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Nfkb1  -  nuclear factor of kappa light polypeptide...

Rattus norvegicus

Synonyms: DNA-binding factor KBF1, EBP-1, NF-kB, Nuclear factor NF-kappa-B p105 subunit, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
 
 
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High impact information on Nfkb1

  • Nuclear Akt associates with PKC-phosphorylated Ebp1, preventing DNA fragmentation by inhibition of caspase-activated DNase [1].
  • Thus, nuclear Akt might contribute to suppressing apoptosis through interaction with Ebp1 [1].
  • Ebp1 (S360A), which cannot be phosphorylated by PKC, barely binds Akt or inhibits DNA fragmentation, whereas Ebp1 S360D, which mimics phosphorylation, strongly binds Akt and suppresses apoptosis [1].
  • Depletion of Ebp1 from nuclear extracts or knockdown of Ebp1 in PC12 cells abolishes the protective effects of nerve growth factor, whereas overexpression of Ebp1 prevents apoptosis [1].
  • Thus, Ebp1 might regulate cell survival and differentiation through two distinctive p48 and p42 isoforms [2].
 

Biological context of Nfkb1

 

Anatomical context of Nfkb1

  • Here, we show that Ebp1 possesses two different isoforms, p48 and p42, which differentially mediate PC12 cell survival and differentiation [2].
 

Other interactions of Nfkb1

References

  1. Nuclear Akt associates with PKC-phosphorylated Ebp1, preventing DNA fragmentation by inhibition of caspase-activated DNase. Ahn, J.Y., Liu, X., Liu, Z., Pereira, L., Cheng, D., Peng, J., Wade, P.A., Hamburger, A.W., Ye, K. EMBO J. (2006) [Pubmed]
  2. Ebp1 isoforms distinctively regulate cell survival and differentiation. Liu, Z., Ahn, J.Y., Liu, X., Ye, K. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  3. Mucosal expression of genes encoding possible upstream regulators of Na+ transport during pneumococcal otitis media. Li, H.S., Doyle, W.J., Swarts, J.D., Lo, C.Y., Hebda, P.A. Acta Otolaryngol. (2003) [Pubmed]
 
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