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Chemical Compound Review

AG-G-15315     7-[(1R,5S)-5-[(3S)-3- hydroxyoct-1-enyl]-4...

Synonyms: SureCN5700584, KBioGR_000218, KBioSS_000218, CBiol_001991, CTK2F6683, ...
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Disease relevance of prostaglandin J2


High impact information on prostaglandin J2


Chemical compound and disease context of prostaglandin J2


Biological context of prostaglandin J2


Anatomical context of prostaglandin J2


Associations of prostaglandin J2 with other chemical compounds


Gene context of prostaglandin J2


Analytical, diagnostic and therapeutic context of prostaglandin J2


  1. Antitumor activity of delta 7-prostaglandin A1 and delta 12-prostaglandin J2 in vitro and in vivo. Kato, T., Fukushima, M., Kurozumi, S., Noyori, R. Cancer Res. (1986) [Pubmed]
  2. Prostaglandin J2 alters pro-survival and pro-death gene expression patterns and 26 S proteasome assembly in human neuroblastoma cells. Wang, Z., Aris, V.M., Ogburn, K.D., Soteropoulos, P., Figueiredo-Pereira, M.E. J. Biol. Chem. (2006) [Pubmed]
  3. Role of 15-deoxy delta(12,14) prostaglandin J2 and Nrf2 pathways in protection against acute lung injury. Mochizuki, M., Ishii, Y., Itoh, K., Iizuka, T., Morishima, Y., Kimura, T., Kiwamoto, T., Matsuno, Y., Hegab, A.E., Nomura, A., Sakamoto, T., Uchida, K., Yamamoto, M., Sekizawa, K. Am. J. Respir. Crit. Care Med. (2005) [Pubmed]
  4. 15-deoxy-Delta12,14 prostaglandin J2 up-regulates Kruppel-like factor 4 expression independently of peroxisome proliferator-activated receptor gamma by activating the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signal transduction pathway in HT-29 colon cancer cells. Chen, Z.Y., Tseng, C.C. Mol. Pharmacol. (2005) [Pubmed]
  5. Prostaglandin J2 metabolites inhibit aromatase activity by redox-sensitive mechanisms: potential implications for breast cancer therapy. Winnett, G., van Hagen, D., Schrey, M. Int. J. Cancer (2003) [Pubmed]
  6. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. Kliewer, S.A., Lenhard, J.M., Willson, T.M., Patel, I., Morris, D.C., Lehmann, J.M. Cell (1995) [Pubmed]
  7. Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12/15-lipoxygenase. Huang, J.T., Welch, J.S., Ricote, M., Binder, C.J., Willson, T.M., Kelly, C., Witztum, J.L., Funk, C.D., Conrad, D., Glass, C.K. Nature (1999) [Pubmed]
  8. Differentiation of human neuroblastoma by phenylacetate is mediated by peroxisome proliferator-activated receptor gamma. Han, S., Wada, R.K., Sidell, N. Cancer Res. (2001) [Pubmed]
  9. Cytoskeleton/endoplasmic reticulum collapse induced by prostaglandin J2 parallels centrosomal deposition of ubiquitinated protein aggregates. Ogburn, K.D., Figueiredo-Pereira, M.E. J. Biol. Chem. (2006) [Pubmed]
  10. Synergistic effect of peroxisome proliferator activated receptor-gamma and liver X receptor-alpha in the regulation of inflammation in macrophages. Piraino, G., Cook, J.A., O'Connor, M., Hake, P.W., Burroughs, T.J., Teti, D., Zingarelli, B. Shock (2006) [Pubmed]
  11. 15-deoxy prostaglandin J2 enhances allyl alcohol-induced toxicity in rat hepatocytes. Maddox, J.F., Domzalski, A.C., Roth, R.A., Ganey, P.E. Toxicol. Sci. (2004) [Pubmed]
  12. Inhibition of sequestosome 1/p62 up-regulation prevents aggregation of ubiquitinated proteins induced by prostaglandin J2 without reducing its neurotoxicity. Wang, Z., Figueiredo-Pereira, M.E. Mol. Cell. Neurosci. (2005) [Pubmed]
  13. Selective cyclo-oxygenase-2 inhibitors impair adipocyte differentiation through inhibition of the clonal expansion phase. Fajas, L., Miard, S., Briggs, M.R., Auwerx, J. J. Lipid Res. (2003) [Pubmed]
