Gene Review:
VCP - valosin containing protein
Homo sapiens
Synonyms:
15S Mg(2+)-ATPase p97 subunit, ALS14, HEL-220, HEL-S-70, IBMPFD, ...
- VCP (p97) regulates NFkappaB signaling pathway, which is important for metastasis of osteosarcoma cell line. Asai, T., Tomita, Y., Nakatsuka, S., Hoshida, Y., Myoui, A., Yoshikawa, H., Aozasa, K. Jpn. J. Cancer Res. (2002)
- Physical and functional interaction between Dorfin and Valosin-containing protein that are colocalized in ubiquitylated inclusions in neurodegenerative disorders. Ishigaki, S., Hishikawa, N., Niwa, J., Iemura, S., Natsume, T., Hori, S., Kakizuka, A., Tanaka, K., Sobue, G. J. Biol. Chem. (2004)
- Valosin-containing protein, VCP, is a ubiquitous clathrin-binding protein. Pleasure, I.T., Black, M.M., Keen, J.H. Nature (1993)
- Mutant valosin-containing protein causes a novel type of frontotemporal dementia. Schröder, R., Watts, G.D., Mehta, S.G., Evert, B.O., Broich, P., Fliessbach, K., Pauls, K., Hans, V.H., Kimonis, V., Thal, D.R. Ann. Neurol. (2005)
- Elevated expression of valosin-containing protein (p97) in hepatocellular carcinoma is correlated with increased incidence of tumor recurrence. Yamamoto, S., Tomita, Y., Nakamori, S., Hoshida, Y., Nagano, H., Dono, K., Umeshita, K., Sakon, M., Monden, M., Aozasa, K. J. Clin. Oncol. (2003)
- Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein. Watts, G.D., Wymer, J., Kovach, M.J., Mehta, S.G., Mumm, S., Darvish, D., Pestronk, A., Whyte, M.P., Kimonis, V.E. Nat. Genet. (2004)
- Tyrosine phosphorylation of VCP, the mammalian homologue of the Saccharomyces cerevisiae CDC48 protein, is unusually sensitive to stimulation by sodium vanadate and hydrogen peroxide. Schulte, R.J., Campbell, M.A., Fischer, W.H., Sefton, B.M. J. Immunol. (1994)
- Metastasis stage, adjuvant treatment, and residual tumor are prognostic factors for medulloblastoma in children: conclusions from the Children's Cancer Group 921 randomized phase III study. Zeltzer, P.M., Boyett, J.M., Finlay, J.L., Albright, A.L., Rorke, L.B., Milstein, J.M., Allen, J.C., Stevens, K.R., Stanley, P., Li, H., Wisoff, J.H., Geyer, J.R., McGuire-Cullen, P., Stehbens, J.A., Shurin, S.B., Packer, R.J. J. Clin. Oncol. (1999)
- CD4-independent use of Rhesus CCR5 by human immunodeficiency virus Type 2 implicates an electrostatic interaction between the CCR5 N terminus and the gp120 C4 domain. Lin, G., Lee, B., Haggarty, B.S., Doms, R.W., Hoxie, J.A. J. Virol. (2001)
- Primary structure of the human melanoma-associated antigen p97 (melanotransferrin) deduced from the mRNA sequence. Rose, T.M., Plowman, G.D., Teplow, D.B., Dreyer, W.J., Hellström, K.E., Brown, J.P. Proc. Natl. Acad. Sci. U.S.A. (1986)
- Biochemical properties of the high-molecular-weight glycopeptides released from the cell surface of human teratocarcinoma cells. Muramatsu, H., Muramatsu, T., Avner, P. Cancer Res. (1982)
- Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation. Ficarro, S., Chertihin, O., Westbrook, V.A., White, F., Jayes, F., Kalab, P., Marto, J.A., Shabanowitz, J., Herr, J.C., Hunt, D.F., Visconti, P.E. J. Biol. Chem. (2003)
- Chromosome localization of human genes for clathrin adaptor polypeptides AP2 beta and AP50 and the clathrin-binding protein, VCP. Druck, T., Gu, Y., Prabhala, G., Cannizzaro, L.A., Park, S.H., Huebner, K., Keen, J.H. Genomics (1995)
- Valosin-containing protein (p97) and Ki-67 expression is a useful marker in detecting malignant behavior of pancreatic endocrine neoplasms. Yamamoto, S., Tomita, Y., Nakamori, S., Hoshida, Y., Iizuka, N., Okami, J., Nagano, H., Dono, K., Umeshita, K., Sakon, M., Ishikawa, O., Ohigashi, H., Aozasa, K., Monden, M. Oncology (2004)
