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Chemical Compound Review

PGJ2     (Z)-7-[(1R,5S)-5-[(E,3S)-3- hydroxyoct-1...

Synonyms: AC1NQXQ1, SureCN5700581, BSPBio_001498, CHEBI:27485, P6999_SIGMA, ...
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Disease relevance of prostaglandin J2


High impact information on prostaglandin J2


Biological context of prostaglandin J2

  • Although these agents fail to attenuate the inhibitory actions of PGJ2 on cytokine signaling, they do inhibit PGJ2-stimulated PPARgamma response element reporter activity [9].
  • M059K cells committed to undergo apoptosis by PGJ2, initially up-regulated PPARgamma, and then down-regulated PPARgamma as they began apoptosis [2].
  • A dose-dependent inhibition of TA 102 colony formation was also observed with 9-deoxy-delta 9-PGD2 between 0.01 to 1 microgram/ml, the IC50 value being 0.22 microgram/ml [3].
  • Induction of PPARgamma-dependent transactivation by 15-deoxy-Delta12,14-prostaglandin J2 (PGJ2) and DIM-C-pPhCF(3) was inhibited in MCF-7 cells cotreated with the PPARgamma-specific antagonist N-(4'-aminopyridyl)-2-chloro-5-nitrobenzamide [10].

Anatomical context of prostaglandin J2


Associations of prostaglandin J2 with other chemical compounds


Gene context of prostaglandin J2


  1. Depot-specific prostaglandin synthesis in human adipose tissue: A novel possible mechanism of adipogenesis. Quinkler, M., Bujalska, I.J., Tomlinson, J.W., Smith, D.M., Stewart, P.M. Gene (2006) [Pubmed]
  2. The PPARgamma ligands PGJ2 and rosiglitazone show a differential ability to inhibit proliferation and to induce apoptosis and differentiation of human glioblastoma cell lines. Morosetti, R., Servidei, T., Mirabella, M., Rutella, S., Mangiola, A., Maira, G., Mastrangelo, R., Koeffler, H.P. Int. J. Oncol. (2004) [Pubmed]
  3. The effects of PGD2 and 9-deoxy-delta 9-PGD2 on colony formation of murine osteosarcoma cells. Tanaka, H., Yamamuro, T., Matsumoto, M., Kotoura, Y., Tanaka, C. Prostaglandins (1985) [Pubmed]
  4. The effect of PPARgamma ligands on the proliferation and apoptosis of human melanoma cells. Placha, W., Gil, D., Dembińska-Kieć, A., Laidler, P. Melanoma Res. (2003) [Pubmed]
  5. Inhibition of human melanoma growth by prostaglandin A, D, and J analogues. Bregman, M.D., Funk, C., Fukushima, M. Cancer Res. (1986) [Pubmed]
  6. Urothelial differentiation in chronically urine-deprived bladders of patients with end-stage renal disease. Stahlschmidt, J., Varley, C.L., Toogood, G., Selby, P.J., Southgate, J. Kidney Int. (2005) [Pubmed]
  7. Suppression of arachidonic acid cascade-mediated apoptosis in aflatoxin B1-induced rat hepatoma cells by glucocorticoids. Iida, N., Sugiyama, A., Myoubudani, H., Inoue, K., Sugamata, M., Ihara, T., Ueno, Y., Tashiro, F. Carcinogenesis (1998) [Pubmed]
  8. Agonists of peroxisome proliferator-activated receptor-gamma attenuate the Abeta-mediated impairment of LTP in the hippocampus in vitro. Costello, D.A., O'Leary, D.M., Herron, C.E. Neuropharmacology (2005) [Pubmed]
  9. PPARgamma is not required for the inhibitory actions of PGJ2 on cytokine signaling in pancreatic beta-cells. Weber, S.M., Scarim, A.L., Corbett, J.A. Am. J. Physiol. Endocrinol. Metab. (2004) [Pubmed]
  10. A new class of peroxisome proliferator-activated receptor gamma (PPARgamma) agonists that inhibit growth of breast cancer cells: 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes. Qin, C., Morrow, D., Stewart, J., Spencer, K., Porter, W., Smith, R., Phillips, T., Abdelrahim, M., Samudio, I., Safe, S. Mol. Cancer Ther. (2004) [Pubmed]
  11. Inverse relationship between the expression of messenger ribonucleic acid for peroxisome proliferator-activated receptor gamma and P450 side chain cleavage in the rat ovary. Komar, C.M., Curry, T.E. Biol. Reprod. (2003) [Pubmed]
  12. Modulation of lymphocyte and monocyte responses in vitro by 9-deoxy-delta 9-prostaglandin D2 and 9-deoxy-delta 9-delta 12-prostaglandin D2. Petrini, B., Wasserman, J., Hammarström, S., Blomgren, H., Vedin, I. Int. Arch. Allergy Appl. Immunol. (1988) [Pubmed]
  13. On the identification and biological properties of prostaglandin J2. Mahmud, I., Smith, D.L., Whyte, M.A., Nelson, J.T., Cho, D., Tokes, L.G., Alvarez, R., Willis, A.L. Prostaglandins, leukotrienes, and medicine. (1984) [Pubmed]
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