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GRAP  -  GRB2-related adaptor protein

Homo sapiens

Synonyms: GRB2-related adapter protein
 
 
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Disease relevance of GRAP

  • GRAP repair is the favoured option for distal hypospadias and incorporates preservation of the prepuce [1].
 

High impact information on GRAP

  • Molecular characterization of a granulocyte macrophage-colony-stimulating factor receptor alpha subunit-associated protein, GRAP [2].
  • This interaction is mediated by the Grap SH2 domain, which has similar binding specificity to the Grb2 SH2 domain [3].
  • In Jurkat cells, T cell receptor activation leads to the association of Grap with phosphoproteins p36/38 and, to a lesser degree, Shc [3].
  • T cell activation effects an increase in Grap association with p36/38, Shc, Sos, and dynamin [3].
  • Based on the known functions of bound effector molecules, Grap-mediated responses to antigen challenge may include endocytosis of the T cell receptor, cellular proliferation, and regulated entry into the cell cycle [3].
 

Biological context of GRAP

 

Anatomical context of GRAP

  • Grap also forms a stable complex with the Bcr-Abl oncoprotein via its SH2 domain in K562 cells [4].
  • The single 2.3-kilobase (kb) grap transcript was expressed predominantly in thymus and spleen, while the ubiquitously expressed grb2 gene produced two mRNA species of 3.8 and 1.5 kb [4].
  • We conclude that Grap is a prominent component of lymphocyte receptor signaling [3].
 

Associations of GRAP with chemical compounds

  • Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway [4].
  • Furthermore, Grap is associated with a Ras guanine nucleotide exchange factor mSos1, primarily through its N-terminal SH3 domain [4].
 

Other interactions of GRAP

 

Analytical, diagnostic and therapeutic context of GRAP

References

  1. A prospective audit of hypospadias correction in a regional paediatric surgery centre. Heer, R., Dorkin, T.J., Byrne, R.L., Griffiths, T.R., Rangecroft, L. European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie. (2004) [Pubmed]
  2. Molecular characterization of a granulocyte macrophage-colony-stimulating factor receptor alpha subunit-associated protein, GRAP. Tu, J., Karasavvas, N., Heaney, M.L., Vera, J.C., Golde, D.W. Blood (2000) [Pubmed]
  3. The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signaling. Trüb, T., Frantz, J.D., Miyazaki, M., Band, H., Shoelson, S.E. J. Biol. Chem. (1997) [Pubmed]
  4. Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway. Feng, G.S., Ouyang, Y.B., Hu, D.P., Shi, Z.Q., Gentz, R., Ni, J. J. Biol. Chem. (1996) [Pubmed]
  5. A database of mutants and effects of site-directed mutagenesis experiments on G protein-coupled receptors. Kristiansen, K., Dahl, S.G., Edvardsen, O. Proteins (1996) [Pubmed]
  6. Leukocyte-specific adaptor protein Grap2 interacts with hematopoietic progenitor kinase 1 (HPK1) to activate JNK signaling pathway in T lymphocytes. Ma, W., Xia, C., Ling, P., Qiu, M., Luo, Y., Tan, T.H., Liu, M. Oncogene (2001) [Pubmed]
  7. Urinary excretion of the metabolites of n-hexane and its isomers during occupational exposure. Perbellini, L., Brugnone, F., Faggionato, G. British journal of industrial medicine. (1981) [Pubmed]
  8. Genomic organization and restricted expression of the human Mona/Gads gene suggests regulation by two specific promoters. Guyot, B., Arnaud, S., Phothirath, P., Bourette, R.P., Grasset, M.F., Rigal, D., Mouchiroud, G. Gene (2002) [Pubmed]
  9. Molecular cloning and expression of human grap-2, a novel leukocyte-specific SH2- and SH3-containing adaptor-like protein that binds to gab-1. Qiu, M., Hua, S., Agrawal, M., Li, G., Cai, J., Chan, E., Zhou, H., Luo, Y., Liu, M. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
 
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