The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Vcp  -  valosin-containing protein

Rattus norvegicus

Synonyms: 15S Mg(2+)-ATPase p97 subunit, TER ATPase, Transitional endoplasmic reticulum ATPase, VCP, Valosin-containing protein
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Vcp

  • Excessive accumulation of misfolded proteins may inactivate p97/VCP in several neurodegenerative disorders, eventually leading to the neurodegenerations [1].
 

Psychiatry related information on Vcp

 

High impact information on Vcp

 

Biological context of Vcp

  • These results suggest that VCP functions not only as a recognition factor for abnormally folded proteins but also as a pathological effector for several neurodegenerative phenotypes [2].
  • Moreover, the expression of VCP mutants with mutations in the 2nd ATP binding domain created cytoplasmic vacuoles, followed by cell death [2].
  • Akt-mediated valosin-containing protein 97 phosphorylation regulates its association with ubiquitinated proteins [4].
  • Alanine-scanning mutagenesis of charged residues, tyrosines, and phenylalanines in extracellular CXCR4 domains implicated multiple amino acids in the N terminus (E14/E15, D20, Y21, and D22), ECL2 (D187, R188, F189, Y190, and D193), and ECL3 (D262, E268, E277, and E282) in binding, although minor differences were noted between VCP and ROD/B [5].
 

Associations of Vcp with chemical compounds

  • In addition, VCP expression and association with Akt was enhanced during SH, and this association was decreased upon phosphoinositide 3-kinase/Akt pathway blockade with LY294002 [4].
 

Other interactions of Vcp

  • The AAA ATPase p97/VCP interacts with its alternative co-factors, Ufd1-Npl4 and p47, through a common bipartite binding mechanism [6].
 

Analytical, diagnostic and therapeutic context of Vcp

References

  1. Functional ATPase activity of p97/valosin-containing protein (VCP) is required for the quality control of endoplasmic reticulum in neuronally differentiated mammalian PC12 cells. Kobayashi, T., Tanaka, K., Inoue, K., Kakizuka, A. J. Biol. Chem. (2002) [Pubmed]
  2. VCP/p97 in abnormal protein aggregates, cytoplasmic vacuoles, and cell death, phenotypes relevant to neurodegeneration. Hirabayashi, M., Inoue, K., Tanaka, K., Nakadate, K., Ohsawa, Y., Kamei, Y., Popiel, A.H., Sinohara, A., Iwamatsu, A., Kimura, Y., Uchiyama, Y., Hori, S., Kakizuka, A. Cell Death Differ. (2001) [Pubmed]
  3. Isolation and characterization of the principal ATPase associated with transitional endoplasmic reticulum of rat liver. Zhang, L., Ashendel, C.L., Becker, G.W., Morré, D.J. J. Cell Biol. (1994) [Pubmed]
  4. Akt-mediated valosin-containing protein 97 phosphorylation regulates its association with ubiquitinated proteins. Klein, J.B., Barati, M.T., Wu, R., Gozal, D., Sachleben, L.R., Kausar, H., Trent, J.O., Gozal, E., Rane, M.J. J. Biol. Chem. (2005) [Pubmed]
  5. Identification of gp120 binding sites on CXCR4 by using CD4-independent human immunodeficiency virus type 2 Env proteins. Lin, G., Baribaud, F., Romano, J., Doms, R.W., Hoxie, J.A. J. Virol. (2003) [Pubmed]
  6. The AAA ATPase p97/VCP interacts with its alternative co-factors, Ufd1-Npl4 and p47, through a common bipartite binding mechanism. Bruderer, R.M., Brasseur, C., Meyer, H.H. J. Biol. Chem. (2004) [Pubmed]
 
WikiGenes - Universities