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Gene Review

TER94  -  CG2331 gene product from transcript CG2331-RA

Drosophila melanogaster

Synonyms: 22.26, 7.12, Apple, BcDNA.GM02885, BcDNA:GM02885, ...
 
 
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High impact information on TER94

  • A number of genes known to have proteasome-related functions, including Rad23, isopeptidase T, sequestosome, and the genes for the segregase complex TER94/VCP-Ufd1-Npl4 were also found to be up-regulated [1].
  • In the ex-polyQ-expressing cells of the late pupa, an upregulation of ter94 expression was observed prior to cell death [2].
  • Identification of ter94, Drosophila VCP, as a modulator of polyglutamine-induced neurodegeneration [2].
  • Interestingly, when ter94 was overexpressed in the eye by increasing the transgene copies, severe eye degeneration was induced [2].
  • The presence of TER94 suggests that the fusome cisternae grow by vesicle fusion and are a germ cell modification of endoplasmic reticulum [3].
 

Biological context of TER94

  • We also show that fusome association of TER94 is Bam-dependent, suggesting that cystoblast differentiation may be linked to fusome reticulum biogenesis [3].
  • TER94 is expressed in embryo, in pupae and in imago, but is suppressed in larva [4].
  • On the basis of its distribution we suggest that TER94 functions in the protein transport utilizing endoplasmic reticulum and Golgi derived vesicles [4].
  • TER94, a Drosophila homolog of the membrane fusion protein CDC48/p97, is accumulated in nonproliferating cells: in the reproductive organs and in the brain of the imago [4].
  • The open reading frame of the Drosophila homolog encodes an 801 amino acid long protein (TER94), which shows high similarity to the known CDC48/p97 sequences [4].
 

Anatomical context of TER94

  • TER94/p47 staining was observed in the nurse cells and often in the oöcytes, while TER94/p98 staining was present in the sperm bundles [4].
  • Besides TER94, sex-specific forms were also detected in the gonads of the imago: p47 in the ovaries and p98 in the testis [4].
 

Other interactions of TER94

  • We identified mutations in ter94 which disrupt the localization of oskar mRNA to the posterior pole of the oocyte [5].

References

  1. Identification and characterization of a Drosophila proteasome regulatory network. Lundgren, J., Masson, P., Mirzaei, Z., Young, P. Mol. Cell. Biol. (2005) [Pubmed]
  2. Identification of ter94, Drosophila VCP, as a modulator of polyglutamine-induced neurodegeneration. Higashiyama, H., Hirose, F., Yamaguchi, M., Inoue, Y.H., Fujikake, N., Matsukage, A., Kakizuka, A. Cell Death Differ. (2002) [Pubmed]
  3. Identification of TER94, an AAA ATPase protein, as a Bam-dependent component of the Drosophila fusome. León, A., McKearin, D. Mol. Biol. Cell (1999) [Pubmed]
  4. TER94, a Drosophila homolog of the membrane fusion protein CDC48/p97, is accumulated in nonproliferating cells: in the reproductive organs and in the brain of the imago. Pintér, M., Jékely, G., Szepesi, R.J., Farkas, A., Theopold, U., Meyer, H.E., Lindholm, D., Nässel, D.R., Hultmark, D., Friedrich, P. Insect Biochem. Mol. Biol. (1998) [Pubmed]
  5. Membrane fusion proteins are required for oskar mRNA localization in the Drosophila egg chamber. Ruden, D.M., Sollars, V., Wang, X., Mori, D., Alterman, M., Lu, X. Dev. Biol. (2000) [Pubmed]
 
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