The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Dao  -  D-amino acid oxidase

Mus musculus

Synonyms: AI987963, D-amino-acid oxidase, DAAO, DAMOX, DAO, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Dao1


Psychiatry related information on Dao1


High impact information on Dao1


Biological context of Dao1


Anatomical context of Dao1


Associations of Dao1 with chemical compounds

  • Determination of free D-proline and D-leucine in the brains of mutant mice lacking D-amino acid oxidase activity [11].
  • In the brains of ddY/DAO- mice, D-leucine amounts are approximately 10 times higher than those obtained in ddY/DAO+ mice and regional difference has not been observed, while the amounts of L-proline and L-leucine are not significantly different between the two strains [11].
  • Amino acid levels in D-alanine-administered mutant mice lacking D-amino acid oxidase [14].
  • Urine from mutant mice lacking D-amino-acid oxidase contained a large amount of alanine compared with that from normal mice [15].
  • The normal increase in activity or rate of synthesis of beta-glucuronidase following androgen administration requires pituitary hormones and/or products of these hormones, while the increase in activity of enzymes like alcohol dehydrogenase and D-amino acid oxidase does not require pituitary hormones [16].

Other interactions of Dao1


Analytical, diagnostic and therapeutic context of Dao1


  1. Library screening for D-amino-acid oxidase gene: application of real-time PCR. Konno, R., Niwa, A. Amino Acids (2004) [Pubmed]
  2. Developmental aspects of polyamine-oxidizing enzyme activities in the mouse kidney. Effects of testosterone. Jotova, I., Pavlov, V., Dimitrov, O., Bachrach, U. Amino Acids (1999) [Pubmed]
  3. Spatial learning and long-term potentiation of mutant mice lacking D-amino-acid oxidase. Maekawa, M., Watanabe, M., Yamaguchi, S., Konno, R., Hori, Y. Neurosci. Res. (2005) [Pubmed]
  4. Reactions of cysteamine and other amine metabolites with glyoxylate and oxygen catalyzed by mammalian D-amino acid oxidase. Hamilton, G.A., Buckthal, D.J., Mortensen, R.M., Zerby, K.W. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  5. A monoclonal antibody recognizing the FAD-binding site of 4-aminobenzoate hydroxylase from Agaricus bisporus. Tsuji, H., Ogawa, T., Bando, N., Kimoto, M., Sasaoka, K. J. Biol. Chem. (1990) [Pubmed]
  6. Behavioral and biochemical characterization of a mutant mouse strain lacking D-amino acid oxidase activity and its implications for schizophrenia. Almond, S.L., Fradley, R.L., Armstrong, E.J., Heavens, R.B., Rutter, A.R., Newman, R.J., Chiu, C.S., Konno, R., Hutson, P.H., Brandon, N.J. Mol. Cell. Neurosci. (2006) [Pubmed]
  7. Intestinal bacterial origin of D-alanine in urine of mutant mice lacking D-amino-acid oxidase. Konno, R., Niwa, A., Yasumura, Y. Biochem. J. (1990) [Pubmed]
  8. Genetics of peroxisomal enzymes in the mouse: nonlinkage of D-amino acid oxidase locus (Dao) to catalase (Cs) and L-alpha-hydroxyacid oxidase (Hao-1) loci on chromosome 2. Holmes, R.S. Biochem. Genet. (1976) [Pubmed]
  9. Genetics and ontogeny of butyryl CoA dehydrogenase in the mouse and linkage of Bcd-1 with Dao-1. Seeley, T.L., Holmes, R.S. Biochem. Genet. (1981) [Pubmed]
  10. A single-base-pair substitution abolishes D-amino-acid oxidase activity in the mouse. Sasaki, M., Konno, R., Nishio, M., Niwa, A., Yasumura, Y., Enami, J. Biochim. Biophys. Acta (1992) [Pubmed]
  11. Determination of free D-proline and D-leucine in the brains of mutant mice lacking D-amino acid oxidase activity. Hamase, K., Inoue, T., Morikawa, A., Konno, R., Zaitsu, K. Anal. Biochem. (2001) [Pubmed]
  12. Free D-serine, D-aspartate and D-alanine in central nervous system and serum in mutant mice lacking D-amino acid oxidase. Hashimoto, A., Nishikawa, T., Konno, R., Niwa, A., Yasumura, Y., Oka, T., Takahashi, K. Neurosci. Lett. (1993) [Pubmed]
  13. Peroxisome development in the metanephric kidney of mouse. Goeckermann, J.A., Vigil, E.L. J. Histochem. Cytochem. (1975) [Pubmed]
  14. Amino acid levels in D-alanine-administered mutant mice lacking D-amino acid oxidase. Nagata, Y., Konno, R., Niwa, A. Metab. Clin. Exp. (1994) [Pubmed]
  15. Spontaneous excretion of D-alanine in urine in mutant mice lacking D-amino-acid oxidase. Konno, R., Nagata, Y., Niwa, A., Yasumura, Y. Biochem. J. (1989) [Pubmed]
  16. Differential effect of hypophysectomy on the synthesis of beta-glucuronidase and other androgen-inducible enzymes in mouse kidney. Swank, R.T., Davey, R., Joyce, L., Reid, P., Macey, M.R. Endocrinology (1977) [Pubmed]
  17. Early appearance of abnormality of microperoxisomal enzymes in the cerebral cortex of senescence-accelerated mouse. Sato, E., Kurokawa, T., Oda, N., Ishibashi, S. Mech. Ageing Dev. (1996) [Pubmed]
  18. Mice lacking D-amino acid oxidase activity display marked attenuation of stereotypy and ataxia induced by MK-801. Hashimoto, A., Yoshikawa, M., Niwa, A., Konno, R. Brain Res. (2005) [Pubmed]
  19. D-amino acid oxidase in mouse liver--II. Nagata, Y., Shimojo, T., Akino, T. Comp. Biochem. Physiol., B (1988) [Pubmed]
  20. D-aspartate oxidase activity and D-aspartate content in a mutant mouse strain lacking D-amino acid oxidase. Nagasaki, H., Yamada, R., Konno, R., Yasumura, Y., Iwashima, A. Experientia (1990) [Pubmed]
  21. Presence of D-amino-acid oxidase protein in mutant mice lacking D-amino-acid oxidase activity. Konno, R., Yamamoto, K., Niwa, A., Yasumura, Y. Int. J. Biochem. (1991) [Pubmed]
  22. Localization of D-amino acid oxidase mRNA in the mouse kidney and the effect of testosterone treatment. Koibuchi, N., Konno, R., Matsuzaki, S., Ohtake, H., Niwa, A., Yamaoka, S. Histochem. Cell Biol. (1995) [Pubmed]
  23. Excessive urinary excretion of methionine in mutant mice lacking D-amino-acid oxidase activity. Konno, R., Isobe, K., Niwa, A., Yasumura, Y. Metab. Clin. Exp. (1988) [Pubmed]
WikiGenes - Universities