  14. 15d-prostaglandin J2 reduces multiple organ failure caused by wall-fragment of Gram-positive and Gram-negative bacteria. Dugo, L., Collin, M., Cuzzocrea, S., Thiemermann, C. Eur. J. Pharmacol. (2004) [Pubmed]
  15. Inhibition of mesangial cell nitric oxide in MRL/lpr mice by prostaglandin J2 and proliferator activation receptor-gamma agonists. Reilly, C.M., Oates, J.C., Cook, J.A., Morrow, J.D., Halushka, P.V., Gilkeson, G.S. J. Immunol. (2000) [Pubmed]
  16. Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression. Schoonjans, K., Staels, B., Auwerx, J. J. Lipid Res. (1996) [Pubmed]
  17. Upregulation of interleukin-8 expression by prostaglandin D2 metabolite 15-deoxy-delta12, 14 prostaglandin J2 (15d-PGJ2) in human THP-1 macrophages. Fu, Y., Luo, N., Lopes-Virella, M.F. Atherosclerosis (2002) [Pubmed]
  18. The cyclopentone prostaglandin 15-deoxy-Delta(12,14) prostaglandin J2 represses nitric oxide, TNF-alpha, and IL-12 production by microglial cells. Drew, P.D., Chavis, J.A. J. Neuroimmunol. (2001) [Pubmed]
  19. Nuclear receptors and autoimmune disease: the potential of PPAR agonists to treat multiple sclerosis. Racke, M.K., Gocke, A.R., Muir, M., Diab, A., Drew, P.D., Lovett-Racke, A.E. J. Nutr. (2006) [Pubmed]
  20. Peroxisome proliferator-activated receptors, orphans with ligands and functions. Schoonjans, K., Martin, G., Staels, B., Auwerx, J. Curr. Opin. Lipidol. (1997) [Pubmed]
  21. Keratinocyte differentiation is stimulated by activators of the nuclear hormone receptor PPARalpha. Hanley, K., Jiang, Y., He, S.S., Friedman, M., Elias, P.M., Bikle, D.D., Williams, M.L., Feingold, K.R. J. Invest. Dermatol. (1998) [Pubmed]
  22. 2-Cyclopenten-1-one and prostaglandin J2 reduce restenosis after balloon angioplasty in rats: role of NF-kappaB. Ianaro, A., Maffia, P., Cuzzocrea, S., Mazzon, E., Santoro, M.G., Di Rosa, M., Ialenti, A. FEBS Lett. (2003) [Pubmed]
  23. Peroxisome proliferator-activated receptor-gamma agonists inhibit experimental allergic encephalomyelitis by blocking IL-12 production, IL-12 signaling and Th1 differentiation. Natarajan, C., Bright, J.J. Genes Immun. (2002) [Pubmed]
  24. Stereoselective conjugation of prostaglandin A2 and prostaglandin J2 with glutathione, catalyzed by the human glutathione S-transferases A1-1, A2-2, M1a-1a, and P1-1. Bogaards, J.J., Venekamp, J.C., van Bladeren, P.J. Chem. Res. Toxicol. (1997) [Pubmed]
  25. Neurotoxic prostaglandin J2 enhances cyclooxygenase-2 expression in neuronal cells through the p38MAPK pathway: a death wish? Li, Z., Jansen, M., Ogburn, K., Salvatierra, L., Hunter, L., Mathew, S., Figueiredo-Pereira, M.E. J. Neurosci. Res. (2004) [Pubmed]
  26. An Arabidopsis gene induced by wounding functionally homologous to flavoprotein oxidoreductases. Costa, C.L., Arruda, P., Benedetti, C.E. Plant Mol. Biol. (2000) [Pubmed]
  27. Opposite effects of prostaglandin-J2 on VEGF in normoxia and hypoxia: role of HIF-1. Józkowicz, A., Nigisch, A., Wegrzyn, J., Weigel, G., Huk, I., Dulak, J. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  28. The peroxisome proliferator activated receptors (PPARS) and their effects on lipid metabolism and adipocyte differentiation. Schoonjans, K., Staels, B., Auwerx, J. Biochim. Biophys. Acta (1996) [Pubmed]
  29. Differential regulation of chemokine gene expression by 15-deoxy-delta 12,14 prostaglandin J2. Zhang, X., Wang, J.M., Gong, W.H., Mukaida, N., Young, H.A. J. Immunol. (2001) [Pubmed]
  30. Estrogen-induced production of a peroxisome proliferator-activated receptor (PPAR) ligand in a PPARgamma-expressing tissue. Ma, H., Sprecher, H.W., Kolattukudy, P.E. J. Biol. Chem. (1998) [Pubmed]
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