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Gene Review:

GSK1 - shaggy-related protein kinase iota

Arabidopsis thaliana

Synonyms: ATGSK1, ATSK2-3, ATSK22, BIL2, BIN2-LIKE 2, ...

Piao, H.L. et al., Piao, H.L. et al., Dornelas, M.C. et al., Yoo, M.J. et al., Jonak, C. et al.

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High impact information on GSK1

Analysis of the Arabidopsis genome revealed the existence of ten GSK genes that fall into four distinct subfamilies [1].
Taken together, these results suggest that AtGSK1 is involved in the signal transduction pathway(s) of NaCl stress responses in Arabidopsis [2].
Northern blotting revealed that AtGSK1 over-expression induced expression of the NaCl stress-responsive genes AtCP1, RD29A and CHS1 in the absence of NaCl stress [2].
By functional complementation of the yeast calcineurin mutant strain DHT22-1a with a NaCl stress-sensitive phenotype, we isolated the Arabidopsis cDNA AtGSK1, which encodes a GSK3/shaggy-like protein kinase [3].
In addition, the AtGSK1 expression was induced by NaCl and exogenously applied ABA but not by KCl [3].

Biological context of GSK1

In this paper we report the characterization of three novel members of the Arabidopsis shaggy-related protein kinase (ASK) multigene family, named ASKdzeta (ASKzeta), ASKetha (ASKeta) and ASKiota (ASKiota) [4].
ESTs from basal angiosperms were represented in all four major clades; GSK homologs from the basal angiosperm Persea americana (avocado) appeared in all four clades [5].

References

Glycogen synthase kinase 3/SHAGGY-like kinases in plants: an emerging family with novel functions. Jonak, C., Hirt, H. Trends Plant Sci. (2002) [Pubmed]
Constitutive over-expression of AtGSK1 induces NaCl stress responses in the absence of NaCl stress and results in enhanced NaCl tolerance in Arabidopsis. Piao, H.L., Lim, J.H., Kim, S.J., Cheong, G.W., Hwang, I. Plant J. (2001) [Pubmed]
An Arabidopsis GSK3/shaggy-like gene that complements yeast salt stress-sensitive mutants is induced by NaCl and abscisic acid. Piao, H.L., Pih, K.T., Lim, J.H., Kang, S.G., Jin, J.B., Kim, S.H., Hwang, I. Plant Physiol. (1999) [Pubmed]
Characterization of three novel members of the Arabidopsis SHAGGY-related protein kinase (ASK) multigene family. Dornelas, M.C., Wittich, P., von Recklinghausen, I., van Lammeren, A., Kreis, M. Plant Mol. Biol. (1999) [Pubmed]
Phylogenetic diversification of glycogen synthase kinase 3/SHAGGY-like kinase genes in plants. Yoo, M.J., Albert, V.A., Soltis, P.S., Soltis, D.E. BMC Plant Biol. (2006) [Pubmed]

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