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Gene Review

DGAT2  -  diacylglycerol O-acyltransferase 2

Homo sapiens

Synonyms: ARAT, Acyl-CoA retinol O-fatty-acyltransferase, Diacylglycerol O-acyltransferase 2, Diglyceride acyltransferase 2, GS1999FULL, ...
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High impact information on DGAT2


Biological context of DGAT2


Anatomical context of DGAT2


Associations of DGAT2 with chemical compounds

  • These data suggest that niacin directly and noncompetitively inhibits DGAT2 but not DGAT1, resulting in decreased triglyceride synthesis and hepatic atherogenic lipoprotein secretion, thus indicating a major target site for its mechanism of action [8].
  • Niacin selectively inhibited DGAT2 but not DGAT1 activity [8].
  • Tung Tree DGAT1 and DGAT2 Have Nonredundant Functions in Triacylglycerol Biosynthesis and Are Localized to Different Subdomains of the Endoplasmic Reticulum [1].
  • Expression of DGAT1 and DGAT2 in yeast produced different types and proportions of TAGs containing eleostearic acid, with DGAT2 possessing an enhanced propensity for the synthesis of trieleostearin, the main component of tung oil [1].

Enzymatic interactions of DGAT2

  • There is still some debate whether there are three or four enzymes in yeast that have DGAT activity and catalyse the synthesis of TAG but of these the DGAT2 homologue Dga1 contributes in a major way to TAG biosynthesis [5].

Other interactions of DGAT2


Analytical, diagnostic and therapeutic context of DGAT2


  1. Tung Tree DGAT1 and DGAT2 Have Nonredundant Functions in Triacylglycerol Biosynthesis and Are Localized to Different Subdomains of the Endoplasmic Reticulum. Shockey, J.M., Gidda, S.K., Chapital, D.C., Kuan, J.C., Dhanoa, P.K., Bland, J.M., Rothstein, S.J., Mullen, R.T., Dyer, J.M. Plant Cell (2006) [Pubmed]
  2. Identification of two novel human acyl-CoA wax alcohol acyltransferases: members of the diacylglycerol acyltransferase 2 (DGAT2) gene superfamily. Turkish, A.R., Henneberry, A.L., Cromley, D., Padamsee, M., Oelkers, P., Bazzi, H., Christiano, A.M., Billheimer, J.T., Sturley, S.L. J. Biol. Chem. (2005) [Pubmed]
  3. Short-term overexpression of DGAT1 or DGAT2 increases hepatic triglyceride but not VLDL triglyceride or apoB production. Millar, J.S., Stone, S.J., Tietge, U.J., Tow, B., Billheimer, J.T., Wong, J.S., Hamilton, R.L., Farese, R.V., Rader, D.J. J. Lipid Res. (2006) [Pubmed]
  4. Colocalization of SCD1 and DGAT2: implying preference for endogenous monounsaturated fatty acids in triglyceride synthesis. Man, W.C., Miyazaki, M., Chu, K., Ntambi, J. J. Lipid Res. (2006) [Pubmed]
  5. Identification and functional expression of a type 2 acyl-CoA:diacylglycerol acyltransferase (DGAT2) in developing castor bean seeds which has high homology to the major triglyceride biosynthetic enzyme of fungi and animals. Kroon, J.T., Wei, W., Simon, W.J., Slabas, A.R. Phytochemistry (2006) [Pubmed]
  6. Increased diacylglycerol acyltransferase activity is associated with triglyceride accumulation in tissues of diet-induced insulin-resistant hyperlipidemic hamsters. Casaschi, A., Maiyoh, G.K., Adeli, K., Theriault, A.G. Metab. Clin. Exp. (2005) [Pubmed]
  7. Activation of diacylglycerol O-acyltransferase 1 gene results in increased tumor necrosis factor-alpha gene expression in 3T3-L1 adipocytes. Hirata, T., Unoki, H., Bujo, H., Ueno, K., Saito, Y. FEBS Lett. (2006) [Pubmed]
  8. Niacin noncompetitively inhibits DGAT2 but not DGAT1 activity in HepG2 cells. Ganji, S.H., Tavintharan, S., Zhu, D., Xing, Y., Kamanna, V.S., Kashyap, M.L. J. Lipid Res. (2004) [Pubmed]
  9. MEK-ERK inhibition corrects the defect in VLDL assembly in HepG2 cells: potential role of ERK in VLDL-ApoB100 particle assembly. Tsai, J., Qiu, W., Kohen-Avramoglu, R., Adeli, K. Arterioscler. Thromb. Vasc. Biol. (2007) [Pubmed]
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