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Gene Review

CDH11  -  cadherin 11, type 2, OB-cadherin (osteoblast)

Homo sapiens

Synonyms: CAD11, CDHOB, Cadherin-11, OB, OB-cadherin, ...
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Disease relevance of CDH11


High impact information on CDH11

  • Human osteoblast cultures (hOB) were examined for the production of interstitial collagenase, tissue inhibitor of metalloproteinases (TIMP), and gelatinolytic enzymes [6].
  • SDS-substrate gel electrophoresis of hOB-conditioned media revealed a prominent band of gelatinolytic activity at 68 kD, and specific polyclonal antisera established its identity with the major gelatinolytic protease of human fibroblasts [6].
  • While overexpression of full-length classic cadherins, NCAD and CAD11, has no effect on LRN/ECN neuron migration, overexpression of two dominant negative (DN) constructs, membrane-bound form and cytoplasmic form, slows it down [7].
  • CDH11 is expressed strongly in bone, and our findings implicate a novel oncogenic mechanism in which deregulated USP6 transcription results from juxtaposition to the highly active CDH11 promoter [8].
  • Osteoblast (OB) differentiation is suppressed by tumor necrosis factor-alpha (TNF-alpha), an inflammatory stimulus that is elevated in arthritis and menopause [9].

Chemical compound and disease context of CDH11


Biological context of CDH11

  • The oncogenic mechanism in these fusion genes is akin to CDH11-USP6, with the USP6 coding sequences juxtaposed to the promoter regions in each of the four novel translocation partners [13].
  • IGF-I stimulation of hOB cell proliferation was markedly enhanced by pretreatment with TGF-beta and [Leu27]IGF-II, and this enhancement was prevented with protease-resistant IGFBP-4 [14].
  • Increased PAPP-A levels in hOB cell-conditioned medium paralleled PAPP-A gene expression [14].
  • Using semiquantitative reverse transcription followed by PCR, we found that PTHrP (107-139), between 10 nM and 1 pM, increased VEGF mRNA in human osteoblastic (hOB) cells from trabecular bone [15].
  • A new bone cell line was established by transfecting normal adult human osteoblast-like (hOB) cells, derived from a 68-year-old woman, with the plasmid pSV3 neo [16].

Anatomical context of CDH11

  • USP6 and CDH11 rearrangements were restricted to spindle cells in the ABC and were not found in multinucleated giant cells, inflammatory cells, endothelial cells, or osteoblasts [1].
  • The main findings point to novel molecules important in abnormal immune regulation and the highly disturbed cell biology of colonic epithelial cells in IBD pathogenesis, e.g., CYLD (cylindromatosis, turban tumor syndrome) and CDH11 (cadherin 11, type 2) [17].
  • Abundant secretion of gelatinolytic, but not collagenolytic, enzymes by hOB may indicate that human osteoblasts do not initiate and direct the cleavage of osteoid collagen on the bone surface, but may participate in the preparation of the bone surface for osteoclast attachment by removal of denatured collagen peptides [6].
  • Assay of activated T-cell CM on hOB revealed that a soluble factor, not cell-cell contact, was the major inducer of IL-6 [18].
  • Because of the lack of a practical procedure to isolate osteoblast precursors from early cultures of plastic adherent cells from bone marrow, previous studies of marrow stromal cells have been made in confluent cultures of bone marrow when the osteoblast (OB) precursors are already differentiated [19].

Associations of CDH11 with chemical compounds


Other interactions of CDH11


Analytical, diagnostic and therapeutic context of CDH11

  • This hypothesis was tested using a new bioassay that measures plasma mitogenic activity (PMA) for normal human osteoblast-like (hOB) cells [25].
  • MSUM and CPPD dose-dependently stimulated the production of PGE(2) in hOB as assessed by enzyme immunoassay, a response that was synergistically enhanced in the presence of IL-1 [3].
  • IGF-I mRNA expression was consistently observed in normal hOB cells only and by both RT-PCR and RPA [4].
  • We examined the effects of adding PN to cultured human osteoblast-like (hOB) cells obtained after hip arthroplasty [26].
  • Expression of nitrotyrosine by hOB, a marker of PN action, was significantly increased after SIN-1 addition, as compared with untreated cells, as revealed by Western blot analysis [26].


