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Gene Review

WWC2  -  WW and C2 domain containing 2

Homo sapiens

Synonyms: BH-3-only member B, BOMB, FLJ22029, Protein WWC2, WW domain-containing protein 2
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Disease relevance of WWC2

  • Lung cancer mortality between 1950 and 1987 after exposure to fractionated moderate-dose-rate ionizing radiation in the Canadian fluoroscopy cohort study and a comparison with lung cancer mortality in the Atomic Bomb survivors study [1].
  • Among a total of 65,268 Nagasaki atomic bomb survivors recorded in the Scientific Data Center of Atomic Bomb Disaster, Nagasaki University School of Medicine, 140 cases with skin cancer were collected from 31 hospitals in Nagasaki City from 1961 through 1987 [2].

Psychiatry related information on WWC2

  • CONCLUSIONS: Bomb attack exposure resulted in persisting PTSD in a significant proportion of victims; the severity was predicted at 32 months by physical injuries and psychotropic drug use before the terrorism attack and by the PTSD score few months after the bomb attack [3].

High impact information on WWC2

  • Based on the Atomic Bomb Casualty Commission/Radiation Effects Research Foundation series of over 5,000 autopsies, we examined death certificate accuracy for 12 disease categories and assessed the effect of potential modifying factors on agreement and accuracy [4].
  • These observations demonstrate that human malaria parasite infection of mosquitoes is consistent with, and provides further support for, the Time Bomb model of ookinete invasion of the mosquito midgut epithelium previously proposed for rodent malaria parasites [5].
  • Physiologic concentrations of VIP, SOM, S-P and Bomb significantly suppressed thymidine incorporation into Con A-stimulated human LPL [6].
  • We studied the effect of VIP, SOM, S-P and Bomb on thymidine incorporation into human colonic lamina propria lymphocyte (LPL) DNA [6].
  • Time-of-travel calculations and tritium data showed ground water resides in these watersheds for decades. "Bomb-peak" precipitation (1963-1980) most influenced tritium concentrations near lower slope positions, while deep ground water was dominantly pre-1953 precipitation [7].

Biological context of WWC2

  • Therefore, one option is to begin evaluating statistics reported by a nontraditional public health data source, the U.S. Federal Bureau of Investigation (FBI) Bomb Data Center. METHODS: We reviewed data reported by the FBI Bomb Data Center for the years 1988-1997 and analyzed the number of bomb-related deaths and injuries and incidence of bombings [8].

Associations of WWC2 with chemical compounds

  • The two remaining algorithms include the "Suicide Bomb/Blast/Explosion" and the "Radiation Dispersal Device" algorithms, which are inter-connected through the overt pathway in the "Attack" algorithm [9].


  1. Lung cancer mortality between 1950 and 1987 after exposure to fractionated moderate-dose-rate ionizing radiation in the Canadian fluoroscopy cohort study and a comparison with lung cancer mortality in the Atomic Bomb survivors study. Howe, G.R. Radiat. Res. (1995) [Pubmed]
  2. Incidence of skin cancer among Nagasaki atomic bomb survivors (preliminary report). Sadamori, N., Mine, M., Hori, M., Fujiwara, N., Takahara, O., Nishimoto, K., Ota, H., Noda, Y., Namba, K., Sadamori, M. J. Radiat. Res. (1990) [Pubmed]
  3. Prediction of the occurrence and intensity of post-traumatic stress disorder in victims 32 months after bomb attack. Jehel, L., Paterniti, S., Brunet, A., Duchet, C., Guelfi, J.D. Eur. Psychiatry (2003) [Pubmed]
  4. Agreement between death certificate and autopsy diagnoses among atomic bomb survivors. Ron, E., Carter, R., Jablon, S., Mabuchi, K. Epidemiology (Cambridge, Mass.) (1994) [Pubmed]
  5. Plasmodium falciparum ookinete invasion of the midgut epithelium of Anopheles stephensi is consistent with the Time Bomb model. Baton, L.A., Ranford-Cartwright, L.C. Parasitology (2004) [Pubmed]
  6. Gastrointestinal neuropeptides suppress human colonic lamina propria lymphocyte DNA synthesis. Elitsur, Y., Luk, G.D. Peptides (1990) [Pubmed]
  7. Long-term effects of nitrogen fertilizer use on ground water nitrate in two small watersheds. Tomer, M.D., Burkart, M.R. J. Environ. Qual. (2003) [Pubmed]
  8. Investigation of Federal Bureau of Investigation bomb-related death and injury data in the United States between 1988 and 1997. Noji, E.K., Lee, C.Y., Davis, T., Peleg, K. Military medicine. (2005) [Pubmed]
  9. Symptom-based, algorithmic approach for handling the initial encounter with victims of a potential terrorist attack. Subbarao, I., Johnson, C., Bond, W.F., Schwid, H.A., Wasser, T.E., Deye, G.A., Burkhart, K.K. Prehospital and disaster medicine : the official journal of the National Association of EMS Physicians and the World Association for Emergency and Disaster Medicine in association with the Acute Care Foundation. (2005) [Pubmed]
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