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Gene Review

MOGAT2  -  monoacylglycerol O-acyltransferase 2

Homo sapiens

Synonyms: 2-acylglycerol O-acyltransferase 2, Acyl-CoA:monoacylglycerol acyltransferase 2, DC5, DGAT2L5, Diacylglycerol O-acyltransferase candidate 5, ...
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Disease relevance of MOGAT2

  • Finally, an up-regulation of both MGAT2 protein expression and MGAT activity was observed in mice fed a high fat diet, implicating a role of MGAT2 in diet-induced obesity [1].

High impact information on MOGAT2

  • Results demonstrate a high level of MGAT2 expression in the small intestine in a proximal-to-distal gradient that correlated well with both MGAT enzyme activity and fat absorption pattern [1].
  • MGAT2 is localized in the endoplasmic reticulum (ER) in both MGAT2-transfected COS-7 and Caco-2 cells, indicating that the ER is the primary site for dietary fat re-synthesis [1].
  • In contrast, MGAT2 protein was not detectable in other sections of the digestive tract, including stomach, cecum, colon, and rectum, or other mouse tissues such as kidney, liver, and adipocytes [1].
  • In addition to the small intestine, MGAT2 mRNA is also expressed at high levels in human liver, the lower gastrointestinal tract, and the mouse kidney, but the physiological significance of such expression has not yet been studied [1].
  • Acyl-CoA:monoacylglycerol acyltransferase-2 (MGAT2) catalyzes the synthesis of diacylglycerol and differs from the MGAT1 and MGAT3 in tissue distribution at the mRNA level [1].

Biological context of MOGAT2

  • MGAT2 expressed in mammalian cells can catalyze the acylation of rac-1-, sn-2-, and sn-3-monoacylglycerols, and the enzyme prefers monoacylglycerols containing unsaturated fatty acyls as substrates [2].

Anatomical context of MOGAT2

  • We also analyzed the biochemical features of MGAT2 and demonstrated homogenate protein-, time-, and substrate concentration-dependent MGAT enzyme activity in transiently transfected COS-7 cells [2].

Other interactions of MOGAT2

  • We report the cloning and initial characterization of the genes encoding DGAT2 (diacylglycerol transferase 2), MOGAT1 and MOGAT2 (monoacylglycerol transferases 1 and 2) in domestic cattle (Bos taurus) [3].

Analytical, diagnostic and therapeutic context of MOGAT2

  • Northern blot analysis indicates that the mouse MGAT2 is most abundantly expressed in the small intestine, suggesting that MGAT2 may play an important role in dietary fat absorption [2].


  1. A predominant role of acyl-CoA:monoacylglycerol acyltransferase-2 in dietary fat absorption implicated by tissue distribution, subcellular localization, and up-regulation by high fat diet. Cao, J., Hawkins, E., Brozinick, J., Liu, X., Zhang, H., Burn, P., Shi, Y. J. Biol. Chem. (2004) [Pubmed]
  2. Cloning and functional characterization of a mouse intestinal acyl-CoA:monoacylglycerol acyltransferase, MGAT2. Cao, J., Lockwood, J., Burn, P., Shi, Y. J. Biol. Chem. (2003) [Pubmed]
  3. Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos taurus) and other mammals. Winter, A., van Eckeveld, M., Bininda-Emonds, O.R., Habermann, F.A., Fries, R. Cytogenet. Genome Res. (2003) [Pubmed]
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