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Gene Review

Atp1a1  -  ATPase, Na+/K+ transporting, alpha 1...

Rattus norvegicus

Synonyms: Na(+)/K(+) ATPase alpha-1 subunit, Sodium pump subunit alpha-1, Sodium/potassium-transporting ATPase subunit alpha-1
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Disease relevance of Atp1a1


High impact information on Atp1a1


Biological context of Atp1a1


Anatomical context of Atp1a1


Associations of Atp1a1 with chemical compounds

  • In conclusion, abnormal cholesterol metabolism but not the Atp1a1 gene locus might represent an important factor for both high BP and altered Na(+)-K(+) pump function in salt-hypertensive Dahl rats [12].
  • Sodium pump inhibition by ouabain (10(-4) M) dramatically enhanced the carbachol depolarizations [19].

Other interactions of Atp1a1


  1. Neither the New Zealand genetically hypertensive strain nor Dahl salt-sensitive strain has an A1079T transversion in the alpha1 isoform of the Na(+),K(+)-ATPase gene. Barnard, R., Kelly, G., Manzetti, S.O., Harris, E.L. Hypertension (2001) [Pubmed]
  2. Sodium pump activity in arteries of rats with Goldblatt hypertension. Overbeck, H.W., Grissette, D.E. Hypertension (1982) [Pubmed]
  3. Sodium pump failure in hypoxia and reoxygenation. Grinwald, P.M. J. Mol. Cell. Cardiol. (1992) [Pubmed]
  4. Sodium-pump injury and arrhythmogenic transient depolarizations in catecholamine-induced cardiac hypertrophy. Mészáros, J. Eur. J. Pharmacol. (1992) [Pubmed]
  5. Sodium pump in skeletal muscle: central nervous system-induced suppression by alpha-adrenoreceptors. Akaike, N. Science (1981) [Pubmed]
  6. Sodium pump activity and calcium relaxation in vascular smooth muscle of deoxycorticosterone acetate-salt rats. Soltis, E.E., Field, F.P. Hypertension (1986) [Pubmed]
  7. Sodium pump activity in arteries of Dahl salt-sensitive rats. Overbeck, H.W., Ku, D.D., Rapp, J.P. Hypertension (1981) [Pubmed]
  8. Sodium pump evokes high density pump currents in rat midbrain dopamine neurons. Shen, K.Z., Johnson, S.W. J. Physiol. (Lond.) (1998) [Pubmed]
  9. Effects of extracellular calcium and potassium on the sodium pump of rat adrenal glomerulosa cells. Yingst, D.R., Davis, J., Schiebinger, R. Am. J. Physiol., Cell Physiol. (2001) [Pubmed]
  10. Synergism of the ATF/CRE site and GC box in the housekeeping Na,K-ATPase alpha1 subunit gene is essential for constitutive expression. Kobayashi, M., Kawakami, K. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  11. Replacement of (alpha)1-Na-K-ATPase of Dahl rats by Milan rats lowers blood pressure but does not affect its activity. Orlov, S.N., Dutil, J., Hamet, P., Deng, A.Y. Physiol. Genomics (2001) [Pubmed]
  12. Altered Na+-K+ pump activity and plasma lipids in salt-hypertensive Dahl rats: relationship to Atp1a1 gene. Zicha, J., Negrin, C.D., Dobesová, Z., Carr, F., Vokurková, M., McBride, M.W., Kunes, J., Dominiczak, A.F. Physiol. Genomics (2001) [Pubmed]
  13. Small intestinal Na+,K+-adenosine triphosphatase activity and gene expression in experimental diabetes mellitus. Wild, G.E., Thompson, J.A., Searles, L., Turner, R., Hasan, J., Thomson, A.B. Dig. Dis. Sci. (1999) [Pubmed]
  14. Sodium pump activity, not glial spatial buffering, clears potassium after epileptiform activity induced in the dentate gyrus. Xiong, Z.Q., Stringer, J.L. J. Neurophysiol. (2000) [Pubmed]
  15. Sodium pump activity and contraction of renal artery from spontaneously hypertensive rats. Sakai, Y., Inazu, M. Eur. J. Pharmacol. (1991) [Pubmed]
  16. Sodium-potassium-adenosine triphosphatase in nephron segments of spontaneously hypertensive rats. Garg, L.C., Narang, N. J. Lab. Clin. Med. (1985) [Pubmed]
  17. Sodium pump activity and norepinephrine responsiveness of femoral arterial smooth muscle from DOCA-salt rats. Soltis, E.E., Field, F.P. Pharmacology (1987) [Pubmed]
  18. On the ouabain-sensitive potassium activated p-nitrophenyl phosphatase activity of vascular muscle plasma membranes. Kwan, C.Y., Grover, A.K., Daniel, E.E. Archives internationales de pharmacodynamie et de thérapie. (1984) [Pubmed]
  19. Influence of chloride and sodium pump activity on carbachol- and acetylaholine-induced depolarizations in denervated rat diphragm. Mooij, J.J. Eur. J. Pharmacol. (1976) [Pubmed]
  20. Mucosal expression of genes encoding possible upstream regulators of Na+ transport during pneumococcal otitis media. Li, H.S., Doyle, W.J., Swarts, J.D., Lo, C.Y., Hebda, P.A. Acta Otolaryngol. (2003) [Pubmed]
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