  1. USP6 and CDH11 oncogenes identify the neoplastic cell in primary aneurysmal bone cysts and are absent in so-called secondary aneurysmal bone cysts. Oliveira, A.M., Perez-Atayde, A.R., Inwards, C.Y., Medeiros, F., Derr, V., Hsi, B.L., Gebhardt, M.C., Rosenberg, A.E., Fletcher, J.A. Am. J. Pathol. (2004) [Pubmed]
  2. Anomalous cadherin expression in osteosarcoma. Possible relationships to metastasis and morphogenesis. Kashima, T., Kawaguchi, J., Takeshita, S., Kuroda, M., Takanashi, M., Horiuchi, H., Imamura, T., Ishikawa, Y., Ishida, T., Mori, S., Machinami, R., Kudo, A. Am. J. Pathol. (1999) [Pubmed]
  3. Inflammatory microcrystals alter the functional phenotype of human osteoblast-like cells in vitro: synergism with IL-1 to overexpress cyclooxygenase-2. Bouchard, L., de Médicis, R., Lussier, A., Naccache, P.H., Poubelle, P.E. J. Immunol. (2002) [Pubmed]
  4. Normal human osteoblast-like cells consistently express genes for insulin-like growth factors I and II but transformed human osteoblast cell lines do not. Okazaki, R., Conover, C.A., Harris, S.A., Spelsberg, T.C., Riggs, B.L. J. Bone Miner. Res. (1995) [Pubmed]
  5. GnRH analogs reduce invasiveness of human breast cancer cells. von Alten, J., Fister, S., Schulz, H., Viereck, V., Frosch, K.H., Emons, G., Gr??ndker, C. Breast Cancer Res. Treat. (2006) [Pubmed]
  6. Human osteoblasts in vitro secrete tissue inhibitor of metalloproteinases and gelatinase but not interstitial collagenase as major cellular products. Rifas, L., Halstead, L.R., Peck, W.A., Avioli, L.V., Welgus, H.G. J. Clin. Invest. (1989) [Pubmed]
  7. Classic cadherins regulate tangential migration of precerebellar neurons in the caudal hindbrain. Taniguchi, H., Kawauchi, D., Nishida, K., Murakami, F. Development (2006) [Pubmed]
  8. USP6 (Tre2) fusion oncogenes in aneurysmal bone cyst. Oliveira, A.M., Hsi, B.L., Weremowicz, S., Rosenberg, A.E., Dal Cin, P., Joseph, N., Bridge, J.A., Perez-Atayde, A.R., Fletcher, J.A. Cancer Res. (2004) [Pubmed]
  9. Transcriptional regulation of the Osterix (Osx, Sp7) promoter by tumor necrosis factor identifies disparate effects of mitogen-activated protein kinase and NFkappaB pathways. Lu, X., Gilbert, L., He, X., Rubin, J., Nanes, M.S. J. Biol. Chem. (2006) [Pubmed]
  10. Estrone sulfate is a major source of local estrogen formation in human bone. Muir, M., Romalo, G., Wolf, L., Elger, W., Schweikert, H.U. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  11. Role of polyunsaturated fatty acids in the inhibitory effect of human adipocytes on osteoblastic proliferation. Maurin, A.C., Chavassieux, P.M., Vericel, E., Meunier, P.J. Bone (2002) [Pubmed]
  12. Dexamethasone regulates IL-1 beta and TNF-alpha-induced interleukin-8 production in human bone marrow stromal and osteoblast-like cells. Chaudhary, L.R., Avioli, L.V. Calcif. Tissue Int. (1994) [Pubmed]
  13. Aneurysmal bone cyst variant translocations upregulate USP6 transcription by promoter swapping with the ZNF9, COL1A1, TRAP150, and OMD genes. Oliveira, A.M., Perez-Atayde, A.R., Dal Cin, P., Gebhardt, M.C., Chen, C.J., Neff, J.R., Demetri, G.D., Rosenberg, A.E., Bridge, J.A., Fletcher, J.A. Oncogene (2005) [Pubmed]
