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Gene Review

SVEP1  -  sushi, von Willebrand factor type A, EGF...

Homo sapiens

Synonyms: C9orf13, CCP module-containing protein 22, CCP22, FLJ13529, POLYDOM, ...
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Disease relevance of SVEP1

  • An increased amplitude of the SVEP F1 component with a tendency to the spread of visual reactivity was observed in juvenile migraine with and without aura; this pattern was not dissimilar from the one previously observed in adult migraine with and without aura [1].

High impact information on SVEP1


Biological context of SVEP1

  • The unusual composition of functional domains puts SEL-OB/SVEP1 in the discrete new group of membrane proteins involved in cell adhesion processes [3].
  • All together makes SEL-OB/SVEP1 an attractive marker for studying the role of stromal osteogenic cells and their interactions within the bone marrow microenvironment creating a network that regulates the skeletal homeostasis [3].
  • The chromosomal locations of two genes encoding the salivary protein products Simulidin (SVAT) and Simulium vittatum erythyma protein (SVEP) were identified using high-resolution cytogenetic mapping [4].

Anatomical context of SVEP1


Analytical, diagnostic and therapeutic context of SVEP1

  • Stromal osteogenic cells were analyzed for the protein expression using anti-SEL-OB/SVEP1 for immuno-precipitation and Western blot application confirm the presence of high molecular weight protein [3].


  1. EEG features in juvenile migraine: topographic analysis of spontaneous and visual evoked brain electrical activity: a comparison with adult migraine. Genco, S., de Tommaso, M., Prudenzano, A.M., Savarese, M., Puca, F.M. Cephalalgia : an international journal of headache. (1994) [Pubmed]
  2. SVEP1 expression is regulated in estrogen-dependent manner. Shur, I., Zemer-Tov, E., Socher, R., Benayahu, D. J. Cell. Physiol. (2007) [Pubmed]
  3. Molecular and cellular characterization of SEL-OB/SVEP1 in osteogenic cells in vivo and in vitro. Shur, I., Socher, R., Hameiri, M., Fried, A., Benayahu, D. J. Cell. Physiol. (2006) [Pubmed]
  4. Chromosomal localization of two antihemostatic salivary factors in Simulium vittatum (Diptera: Simuliidae). Procunier, W., Zhang, D., Cupp, M.S., Miller, M., Cupp, E.W. J. Med. Entomol. (2005) [Pubmed]
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