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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

HSP60  -  heat shock protein 60

Arabidopsis thaliana

Synonyms: HEAT SHOCK PROTEIN 60-3B, HSP60-3B
 
 
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High impact information on HSP60

  • Cpn10 is a co-factor of Cpn60, which regulates Cpn60-mediated protein folding [1].
  • Mitochondria contain a nuclear-encoded heat shock protein, HSP60, which functions as a chaperonin in the post-translational assembly of multimeric proteins encoded by both nuclear and mitochondrial genes [2].
  • Based on the functional role of HSP60 in macromolecular assembly, these data collectively suggest that the presence of higher levels of HSP60 is necessary during active mitochondrial biogenesis, when the need for this protein is greatest in assisting the rapid assembly of the oligomeric protein structures [2].
  • cDNA clones encoding Arabidopsis thaliana and Zea mays mitochondrial chaperonin HSP60 and gene expression during seed germination and heat shock [2].
  • Southern-blot analysis indicates the presence of a single hsp60 gene in the genome of A. thaliana [2].
 

Analytical, diagnostic and therapeutic context of HSP60

  • Northern- and western-blot analyses indicate that the expression of the hsp60 gene is developmentally regulated during seed germination [2].

References

  1. Isolation and characterization of a cDNA encoding mitochondrial chaperonin 10 from Arabidopsis thaliana by functional complementation of an Escherichia coli groES mutant. Koumoto, Y., Tsugeki, R., Shimada, T., Mori, H., Kondo, M., Hara-Nishimura, I., Nishimura, M. Plant J. (1996) [Pubmed]
  2. cDNA clones encoding Arabidopsis thaliana and Zea mays mitochondrial chaperonin HSP60 and gene expression during seed germination and heat shock. Prasad, T.K., Stewart, C.R. Plant Mol. Biol. (1992) [Pubmed]
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