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Gene Review

OPR3  -  12-oxophytodienoate reductase 3

Arabidopsis thaliana

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High impact information on OPR3


Anatomical context of OPR3

  • The OPR3 protein and activity were consistently found in peroxisomes where they co-localize with the enzymes of beta-oxidation which catalyze the final steps in the formation of jasmonic acid [5].

Associations of OPR3 with chemical compounds

  • Thus, OPR3 is the isoenzyme relevant for jasmonate biosynthesis [6].
  • Transcripts of OPR3 rapidly accumulated in leaves after wounding and MeJA treatment, but they were detected in various tissues of unwounded plants at relatively low levels [7].
  • The recombinant OPR3 protein also showed beta-NADPH oxidation activity in the presence of cyclohexenone, but not cyclohexanone, suggesting that the enzyme has specificity to cleavage of olefinic bonds in cyclic enones [7].
  • The recombinant protein of OPR3 cross-reacted with an antiserum raised against the OYE protein, and showed oxidation of beta-NADPH when OPDA or 15-deoxy-delta(12,14) prostaglandin J2 (PGJ2), an analogue of OPDA, was used as substrate [7].
  • OPR3 was found to be induced by touch, wounding, methyl jasmonate (MeJA), NaCl and CaCl(2) while ethylene and darkness had no effect [8].

Other interactions of OPR3

  • The majority of genes (such as BRU1, CycD3, Lin6, OPR3, and TRIP-1) were identified by comparisons of BR-treated versus control-treated plants [9].

Analytical, diagnostic and therapeutic context of OPR3

  • Northern blot analysis of eight representative clones as probes confirmed low expression in opr3 anthers compared with wild-type anthers [10].


  1. Fatty acid-derived signals in plants. Weber, H. Trends Plant Sci. (2002) [Pubmed]
  2. Plant defense in the absence of jasmonic acid: the role of cyclopentenones. Stintzi, A., Weber, H., Reymond, P., Browse, J., Farmer, E.E. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  3. The Arabidopsis male-sterile mutant, opr3, lacks the 12-oxophytodienoic acid reductase required for jasmonate synthesis. Stintzi, A., Browse, J. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  4. Transcriptional regulators of stamen development in Arabidopsis identified by transcriptional profiling. Mandaokar, A., Thines, B., Shin, B., Markus Lange, B., Choi, G., Koo, Y.J., Yoo, Y.J., Choi, Y.D., Choi, G., Browse, J. Plant J. (2006) [Pubmed]
  5. Characterization and cDNA-microarray expression analysis of 12-oxophytodienoate reductases reveals differential roles for octadecanoid biosynthesis in the local versus the systemic wound response. Strassner, J., Schaller, F., Frick, U.B., Howe, G.A., Weiler, E.W., Amrhein, N., Macheroux, P., Schaller, A. Plant J. (2002) [Pubmed]
  6. 12-Oxophytodienoate reductase 3 (OPR3) is the isoenzyme involved in jasmonate biosynthesis. Schaller, F., Biesgen, C., Müssig, C., Altmann, T., Weiler, E.W. Planta (2000) [Pubmed]
  7. An Arabidopsis gene induced by wounding functionally homologous to flavoprotein oxidoreductases. Costa, C.L., Arruda, P., Benedetti, C.E. Plant Mol. Biol. (2000) [Pubmed]
  8. Use of differential display for the identification of touch-induced genes from an ethylene-insensitive Arabidopsis mutant and partial characterization of these genes. Chotikacharoensuk, T., Arteca, R.N., Arteca, J.M. J. Plant Physiol. (2006) [Pubmed]
  9. Brassinosteroid-regulated gene expression. Müssig, C., Fischer, S., Altmann, T. Plant Physiol. (2002) [Pubmed]
  10. Microarray and differential display identify genes involved in jasmonate-dependent anther development. Mandaokar, A., Kumar, V.D., Amway, M., Browse, J. Plant Mol. Biol. (2003) [Pubmed]
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