skeletal muscle as SJL/J mice [3].
  • Southern blotting indicated that SJL/J, Quackenbush and DDO mice share a Pax7/TaqI RFLP which differs from all other laboratory strains tested [3].
 

Biological context of Ddo

  • Since Quackenbush and DDO mice lack the SJL/J type of Myo-D1, and DDO belong to a different mouse sub-species, these studies suggest that structural alterations in the homeobox of a Pax7-like gene may be implicated in the effectiveness of renewal of damaged skeletal muscle of the limb in the mature animal [3].
  • Based on endogenous viral gene patterns the dd stock derived mice can be subdivided into three group, DDD, DDN, DDO, KF and DD/Tbr [4].
 

Anatomical context of Ddo

  • The Ddo(-/-) mice have D-aspartate immunoreactive cells in the cerebellum and adrenal glands that are not observed in the wild-type mice [5].
 

Associations of Ddo with chemical compounds

 

Other interactions of Ddo

References

  1. Identification of an endogenous mammary tumor virus involved in the clonal deletion of V beta 2 T cells. Jouvin-Marche, E., Marche, P.N., Six, A., Liebe-Gris, C., Voegtle, D., Cazenave, P.A. Eur. J. Immunol. (1993) [Pubmed]
  2. A physiological mechanism to regulate D-aspartic acid and NMDA levels in mammals revealed by D-aspartate oxidase deficient mice. Errico, F., Pirro, M.T., Affuso, A., Spinelli, P., De Felice, M., D'Aniello, A., Di Lauro, R. Gene (2006) [Pubmed]
  3. Association of an unusual form of a Pax7-like gene with increased efficiency of skeletal muscle regeneration. Kay, P.H., Mitchell, C.A., Akkari, A., Papadimitriou, J.M. Gene (1995) [Pubmed]
  4. Genetic marker patterns and endogenous mammary tumor virus genes in inbred mouse strains of Japan. Imai, S., Morimoto, J., Tsubura, Y., Esaki, K., Michalides, R., Holmes, R.S., von Deimling, O., Hilgers, J. Jikken Dobutsu (1986) [Pubmed]
  5. Behavioural alterations in male mice lacking the gene for D-aspartate oxidase. Weil, Z.M., Huang, A.S., Beigneux, A., Kim, P.M., Molliver, M.E., Blackshaw, S., Young, S.G., Nelson, R.J., Snyder, S.H. Behav. Brain Res. (2006) [Pubmed]
  6. Administration of D-aspartate increases D-aspartate oxidase activity in mouse liver. Yamada, R., Nagasaki, H., Nagata, Y., Wakabayashi, Y., Iwashima, A. Biochim. Biophys. Acta (1989) [Pubmed]
  7. D-aspartate oxidase activity and D-aspartate content in a mutant mouse strain lacking D-amino acid oxidase. Nagasaki, H., Yamada, R., Konno, R., Yasumura, Y., Iwashima, A. Experientia (1990) [Pubmed]
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