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Gene Review

LOC543527  -  homeobox-leucine zipper protein ATHB-13

Solanum lycopersicum

Synonyms: JA1, LEJA1
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Disease relevance of LEJA1


High impact information on LEJA1

  • Jasmonic acid (JA) is a lipid-derived signal that regulates plant defense responses to biotic stress [4].
  • Map-based cloning studies demonstrated that this phenotype results from loss of function of an acyl-CoA oxidase (ACX1A) that catalyzes the first step in the peroxisomal beta-oxidation stage of JA biosynthesis [4].
  • Our results demonstrate that the JA signaling pathway strongly influences the midgut protein content of phytophagous insects and support the hypothesis that catabolism of amino acids in the insect digestive tract by host enzymes plays a role in plant protection against herbivores [5].
  • Numerous complex changes induced by pathogen infection, including the accumulation of COR, salicylic acid, jasmonic acid, indole-3-acetic acid, and abscisic acid illustrate the potential and simplicity of this approach in quantifying signaling crosstalk interactions that occur at the level of synthesis and accumulation [6].
  • The chemical analysis of salicylic acid, jasmonic acid, indole-3-acetic acid, and abscisic acid is typically achieved by using separate and complex methodologies [6].

Biological context of LEJA1

  • This response was mediated by the bacterial phytotoxin coronatine, which exerts its virulence effects by co-opting the host JA signaling pathway [7].
  • Wound- and JA-induced expression of LeARG2 was not observed in the tomato jasmonic acid-insensitive1 mutant, indicating that this response is strictly dependent on an intact JA signal transduction pathway [7].
  • Jasmonic acid-dependent and -independent signaling pathways control wound-induced gene activation in Arabidopsis thaliana [8].
  • However, the hatching-rate of eggs on def-1 was significantly higher, suggesting that JA-dependent direct defenses enhanced egg mortality or increased the time needed for embryonic development [1].
  • Treatment of def-1 plants with methyl-JA restored resistance to spider mite feeding and reduced the fecundity of female mites [9].

Anatomical context of LEJA1

  • The OPR3 protein and activity were consistently found in peroxisomes where they co-localize with the enzymes of beta-oxidation which catalyze the final steps in the formation of jasmonic acid [10].
  • Porcine pancreas trypsin and Spodoptera litura gut proteinases were inhibited in the presence of leaf proteins treated with JA, and TRIA partially reverses this effect [3].

Associations of LEJA1 with chemical compounds


Regulatory relationships of LEJA1

  • In leaves, LeARG2 expression and arginase activity were induced in response to wounding and treatment with jasmonic acid (JA), a potent signal for plant defense responses [7].

Other interactions of LEJA1


Analytical, diagnostic and therapeutic context of LEJA1

  • Third, microarray analysis using Arabidopsis whole-genome chip demonstrates that the gene expression profile of bestatin-treated plants is similar to that of JA-treated plants [11].
  • In suspension-cultured rice ( Oryza sativaL.) cells, jasmonic acid (JA) functions as a signal transducer in elicitor N-acetylchitoheptaose-induced phytoalexin production [17].
  • After treatment of tomato leaves with (10-(2)H)-(-)-12-oxophytoenoic acid, (4-(2)H)-(-)-JA and its methyl ester were formed and could be quantified separately from the endogenously nonlabeled JA pool by GC-MS analysis via isotopic discrimination [18].