  14. Transforming growth factor-beta regulation of the insulin-like growth factor binding protein-4 protease system in cultured human osteoblasts. Ortiz, C.O., Chen, B.K., Bale, L.K., Overgaard, M.T., Oxvig, C., Conover, C.A. J. Bone Miner. Res. (2003) [Pubmed]
  15. C-terminal parathyroid hormone-related protein increases vascular endothelial growth factor in human osteoblastic cells. Esbrit, P., Alvarez-Arroyo, M.V., De Miguel, F., Martin, O., Martinez, M.E., Caramelo, C. J. Am. Soc. Nephrol. (2000) [Pubmed]
  16. Development and characterization of a rapidly proliferating, well-differentiated cell line derived from normal adult human osteoblast-like cells transfected with SV40 large T antigen. Keeting, P.E., Scott, R.E., Colvard, D.S., Anderson, M.A., Oursler, M.J., Spelsberg, T.C., Riggs, B.L. J. Bone Miner. Res. (1992) [Pubmed]
  17. Dissection of the inflammatory bowel disease transcriptome using genome-wide cDNA microarrays. Costello, C.M., Mah, N., Häsler, R., Rosenstiel, P., Waetzig, G.H., Hahn, A., Lu, T., Gurbuz, Y., Nikolaus, S., Albrecht, M., Hampe, J., Lucius, R., Klöppel, G., Eickhoff, H., Lehrach, H., Lengauer, T., Schreiber, S. PLoS Med. (2005) [Pubmed]
  18. A novel T cell cytokine stimulates interleukin-6 in human osteoblastic cells. Rifas, L., Avioli, L.V. J. Bone Miner. Res. (1999) [Pubmed]
  19. Isolation and characterization of osteoblast precursor cells from human bone marrow. Rickard, D.J., Kassem, M., Hefferan, T.E., Sarkar, G., Spelsberg, T.C., Riggs, B.L. J. Bone Miner. Res. (1996) [Pubmed]
  20. Direct action of naturally occurring estrogen metabolites on human osteoblastic cells. Robinson, J.A., Waters, K.M., Turner, R.T., Spelsberg, T.C. J. Bone Miner. Res. (2000) [Pubmed]
  21. Alendronate interacts with the inhibitory effect of 1,25(OH)2D3 on parathyroid hormone-related protein expression in human osteoblastic cells. Gómez-García, L., Esbrit, P., Carreño, L., Sabando, P., García-Flores, M., Martinez, M.E. J. Bone Miner. Res. (2003) [Pubmed]
  22. Characterization of aromatase and 17 beta-hydroxysteroid dehydrogenase expression in rat osteoblastic cells. Eyre, L.J., Bland, R., Bujalska, I.J., Sheppard, M.C., Stewart, P.M., Hewison, M. J. Bone Miner. Res. (1998) [Pubmed]
  23. Tumor necrosis factor alpha drives cadherin 11 expression in rheumatoid inflammation. Vandooren, B., Cantaert, T., ter Borg, M., Noordenbos, T., Kuhlman, R., Gerlag, D., Bongartz, T., Reedquist, K., Tak, P.P., Baeten, D. Arthritis Rheum. (2008) [Pubmed]
  24. E-cadherin and OB-cadherin mRNA levels in normal human colon and colon carcinoma. Munro, S.B., Turner, I.M., Farookhi, R., Blaschuk, O.W., Jothy, S. Exp. Mol. Pathol. (1995) [Pubmed]
  25. Role of hyperbilirubinemia in the impairment of osteoblast proliferation associated with cholestatic jaundice. Janes, C.H., Dickson, E.R., Okazaki, R., Bonde, S., McDonagh, A.F., Riggs, B.L. J. Clin. Invest. (1995) [Pubmed]
  26. Evidence that peroxynitrite affects human osteoblast proliferation and differentiation. da Rocha, F.A., de Brum-Fernandes, A.J. J. Bone Miner. Res. (2002) [Pubmed]
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