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Gene Review

CDC48  -  cell division control protein 48-A

Arabidopsis thaliana

Synonyms: ATCDC48, CDC48A, cell division cycle 48
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High impact information on CDC48


Biological context of CDC48

  • Fluorescent lifetime imaging microscopy (FLIM) was used to detect F??rster resonance energy transfer (FRET) between CrFP/YFP-tagged CDC48A and SERK1 [4].

Anatomical context of CDC48


Enzymatic interactions of CDC48


Other interactions of CDC48

  • Models for the role of AtCDC48 and SYP31 at the division plane will be discussed [7].
  • These results suggest that there are at least two distinct membrane fusion pathways involving Cdc48p/p97 and Sec18p/NSF that operate at the division plane to mediate plant cytokinesis [7].
  • ATPase activity in both the D1 and the D2 domains was critical for PUX1-mediated AtCDC48 hexamer disassembly [8].


  1. The higher plant Arabidopsis thaliana encodes a functional CDC48 homologue which is highly expressed in dividing and expanding cells. Feiler, H.S., Desprez, T., Santoni, V., Kronenberger, J., Caboche, M., Traas, J. EMBO J. (1995) [Pubmed]
  2. The Arabidopsis SOMATIC EMBRYOGENESIS RECEPTOR-LIKE KINASE1 protein complex includes BRASSINOSTEROID-INSENSITIVE1. Karlova, R., Boeren, S., Russinova, E., Aker, J., Vervoort, J., de Vries, S. Plant Cell (2006) [Pubmed]
  3. Plant UBX domain-containing protein 1, PUX1, regulates the oligomeric structure and activity of arabidopsis CDC48. Rancour, D.M., Park, S., Knight, S.D., Bednarek, S.Y. J. Biol. Chem. (2004) [Pubmed]
  4. The Arabidopsis thaliana AAA protein CDC48A interacts in vivo with the somatic embryogenesis receptor-like kinase 1 receptor at the plasma membrane. Aker, J., Borst, J.W., Karlova, R., de Vries, S. J. Struct. Biol. (2006) [Pubmed]
  5. The Arabidopsis SERK1 protein interacts with the AAA-ATPase AtCDC48, the 14-3-3 protein GF14lambda and the PP2C phosphatase KAPP. Rienties, I.M., Vink, J., Borst, J.W., Russinova, E., de Vries, S.C. Planta (2005) [Pubmed]
  6. In vivo hexamerization and characterization of the Arabidopsis AAA ATPase CDC48A complex using forster resonance energy transfer-fluorescence lifetime imaging microscopy and fluorescence correlation spectroscopy. Aker, J., Hesselink, R., Engel, R., Karlova, R., Borst, J.W., Visser, A.J., de Vries, S.C. Plant Physiol. (2007) [Pubmed]
  7. Characterization of AtCDC48. Evidence for multiple membrane fusion mechanisms at the plane of cell division in plants. Rancour, D.M., Dickey, C.E., Park, S., Bednarek, S.Y. Plant Physiol. (2002) [Pubmed]
  8. Protein domain-domain interactions and requirements for the negative regulation of Arabidopsis CDC48/p97 by the plant ubiquitin regulatory X (UBX) domain-containing protein, PUX1. Park, S., Rancour, D.M., Bednarek, S.Y. J. Biol. Chem. (2007) [Pubmed]
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