- Syntaxin 5 is a common component of the NSF- and p97-mediated reassembly pathways of Golgi cisternae from mitotic Golgi fragments in vitro. Rabouille, C., Kondo, H., Newman, R., Hui, N., Freemont, P., Warren, G. Cell (1998)
- Identification of the cell cycle regulator VCP (p97/CDC48) as a substrate of the band 4.1-related protein-tyrosine phosphatase PTPH1. Zhang, S.H., Liu, J., Kobayashi, R., Tonks, N.K. J. Biol. Chem. (1999)
- Yeast two-hybrid screening identifies binding partners of human Tom34 that have ATPase activity and form a complex with Tom34 in the cytosol. Yang, C.S., Weiner, H. Arch. Biochem. Biophys. (2002)
- Pathological consequences of VCP mutations on human striated muscle. Hübbers, C.U., Clemen, C.S., Kesper, K., Böddrich, A., Hofmann, A., Kämäräinen, O., Tolksdorf, K., Stumpf, M., Reichelt, J., Roth, U., Krause, S., Watts, G., Kimonis, V., Wattjes, M.P., Reimann, J., Thal, D.R., Biermann, K., Evert, B.O., Lochmüller, H., Wanker, E.E., Schoser, B.G., Noegel, A.A., Schröder, R. Brain (2007)
- Functional ATPase activity of p97/valosin-containing protein (VCP) is required for the quality control of endoplasmic reticulum in neuronally differentiated mammalian PC12 cells. Kobayashi, T., Tanaka, K., Inoue, K., Kakizuka, A. J. Biol. Chem. (2002)
- Selective inhibition of endoplasmic reticulum-associated degradation rescues DeltaF508-cystic fibrosis transmembrane regulator and suppresses interleukin-8 levels: therapeutic implications. Vij, N., Fang, S., Zeitlin, P.L. J. Biol. Chem. (2006)
- Inaugural Article: Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane. Ye, Y., Shibata, Y., Kikkert, M., van Voorden, S., Wiertz, E., Rapoport, T.A. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Ataxin-3 binds VCP/p97 and regulates retrotranslocation of ERAD substrates. Zhong, X., Pittman, R.N. Hum. Mol. Genet. (2006)
- Human Fas-associated factor 1, interacting with ubiquitinated proteins and valosin-containing protein, is involved in the ubiquitin-proteasome pathway. Song, E.J., Yim, S.H., Kim, E., Kim, N.S., Lee, K.J. Mol. Cell. Biol. (2005)
- The PUB domain functions as a p97 binding module in human peptide N-glycanase. Allen, M.D., Buchberger, A., Bycroft, M. J. Biol. Chem. (2006)
- An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis. Boeddrich, A., Gaumer, S., Haacke, A., Tzvetkov, N., Albrecht, M., Evert, B.O., Müller, E.C., Lurz, R., Breuer, P., Schugardt, N., Plassmann, S., Xu, K., Warrick, J.M., Suopanki, J., Wüllner, U., Frank, R., Hartl, U.F., Bonini, N.M., Wanker, E.E. EMBO J. (2006)
- Pre-B-cell leukemia transcription factor 1 regulates expression of valosin-containing protein, a gene involved in cancer growth. Qiu, Y., Tomita, Y., Zhang, B., Nakamichi, I., Morii, E., Aozasa, K. Am. J. Pathol. (2007)
- Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation. Oda, Y., Okada, T., Yoshida, H., Kaufman, R.J., Nagata, K., Mori, K. J. Cell Biol. (2006)
- NSF and p97/VCP: similar at first, different at last. Brunger, A.T., DeLaBarre, B. FEBS Lett. (2003)
- Valosin-containing Protein (p97) Is a Regulator of Endoplasmic Reticulum Stress and of the Degradation of N-End Rule and Ubiquitin-Fusion Degradation Pathway Substrates in Mammalian Cells. W??jcik, C., Rowicka, M., Kudlicki, A., Nowis, D., McConnell, E., Kujawa, M., Demartino, G.N. Mol. Biol. Cell (2006)
- SAV, an archaebacterial gene with extensive homology to a family of highly conserved eukaryotic ATPases. Confalonieri, F., Marsault, J., Duguet, M. J. Mol. Biol. (1994)