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Gene Review

ATH1  -  homeobox protein ATH1

Arabidopsis thaliana

Synonyms: F26P21.100, F26P21_100, homeobox gene 1
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Disease relevance of ATH1


High impact information on ATH1

  • A correlation between the strength of the cop1 allele and the ATH1 mRNA level was found [2].
  • Expression of ATH1 does not require the presence of active chloroplasts because photooxidative destruction of the chloroplast by norflurazon treatment did not influence the ATH1 mRNA level [2].
  • A light-regulated Arabidopsis thaliana homeobox 1 gene (ATH1) was identified in a transcription factor gene collection [2].
  • The effect of the 2-h SA treatment on gene expression was measured using Affymetrix ATH1 arrays, and SA-induced genes were found to be significantly over-represented among genes neighboring putative TGA2-binding sites [3].
  • We measured immediate-early and delayed cytokinin responses through genome-wide expression profiling with the Affymetrix ATH1 full genome array (Affymetrix Inc., Santa Clara, CA, USA) [4].

Biological context of ATH1


Associations of ATH1 with chemical compounds


Regulatory relationships of ATH1

  • Since other floral repressors of the FLC clade are not significantly affected by ATH1, we conclude that ATH1 controls floral competency as a specific activator of FLC expression [14].

Other interactions of ATH1


Analytical, diagnostic and therapeutic context of ATH1

  • The CATMA array consists of gene-specific sequence tags of 150 to 500 bp, the Agilent (Arabidopsis 2) array of 60mer oligonucleotides, and the Affymetrix gene chip (ATH1) of 25mer oligonucleotide sets [19].


  1. Suppression of RNA silencing by a geminivirus nuclear protein, AC2, correlates with transactivation of host genes. Trinks, D., Rajeswaran, R., Shivaprasad, P.V., Akbergenov, R., Oakeley, E.J., Veluthambi, K., Hohn, T., Pooggin, M.M. J. Virol. (2005) [Pubmed]
  2. The homeobox gene ATH1 of Arabidopsis is derepressed in the photomorphogenic mutants cop1 and det1. Quaedvlieg, N., Dockx, J., Rook, F., Weisbeek, P., Smeekens, S. Plant Cell (1995) [Pubmed]
  3. Development of Arabidopsis whole-genome microarrays and their application to the discovery of binding sites for the TGA2 transcription factor in salicylic acid-treated plants. Thibaud-Nissen, F., Wu, H., Richmond, T., Redman, J.C., Johnson, C., Green, R., Arias, J., Town, C.D. Plant J. (2006) [Pubmed]
  4. Immediate-early and delayed cytokinin response genes of Arabidopsis thaliana identified by genome-wide expression profiling reveal novel cytokinin-sensitive processes and suggest cytokinin action through transcriptional cascades. Brenner, W.G., Romanov, G.A., Köllmer, I., Bürkle, L., Schmülling, T. Plant J. (2005) [Pubmed]
  5. Transcriptional changes in powdery mildew infected wheat and Arabidopsis leaves undergoing syringolin-triggered hypersensitive cell death at infection sites. Michel, K., Abderhalden, O., Bruggmann, R., Dudler, R. Plant Mol. Biol. (2006) [Pubmed]
  6. Genome-wide reprogramming of metabolism and regulatory networks of Arabidopsis in response to phosphorus. Morcuende, R., Bari, R., Gibon, Y., Zheng, W., Pant, B.D., Bl??sing, O., Usadel, B., Czechowski, T., Udvardi, M.K., Stitt, M., Scheible, W.R. Plant Cell Environ. (2007) [Pubmed]
  7. Analysis of the root-hair morphogenesis transcriptome reveals the molecular identity of six genes with roles in root-hair development in Arabidopsis. Jones, M.A., Raymond, M.J., Smirnoff, N. Plant J. (2006) [Pubmed]
  8. Molecular events in senescing Arabidopsis leaves. Lin, J.F., Wu, S.H. Plant J. (2004) [Pubmed]
  9. Genomic survey of gene expression diversity in Arabidopsis thaliana. Kliebenstein, D.J., West, M.A., van Leeuwen, H., Kim, K., Doerge, R.W., Michelmore, R.W., St Clair, D.A. Genetics (2006) [Pubmed]
  10. Microarray analysis of nitric oxide responsive transcripts in Arabidopsis. Parani, M., Rudrabhatla, S., Myers, R., Weirich, H., Smith, B., Leaman, D.W., Goldman, S.L. Plant Biotechnol. J. (2004) [Pubmed]
  11. Microarray analysis of the nitrate response in Arabidopsis roots and shoots reveals over 1,000 rapidly responding genes and new linkages to glucose, trehalose-6-phosphate, iron, and sulfate metabolism. Wang, R., Okamoto, M., Xing, X., Crawford, N.M. Plant Physiol. (2003) [Pubmed]
  12. Rapid array mapping of circadian clock and developmental mutations in Arabidopsis. Hazen, S.P., Borevitz, J.O., Harmon, F.G., Pruneda-Paz, J.L., Schultz, T.F., Yanovsky, M.J., Liljegren, S.J., Ecker, J.R., Kay, S.A. Plant Physiol. (2005) [Pubmed]
  13. Transcriptional regulators of stamen development in Arabidopsis identified by transcriptional profiling. Mandaokar, A., Thines, B., Shin, B., Markus Lange, B., Choi, G., Koo, Y.J., Yoo, Y.J., Choi, Y.D., Choi, G., Browse, J. Plant J. (2006) [Pubmed]
  14. The Arabidopsis TALE homeobox gene ATH1 controls floral competency through positive regulation of FLC. Proveniers, M., Rutjens, B., Brand, M., Smeekens, S. Plant J. (2007) [Pubmed]
  15. DNA array analyses of Arabidopsis thaliana lacking a vacuolar Na+/H+ antiporter: impact of AtNHX1 on gene expression. Sottosanto, J.B., Gelli, A., Blumwald, E. Plant J. (2004) [Pubmed]
  16. Interaction of the BELL-like protein ATH1 with DNA: role of homeodomain residue 54 in specifying the different binding properties of BELL and KNOX proteins. Viola, I.L., Gonzalez, D.H. Biol. Chem. (2006) [Pubmed]
  17. The Arabidopsis homeobox gene, ATHB16, regulates leaf development and the sensitivity to photoperiod in Arabidopsis. Wang, Y., Henriksson, E., Söderman, E., Henriksson, K.N., Sundberg, E., Engström, P. Dev. Biol. (2003) [Pubmed]
  18. Structure and expression of the Arabidopsis thaliana homeobox gene Athb-12. Lee, Y.H., Oh, H.S., Cheon, C.I., Hwang, I.T., Kim, Y.J., Chun, J.Y. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  19. Benchmarking the CATMA microarray. A novel tool for Arabidopsis transcriptome analysis. Allemeersch, J., Durinck, S., Vanderhaeghen, R., Alard, P., Maes, R., Seeuws, K., Bogaert, T., Coddens, K., Deschouwer, K., Van Hummelen, P., Vuylsteke, M., Moreau, Y., Kwekkeboom, J., Wijfjes, A.H., May, S., Beynon, J., Hilson, P., Kuiper, M.T. Plant Physiol. (2005) [Pubmed]
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