The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Cyclopentenone     cyclopent-2-en-1-one

Synonyms: PubChem9803, CHEMBL52190, SureCN24628, AGN-PC-00KGFC, AG-C-09668, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Cyclopentenone


Psychiatry related information on Cyclopentenone


High impact information on Cyclopentenone


Chemical compound and disease context of Cyclopentenone


Biological context of Cyclopentenone


Anatomical context of Cyclopentenone


Associations of Cyclopentenone with other chemical compounds


Gene context of Cyclopentenone


Analytical, diagnostic and therapeutic context of Cyclopentenone


  1. Inhibition of HIV-1 replication by cyclopentenone prostaglandins in acutely infected human cells. Evidence for a transcriptional block. Rozera, C., Carattoli, A., De Marco, A., Amici, C., Giorgi, C., Santoro, M.G. J. Clin. Invest. (1996) [Pubmed]
  2. 15-Deoxy-Delta(12,14)-prostaglandin J(2): the endogenous electrophile that induces neuronal apoptosis. Kondo, M., Shibata, T., Kumagai, T., Osawa, T., Shibata, N., Kobayashi, M., Sasaki, S., Iwata, M., Noguchi, N., Uchida, K. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  3. Essential role for hematopoietic prostaglandin D2 synthase in the control of delayed type hypersensitivity. Trivedi, S.G., Newson, J., Rajakariar, R., Jacques, T.S., Hannon, R., Kanaoka, Y., Eguchi, N., Colville-Nash, P., Gilroy, D.W. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  4. The cyclopentenone 15-deoxy-delta(12,14)-prostaglandin J2 inhibits G1/S transition and retinoblastoma protein phosphorylation in immortalized lymphocytes from Alzheimer's disease patients. Muñoz, U., de Las Cuevas, N., Bartolomé, F., Hermida, O.G., Bermejo, F., Martín-Requero, A. Exp. Neurol. (2005) [Pubmed]
  5. Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase. Rossi, A., Kapahi, P., Natoli, G., Takahashi, T., Chen, Y., Karin, M., Santoro, M.G. Nature (2000) [Pubmed]
  6. Asymmetric catalytic hydrogenation. Design of new Ru catalysts and chiral ligands: from laboratory to industrial applications. Genet, J.P. Acc. Chem. Res. (2003) [Pubmed]
  7. The cyclopentenone 15-deoxy-delta 12,14-prostaglandin J2 binds to and activates H-Ras. Oliva, J.L., Pérez-Sala, D., Castrillo, A., Martínez, N., Cañada, F.J., Boscá, L., Rojas, J.M. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  8. Activation of I kappa b kinase by herpes simplex virus type 1. A novel target for anti-herpetic therapy. Amici, C., Belardo, G., Rossi, A., Santoro, M.G. J. Biol. Chem. (2001) [Pubmed]
  9. Cyclopentenone prostaglandins as potential inducers of intracellular oxidative stress. Kondo, M., Oya-Ito, T., Kumagai, T., Osawa, T., Uchida, K. J. Biol. Chem. (2001) [Pubmed]
  10. Inhibition of herpesvirus-induced HIV-1 replication by cyclopentenone prostaglandins: role of IkappaB kinase (IKK). Amici, C., Belardo, G., Rozera, C., Bernasconi, D., Santoro, M.G. AIDS (2004) [Pubmed]
  11. Cyclopentenone prostaglandins: new insights on biological activities and cellular targets. Straus, D.S., Glass, C.K. Medicinal research reviews. (2001) [Pubmed]
  12. The cyclopentenone prostaglandin PGA2 costimulates the maturation of human dendritic cells. Thurnher, M., Putz, T., Gander, H., Rahm, A., Bartsch, G., Ramoner, R. Exp. Hematol. (2005) [Pubmed]
  13. Cyclopentenone prostaglandins suppress activation of microglia: down-regulation of inducible nitric-oxide synthase by 15-deoxy-Delta12,14-prostaglandin J2. Petrova, T.V., Akama, K.T., Van Eldik, L.J. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  14. Potentiation of protein kinase C zeta activity by 15-deoxy-delta(12,14)-prostaglandin J(2) induces an imbalance between mitogen-activated protein kinases and NF-kappa B that promotes apoptosis in macrophages. Castrillo, A., Través, P.G., Martín-Sanz, P., Parkinson, S., Parker, P.J., Boscá, L. Mol. Cell. Biol. (2003) [Pubmed]
  15. 15-Deoxy-delta 12,14-prostaglandin J2 induces apoptosis in human malignant B cells: an effect associated with inhibition of NF-kappa B activity and down-regulation of antiapoptotic proteins. Piva, R., Gianferretti, P., Ciucci, A., Taulli, R., Belardo, G., Santoro, M.G. Blood (2005) [Pubmed]
  16. Jasmonates and related oxylipins in plant responses to pathogenesis and herbivory. Farmer, E.E., Alméras, E., Krishnamurthy, V. Curr. Opin. Plant Biol. (2003) [Pubmed]
  17. Potent prostaglandin A1 analogs that suppress tumor cell growth through induction of p21 and reduction of cyclin E. Tanikawa, M., Yamada, K., Tominaga, K., Morisaki, H., Kaneko, Y., Ikeda, K., Suzuki, M., Kiho, T., Tomokiyo, K., Furuta, K., Noyori, R., Nakanishi, M. J. Biol. Chem. (1998) [Pubmed]
