The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Dffb  -  DNA fragmentation factor, 40kDa, beta...

Rattus norvegicus

Synonyms: CAD, Cad, Caspase-activated DNase, Caspase-activated deoxyribonuclease, DFF-40, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Dffb


Psychiatry related information on Dffb


High impact information on Dffb


Biological context of Dffb


Anatomical context of Dffb


Associations of Dffb with chemical compounds


Other interactions of Dffb

  • Either caspase-activated DNase is activated by another enzyme, or a caspase-independent DNase is responsible for the DNA cleavage [16].
  • DFF40 is typically bound to the 45-kDa subunit of DFF (DFF45), and activation of DFF40 may occur as a result of caspase-3-mediated cleavage of DFF45 into 30- and 11-kDa fragments [4].

Analytical, diagnostic and therapeutic context of Dffb

  • In hamster brain, CAD immunofluorescence was also found in cells closely related to astrocytes, i.e., the Bergmann glia in cerebellum and the tanycytes surrounding the third ventricle [15].
  • At 24, 48, or 72 h after SE termination, protein levels of CAD and ICAD were measured by Western blotting (after sodium dodecyl sulfate-polyacrylamide gel electrophoresis) using specific antibodies [17].
  • We conclude that the use of cell cultures may prove valuable in studying the reversibility of CAD-induced phospholipidosis [18].


  1. Caspase-activated DNase/DNA fragmentation factor 40 mediates apoptotic DNA fragmentation in transient cerebral ischemia and in neuronal cultures. Cao, G., Pei, W., Lan, J., Stetler, R.A., Luo, Y., Nagayama, T., Graham, S.H., Yin, X.M., Simon, R.P., Chen, J. J. Neurosci. (2001) [Pubmed]
  2. Simian virus 40 large tumor antigen alone or two cooperating oncogenes convert REF52 cells to a state permissive for gene amplification. Perry, M.E., Commane, M., Stark, G.R. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  3. Induction of caspase-activated deoxyribonuclease activity after focal cerebral ischemia and reperfusion. Luo, Y., Cao, G., Pei, W., O'Horo, C., Graham, S.H., Chen, J. J. Cereb. Blood Flow Metab. (2002) [Pubmed]
  4. Regional and temporal alterations in DNA fragmentation factor (DFF)-like proteins following experimental brain trauma in the rat. Zhang, C., Raghupathi, R., Saatman, K.E., LaPlaca, M.C., McIntosh, T.K. J. Neurochem. (1999) [Pubmed]
  5. Effects of intracerebroventricular administration of aliphatic diamines on ingestive behavior in the rat. Kohno, H., Sakurada, T., Kisara, K. Jpn. J. Pharmacol. (1981) [Pubmed]
  6. Regulation of carbamoyl phosphate synthetase by MAP kinase. Graves, L.M., Guy, H.I., Kozlowski, P., Huang, M., Lazarowski, E., Pope, R.M., Collins, M.A., Dahlstrand, E.N., Earp, H.S., Evans, D.R. Nature (2000) [Pubmed]
  7. Nucleophosmin/B23, a nuclear PI(3,4,5)P(3) receptor, mediates the antiapoptotic actions of NGF by inhibiting CAD. Ahn, J.Y., Liu, X., Cheng, D., Peng, J., Chan, P.K., Wade, P.A., Ye, K. Mol. Cell (2005) [Pubmed]
  8. Prostaglandin F2alpha-mediated activation of apoptotic signaling cascades in the corpus luteum during apoptosis: involvement of caspase-activated DNase. Yadav, V.K., Lakshmi, G., Medhamurthy, R. J. Biol. Chem. (2005) [Pubmed]
  9. Increased incidence of CAD gene amplification in tumorigenic rat lines as an indicator of genomic instability of neoplastic cells. Otto, E., McCord, S., Tlsty, T.D. J. Biol. Chem. (1989) [Pubmed]
  10. 2-Chloroadenosine decreases long-term potentiation in the hippocampal CA1 area of the rat. de Mendonça, A., Ribeiro, J.A. Neurosci. Lett. (1990) [Pubmed]
  11. A novel inhibitor that protects apoptotic DNA fragmentation catalyzed by DNase gamma. Sunaga, S., Kobayashi, T., Yoshimori, A., Shiokawa, D., Tanuma, S. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  12. Caspase-3 and caspase-activated deoxyribonuclease are associated with testicular germ cell apoptosis resulting from reduced intratesticular testosterone. Kim, J.M., Ghosh, S.R., Weil, A.C., Zirkin, B.R. Endocrinology (2001) [Pubmed]
  13. Identification of caspase-3 and caspase-activated deoxyribonuclease in rat blastocysts and their implication in the induction of chromatin degradation (but not nuclear fragmentation) by high glucose. Hinck, L., Van Der Smissen, P., Heusterpreute, M., Donnay, I., De Hertogh, R., Pampfer, S. Biol. Reprod. (2001) [Pubmed]
  14. Quercetin protects the hydrogen peroxide-induced apoptosis via inhibition of mitochondrial dysfunction in H9c2 cardiomyoblast cells. Park, C., So, H.S., Shin, C.H., Baek, S.H., Moon, B.S., Shin, S.H., Lee, H.S., Lee, D.W., Park, R. Biochem. Pharmacol. (2003) [Pubmed]
  15. Localization of the multifunctional protein CAD in astrocytes of rodent brain. Cammer, W., Downing, M. J. Histochem. Cytochem. (1991) [Pubmed]
  16. Caspase-3 is not activated in seizure-induced neuronal necrosis with internucleosomal DNA cleavage. Fujikawa, D.G., Ke, X., Trinidad, R.B., Shinmei, S.S., Wu, A. J. Neurochem. (2002) [Pubmed]
  17. Status epilepticus leads to the degradation of the endogenous inhibitor of caspase-activated DNase in rats. Kondratyev, A., Selby, D., Gale, K. Neurosci. Lett. (2002) [Pubmed]
  18. In vivo and in vitro reversibility of chlorphentermine-induced phospholipidosis in rat alveolar macrophages. McCloud, C.M., Beard, T.L., Kacew, S., Reasor, M.J. Exp. Mol. Pathol. (1995) [Pubmed]
WikiGenes - Universities