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Gene Review

CDK5RAP2  -  CDK5 regulatory subunit associated protein 2

Homo sapiens

Synonyms: C48, CDK5 activator-binding protein C48, CDK5 regulatory subunit-associated protein 2, CEP215, Centrosome-associated protein 215, ...
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Disease relevance of CDK5RAP2

  • Transient response to imatinib in a chronic eosinophilic leukemia associated with ins(9;4)(q33;q12q25) and a CDK5RAP2-PDGFRA fusion gene [1].
  • Despite achieving complete cytogenetic and molecular remission on imatinib, the patient relapsed with imatinib-resistant acute myeloid leukemia that was characterized by a normal karyotype, absence of detectable CDK5RAP2-PDGFRA mRNA, and a newly acquired G12D NRAS mutation [1].
  • The Anabaena strain C48, containing the hetRc48a gene, could not produce HetR homodimer and failed to form heterocyst [2].
  • These results suggest that treatment with C48 may offer an effective immunotherapeutic means of controlling inflammatory polyarthritis [3].
  • C48 was injected intraperitoneally daily from day 3 to day 9 or from day 7 to day 13 after induction of synovitis by zymosan, and every other day from day 2 to day 14 after induction of AIA [3].

High impact information on CDK5RAP2

  • METHODS: The in vitro effect of PLIF/C48 was tested in mixed lymphocyte cultures (MLCs) of allogeneic mouse splenocytes [3].
  • C48 treatment reduced synovial lining thickening, numbers of mononuclear cells and histiocytes, as well as cartilage destruction and bone erosions [3].
  • DNA-gp3 packaging activity also required nucleotides G82 and G83 that form base pairs intermolecularly with C47 and C48 to produce a novel hexameric oligomer of pRNA [4].
  • The diene functionality comprising the remainder of the C44-C51 side chain was constructed by addition of an allylzinc reagent to the unmasked C48 aldehyde and subsequent dehydration of the resulting alcohol [5].
  • The cells were stimulated with a chemical release compound 48/80 (C48/80), and then histamine flowed into the lower layer, where it was derivatized to the fluorescent molecules with o-phthalaldehyde and its fluorescence was detected on the microchip [6].

Chemical compound and disease context of CDK5RAP2


Biological context of CDK5RAP2


Anatomical context of CDK5RAP2


Associations of CDK5RAP2 with chemical compounds

  • SP and SPD over the range of 10(-7) to 10(-4) M inhibited the release of 5-hydroxytryptamine (5-HT, serotonin) triggered by compound 48/80 (C48/80) in a time- and concentration-dependent manner, as long as at least 2% calf serum (CS) was present [15].
  • RESULTS: Histamine- and C48/80-induced protein extravasation was significantly lower in scalp skin [16].
  • Blockade of H1-receptors by cetirizine significantly reduced C48/80-induced protein extravasation in AD patients and controls to an identical level [8].
  • Pre-treatment of rice roots with neomycin and C48/80 abolished the anaerobic increase in the concentration of the PLC product inositol 1,4,5-triphosphate [17].
  • Both the CSF protein content and the CSF-to-serum albumin ratio correlated with C24 h/C5 h and C48 h/C24 h [18].

Other interactions of CDK5RAP2

  • Among these three proteins, only C48 and C53 can be phosphorylated by Nclk, suggesting that they may be the substrates of Nclk [11].

Analytical, diagnostic and therapeutic context of CDK5RAP2

  • Recombinant PLIF-C48 exhibited cell-mediated immunosuppression [12].
  • METHODS: Four microdialysis fibers were inserted intradermally into scalp (n = 10) or forearm skin (n = 10) of healthy male subjects and were perfused with histamine (0.01%) or compound 48/80 (C48/80; 0.05%) for 20 minutes [16].
  • 1. The lipoprotein triglycerides of human plasma can be separated by gas chromatography according to their carbon number into four main groups: C48, C50, C52 and C54 [19].
  • The study examined whether Shigyaku-san (Si-Ni-San) extract (TJ-35), a traditional Kampo medicine, prevents acute gastric mucosal lesion progression in rats treated once with compound 48/80 (C48/80) [20].