  18. Cyclopentenone prostaglandins induce lymphocyte apoptosis by activating the mitochondrial apoptosis pathway independent of external death receptor signaling. Nencioni, A., Lauber, K., Grünebach, F., Van Parijs, L., Denzlinger, C., Wesselborg, S., Brossart, P. J. Immunol. (2003) [Pubmed]
  19. 15-Deoxy-{Delta}12,14-Prostaglandin J2 Negatively Regulates rankl Gene Expression in Activated T Lymphocytes: Role of NF-{kappa}B and Early Growth Response Transcription Factors. Fionda, C., Nappi, F., Piccoli, M., Frati, L., Santoni, A., Cippitelli, M. J. Immunol. (2007) [Pubmed]
  20. Cytoskeleton/endoplasmic reticulum collapse induced by prostaglandin J2 parallels centrosomal deposition of ubiquitinated protein aggregates. Ogburn, K.D., Figueiredo-Pereira, M.E. J. Biol. Chem. (2006) [Pubmed]
  21. The Peroxisome Proliferator-Activated Receptor {gamma} (PPAR{gamma}) Ligands 15-Deoxy-{Delta}12,14-Prostaglandin J2 and Ciglitazone Induce Human B Lymphocyte and B Cell Lymphoma Apoptosis by PPAR{gamma}-Independent Mechanisms. Ray, D.M., Akbiyik, F., Phipps, R.P. J. Immunol. (2006) [Pubmed]
  22. 15-deoxy-Delta12,14-prostaglandin J2 inhibits glucocorticoid binding and signaling in macrophages through a peroxisome proliferator-activated receptor gamma-independent process. Cheron, A., Peltier, J., Perez, J., Bellocq, A., Fouqueray, B., Baud, L. J. Immunol. (2004) [Pubmed]
  23. Preferential binding of growth inhibitory prostaglandins by the target protein of a carcinogen. Khan, S.H., Sorof, S. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  24. The contribution of NF-kappa B activity to spontaneous proliferation and resistance to apoptosis in human T-cell leukemia virus type 1 Tax-induced tumors. Portis, T., Harding, J.C., Ratner, L. Blood (2001) [Pubmed]
  25. Cyclopentenone eicosanoids as mediators of neurodegeneration: a pathogenic mechanism of oxidative stress-mediated and cyclooxygenase-mediated neurotoxicity. Musiek, E.S., Milne, G.L., McLaughlin, B., Morrow, J.D. Brain Pathol. (2005) [Pubmed]
  26. 2-Cyclopenten-1-one, a new inducer of heat shock protein 70 with antiviral activity. Rossi, A., Elia, G., Santoro, M.G. J. Biol. Chem. (1996) [Pubmed]
  27. Cyclopentenone isoprostanes inhibit the inflammatory response in macrophages. Musiek, E.S., Gao, L., Milne, G.L., Han, W., Everhart, M.B., Wang, D., Backlund, M.G., DuBois, R.N., Zanoni, G., Vidari, G., Blackwell, T.S., Morrow, J.D. J. Biol. Chem. (2005) [Pubmed]
  28. Inhibition of activator protein 1 activation, vascular endothelial growth factor, and cyclooxygenase-2 expression by 15-deoxy-Delta12,14-prostaglandin J2 in colon carcinoma cells: evidence for a redox-sensitive peroxisome proliferator-activated receptor-gamma-independent mechanism. Grau, R., Iñiguez, M.A., Fresno, M. Cancer Res. (2004) [Pubmed]
  29. The cyclopentenone-type prostaglandin 15-deoxy-delta 12,14-prostaglandin J2 inhibits CD95 ligand gene expression in T lymphocytes: interference with promoter activation via peroxisome proliferator-activated receptor-gamma-independent mechanisms. Cippitelli, M., Fionda, C., Di Bona, D., Lupo, A., Piccoli, M., Frati, L., Santoni, A. J. Immunol. (2003) [Pubmed]
  30. Multidrug resistance protein (MRP) 1 and MRP3 attenuate cytotoxic and transactivating effects of the cyclopentenone prostaglandin, 15-deoxy-Delta(12,14)prostaglandin J2 in MCF7 breast cancer cells. Paumi, C.M., Wright, M., Townsend, A.J., Morrow, C.S. Biochemistry (2003) [Pubmed]
  31. Abrogation of IL-6-mediated JAK signalling by the cyclopentenone prostaglandin 15d-PGJ(2) in oral squamous carcinoma cells. Siavash, H., Nikitakis, N.G., Sauk, J.J. Br. J. Cancer (2004) [Pubmed]
  32. Inhibition of interleukin-6 signaling and Stat3 activation by a new class of bioactive cyclopentenone derivatives. Weidler, M., Rether, J., Anke, T., Erkel, G. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  33. 2-Cyclopenten-1-one and prostaglandin J2 reduce restenosis after balloon angioplasty in rats: role of NF-kappaB. Ianaro, A., Maffia, P., Cuzzocrea, S., Mazzon, E., Santoro, M.G., Di Rosa, M., Ialenti, A. FEBS Lett. (2003) [Pubmed]
  34. Analysis of fungal cyclopentenone derivatives from Hygrophorus spp. by liquid chromatography/electrospray-tandem mass spectrometry. Lübken, T., Arnold, N., Wessjohann, L., Böttcher, C., Schmidt, J. Journal of mass spectrometry : JMS. (2006) [Pubmed]
  35. Regulation of heme oxygenase expression by cyclopentenone prostaglandins. Zhuang, H., Pin, S., Li, X., Doré, S. Exp. Biol. Med. (Maywood) (2003) [Pubmed]
WikiGenes - Universities