  1. Jasmonic acid is a key regulator of spider mite-induced volatile terpenoid and methyl salicylate emission in tomato. Ament, K., Kant, M.R., Sabelis, M.W., Haring, M.A., Schuurink, R.C. Plant Physiol. (2004) [Pubmed]
  2. Multiple hormones act sequentially to mediate a susceptible tomato pathogen defense response. O'Donnell, P.J., Schmelz, E., Block, A., Miersch, O., Wasternack, C., Jones, J.B., Klee, H.J. Plant Physiol. (2003) [Pubmed]
  3. Triacontanol negatively modulates the jasmonic acid-stimulated proteinase inhibitors in tomato (Lycopersicon esculentum). Ramanarayan, K., Swamy, G.S. J. Plant Physiol. (2004) [Pubmed]
  4. Role of beta-oxidation in jasmonate biosynthesis and systemic wound signaling in tomato. Li, C., Schilmiller, A.L., Liu, G., Lee, G.I., Jayanty, S., Sageman, C., Vrebalov, J., Giovannoni, J.J., Yagi, K., Kobayashi, Y., Howe, G.A. Plant Cell (2005) [Pubmed]
  5. Jasmonate-inducible plant enzymes degrade essential amino acids in the herbivore midgut. Chen, H., Wilkerson, C.G., Kuchar, J.A., Phinney, B.S., Howe, G.A. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  6. Simultaneous analysis of phytohormones, phytotoxins, and volatile organic compounds in plants. Schmelz, E.A., Engelberth, J., Alborn, H.T., O'Donnell, P., Sammons, M., Toshima, H., Tumlinson, J.H. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  7. Regulation of plant arginase by wounding, jasmonate, and the phytotoxin coronatine. Chen, H., McCaig, B.C., Melotto, M., He, S.Y., Howe, G.A. J. Biol. Chem. (2004) [Pubmed]
  8. Jasmonic acid-dependent and -independent signaling pathways control wound-induced gene activation in Arabidopsis thaliana. Titarenko, E., Rojo, E., León, J., Sánchez-Serrano, J.J. Plant Physiol. (1997) [Pubmed]
  9. Resistance of cultivated tomato to cell content-feeding herbivores is regulated by the octadecanoid-signaling pathway. Li, C., Williams, M.M., Loh, Y.T., Lee, G.I., Howe, G.A. Plant Physiol. (2002) [Pubmed]
  10. Characterization and cDNA-microarray expression analysis of 12-oxophytodienoate reductases reveals differential roles for octadecanoid biosynthesis in the local versus the systemic wound response. Strassner, J., Schaller, F., Frick, U.B., Howe, G.A., Weiler, E.W., Amrhein, N., Macheroux, P., Schaller, A. Plant J. (2002) [Pubmed]
  11. Bestatin, an inhibitor of aminopeptidases, provides a chemical genetics approach to dissect jasmonate signaling in Arabidopsis. Zheng, W., Zhai, Q., Sun, J., Li, C.B., Zhang, L., Li, H., Zhang, X., Li, S., Xu, Y., Jiang, H., Wu, X., Li, C. Plant Physiol. (2006) [Pubmed]
  12. Nitric oxide negatively modulates wound signaling in tomato plants. Orozco-Cárdenas, M.L., Ryan, C.A. Plant Physiol. (2002) [Pubmed]
  13. Cytochrome P450-dependent metabolism of oxylipins in tomato. Cloning and expression of allene oxide synthase and fatty acid hydroperoxide lyase. Howe, G.A., Lee, G.I., Itoh, A., Li, L., DeRocher, A.E. Plant Physiol. (2000) [Pubmed]
  14. The Pseudomonas syringae avrRpt2 gene contributes to virulence on tomato. Lim, M.T., Kunkel, B.N. Mol. Plant Microbe Interact. (2005) [Pubmed]
  15. Expression of allene oxide synthase determines defense gene activation in tomato. Sivasankar, S., Sheldrick, B., Rothstein, S.J. Plant Physiol. (2000) [Pubmed]
  16. Salt stress activation of wound-related genes in tomato plants. Dombrowski, J.E. Plant Physiol. (2003) [Pubmed]
  17. Cloning and characterization of a jasmonic acid-responsive gene encoding 12-oxophytodienoic acid reductase in suspension-cultured rice cells. Sobajima, H., Takeda, M., Sugimori, M., Kobashi, N., Kiribuchi, K., Cho, E.M., Akimoto, C., Yamaguchi, T., Minami, E., Shibuya, N., Schaller, F., Weiler, E.W., Yoshihara, T., Nishida, H., Nojiri, H., Omori, T., Nishiyama, M., Yamane, H. Planta (2003) [Pubmed]
  18. Octadecanoid and jasmonate signaling in tomato (Lycopersicon esculentum Mill.) leaves: endogenous jasmonates do not induce jasmonate biosynthesis. Miersch, O., Wasternack, C. Biol. Chem. (2000) [Pubmed]
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