  1. Transient response to imatinib in a chronic eosinophilic leukemia associated with ins(9;4)(q33;q12q25) and a CDK5RAP2-PDGFRA fusion gene. Walz, C., Curtis, C., Schnittger, S., Schultheis, B., Metzgeroth, G., Schoch, C., Lengfelder, E., Erben, P., Müller, M.C., Haferlach, T., Hochhaus, A., Hehlmann, R., Cross, N.C., Reiter, A. Genes Chromosomes Cancer (2006) [Pubmed]
  2. HetR homodimer is a DNA-binding protein required for heterocyst differentiation, and the DNA-binding activity is inhibited by PatS. Huang, X., Dong, Y., Zhao, J. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  3. Placental immunomodulator ferritin, a novel immunoregulator, suppresses experimental arthritis. Weinberger, A., Halpern, M., Zahalka, M.A., Quintana, F., Traub, L., Moroz, C. Arthritis Rheum. (2003) [Pubmed]
  4. In vitro selection of bacteriophage phi29 prohead RNA aptamers for prohead binding. Zhang, F., Anderson, D. J. Biol. Chem. (1998) [Pubmed]
  5. Multigram synthesis of the C29-C51 subunit and completion of the total synthesis of altohyrtin C (spongistatin 2). Heathcock, C.H., McLaughlin, M., Medina, J., Hubbs, J.L., Wallace, G.A., Scott, R., Claffey, M.M., Hayes, C.J., Ott, G.R. J. Am. Chem. Soc. (2003) [Pubmed]
  6. Microbioassay system for antiallergic drug screening using suspension cells retaining in a poly(dimethylsiloxane) microfluidic device. Tokuyama, T., Fujii, S., Sato, K., Abo, M., Okubo, A. Anal. Chem. (2005) [Pubmed]
  7. Permutation of a pair of tertiary nucleotides in a transfer RNA. Hou, Y.M., Sterner, T., Jansen, M. Biochemistry (1995) [Pubmed]
  8. Mast cell mediators other than histamine induce pruritus in atopic dermatitis patients: a dermal microdialysis study. Rukwied, R., Lischetzki, G., McGlone, F., Heyer, G., Schmelz, M. Br. J. Dermatol. (2000) [Pubmed]
  9. Compound 48/80-induced conjunctivitis in the mouse: kinetics, susceptibility, and mechanism. Li, Q., Luyo, D., Hikita, N., Whitcup, S.M., Chan, C.C. Int. Arch. Allergy Immunol. (1996) [Pubmed]
  10. Molecular evolution of the brain size regulator genes CDK5RAP2 and CENPJ. Evans, P.D., Vallender, E.J., Lahn, B.T. Gene (2006) [Pubmed]
  11. Cloning of three novel neuronal Cdk5 activator binding proteins. Ching, Y.P., Qi, Z., Wang, J.H. Gene (2000) [Pubmed]
  12. Treatment of human bone marrow with recombinant placenta immunoregulator ferritin results in myelopoiesis and T-cell suppression through modulation of the cytokine-chemokine networks. Moroz, C., Grunspan, A., Zahalka, M.A., Traub, L., Kodman, Y., Yaniv, I. Exp. Hematol. (2006) [Pubmed]
  13. Brain mast cell degranulation regulates blood-brain barrier. Zhuang, X., Silverman, A.J., Silver, R. J. Neurobiol. (1996) [Pubmed]
  14. Effect of oral vitamin E administration on acute gastric mucosal lesion progression in rats treated with compound 48/80, a mast cell degranulator. Ohta, Y., Kobayashi, T., Imai, Y., Inui, K., Yoshino, J., Nakazawa, S. Biol. Pharm. Bull. (2006) [Pubmed]
  15. Inhibition of mast cell secretion by oxidation products of natural polyamines. Vliagoftis, H., Boucher, W.S., Mak, L.L., Theoharides, T.C. Biochem. Pharmacol. (1992) [Pubmed]
  16. Sensitivity of human scalp skin to pruritic stimuli investigated by intradermal microdialysis in vivo. Rukwied, R., Zeck, S., Schmelz, M., McGlone, F. J. Am. Acad. Dermatol. (2002) [Pubmed]
  17. Evidence for the involvement of phospholipase C in the anaerobic signal transduction. Reggiani, R., Laoreti, P. Plant Cell Physiol. (2000) [Pubmed]
  18. Inverse correlation between disappearance of intrathecally injected 111In-DTPA from CSF with CSF protein content and CSF-to-serum albumin ratio. Nau, R., Emrich, D., Prange, H.W. J. Neurol. Sci. (1993) [Pubmed]
  19. Decomposition of molecular types of triglycerides by lipoprotein lipase in man. Skorepa, J., Mares, P., Todorovicová, H. Acta Universitatis Carolinae. Medica. Monographia. (1977) [Pubmed]
  20. Preventive effect of Shigyaku-san on progression of acute gastric mucosal lesions induced by compound 48/80, a mast cell degranulator, in rats. Ohta, Y., Kobayashi, T., Hayashi, T., Inui, K., Yoshino, J., Nakazawa, S. Phytotherapy research : PTR. (2006) [Pubmed]
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