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Gene Review

CDK5RAP3  -  CDK5 regulatory subunit associated protein 3

Homo sapiens

Synonyms: C53, CDK5 activator-binding protein C53, CDK5 regulatory subunit-associated protein 3, FLJ13660, HSF-27, ...
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Disease relevance of CDK5RAP3

  • In this study, we analyzed the presence of antibodies directed to HIV-1 gp160, gp120, gp41, and V3 loop synthetic peptides (C51, C53, and C57 from MN and IIIB strains) utilizing the grid-blot method in PBMC cultures of 52 mother-child pairs [1].

High impact information on CDK5RAP3


Biological context of CDK5RAP3

  • A novel gene IC53 stimulates ECV304 cell proliferation and is upregulated in failing heart [4].
  • We have identified IC53-2, a human homologue of the rat C53 gene from a human placenta cDNA library (GeneBank Accession No.AF217982) [5].
  • Stable transfection of IC53 stimulates ECV304 cell proliferation by 2.1-fold compared to cells with empty vector (P<0.05) [4].
  • The enzyme kinetics of the glutathione (GSH) conjugation of cryptophycin 52 (C52, R-stereoisomer) and cryptophycin 53 (C53, S-stereoisomer) by cytosolic glutathione S-transferases (cGSTs) from human, rat, mouse, dog and monkey liver were studied [6].

Anatomical context of CDK5RAP3


Associations of CDK5RAP3 with chemical compounds

  • Substrate metabolism (especially glucose metabolism) in C53-infected cells was partially reduced by treatment with ofloxacin [7].
  • C53 (delta 1-437) and C28 (delta 1-661) formed dimers irrespective of the presence or absence of 2-mercaptoethanol [8].

Other interactions of CDK5RAP3

  • Among these three proteins, only C48 and C53 can be phosphorylated by Nclk, suggesting that they may be the substrates of Nclk [9].
  • The full-length forms of these three novel proteins, designated C42, C48 and C53, have a molecular mass of 66, 24, and 57 kDa, respectively [9].

Analytical, diagnostic and therapeutic context of CDK5RAP3

  • In an antigen-limited ELISA, only two specimens from transmitting mothers and two specimens from non-transmitting mothers had detectable 'high-affinity' antibodies to C53 at low antigen concentrations (15.4 and 8.7%, respectively; P = 0.6) [10].
  • In this study, we have analysed the morphological consequences of infection of human DC by the attenuated S. typhimurium mutant strains designated PhoPc, AroA and SipB and the wild-type strains of the American Type Culture Collection (Manassas, VA, USA), ATCC 14028 and ATCC C53, by electron microscopy at 30 min, 3 h and 24 h after exposure [11].


  1. Correlation of maternal cytophilic human immunodeficiency virus (HIV)-1 V3 loop peptide-specific antibodies in infants with vertical HIV transmission. Wang, X.P., Oyaizu, N., Pahwa, S. Pediatr. Res. (1995) [Pubmed]
  2. The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization. Canet-Avilés, R.M., Wilson, M.A., Miller, D.W., Ahmad, R., McLendon, C., Bandyopadhyay, S., Baptista, M.J., Ringe, D., Petsko, G.A., Cookson, M.R. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  3. Cdk5 activator-binding protein C53 regulates apoptosis induced by genotoxic stress via modulating the G2/M DNA damage checkpoint. Jiang, H., Luo, S., Li, H. J. Biol. Chem. (2005) [Pubmed]
  4. A novel gene IC53 stimulates ECV304 cell proliferation and is upregulated in failing heart. Chen, J., Liu, B., Liu, Y., Han, Y., Yu, H., Zhang, Y., Lu, L., Zhen, Y., Hui, R. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  5. Cloning and characterization of human IC53-2, a novel CDK5 activator binding protein. Xie, Y.H., He, X.H., Tang, Y.T., Li, J.J., Pan, Z.M., Qin, W.X., Wan, d.a. .F., Gu, J.R. Cell Res. (2003) [Pubmed]
  6. In vitro metabolism of the epoxide substructure of cryptophycins by cytosolic glutathione S-transferase: species differences and stereoselectivity. Cannady, E.A., Chien, C., Jones, T.M., Borel, A.G. Xenobiotica (2006) [Pubmed]
  7. Effects of Salmonella typhimurium infection and ofloxacin treatment on glucose and glutamine metabolism in Caco-2/TC-7 cells. Posho, L., Delbos-Bocage, L., Gueylard, D., Farinotti, R., Carbon, C. Antimicrob. Agents Chemother. (1998) [Pubmed]
  8. The carboxyl-terminal region is essential for Sec-A dimerization. Hirano, M., Matsuyama, S., Tokuda, H. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  9. Cloning of three novel neuronal Cdk5 activator binding proteins. Ching, Y.P., Qi, Z., Wang, J.H. Gene (2000) [Pubmed]
  10. Lack of correlation between maternal antibodies to V3 loop peptides of gp120 and perinatal HIV-1 transmission. The NYC Perinatal HIV Transmission Collaborative Study. Parekh, B.S., Shaffer, N., Pau, C.P., Abrams, E., Thomas, P., Pollack, H., Bamji, M., Kaul, A., Schochetman, G., Rogers, M. AIDS (1991) [Pubmed]
  11. Host cell responses of Salmonella typhimurium infected human dendritic cells. Kiama, S.G., Dreher, D., Cochand, L., Kok, M., Obregon, C., Nicod, L., Gehr, P. Immunol. Cell Biol. (2006) [Pubmed]
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