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Psychiatry related information on Persea

  • The aqueous extract of Persea americana leaves produced a dose-dependent inhibition of both phases of formalin pain test in mice, a reduction in mouse writhing induced by acetic acid and an elevation of pain threshold in the hot plate test in mice [1].

High impact information on Persea

  • Avocado (Persea americana Mill. cv Lula) is a climacteric fruit that exhibits a rise in ethylene as the fruit ripens [2].
  • The NADPH-linked 3-oxoacyl-(acyl-carrier protein) (ACP) reductase (EC, also known as 'beta-ketoacyl-ACP reductase', has been purified from the mesocarp of mature avocado pears (Persea americana) [3].
  • Preparations of acetyl-CoA carboxylase [acetyl-CoA-carbon-dioxide ligase (ADP-forming), EC] have been obtained from the plastids of avocado (Persea americana) fruit mesocarp and from spinach (Spinacia oleracea) chloroplasts [4].
  • To know the mechanisms involved in the activation of promutagenic aromatic amines mediated by plants, we used Persea americana S117 system (S117) for the activation of 2-aminofluorene (2-AF) and m-phenylenediamine (m-PDA) in Ames assays [5].
  • A plant metabolic activation system from Persea americana with cytochrome P450-dependent and peroxidase activities [6].

Anatomical context of Persea


Associations of Persea with chemical compounds


Gene context of Persea

  • Sequence comparison revealed that the N-terminal half of Avicelase I is closely related to avocado (Persea americana) cellulase [11].
  • One known, (2R)-(12Z,15Z)-2-hydroxy-4-oxoheneicosa-12,15-dien+ ++-1-yl acetate (1), and two novel compounds, persenone A (2) and B (3), have been isolated from avocado fruit (Persea americana P. Mill), as inhibitors of superoxide (O(2)(-)) and nitric oxide (NO) generation in cell culture systems [12].
  • Acetyl-CoA carboxylase inhibitors from avocado (Persea americana Mill) fruits [13].
  • The contribution of xanthine dehydrogenase (XDH, EC to fruit size was investigated using the normal and small-fruit variants of Persea americana Mill. cv. 'Hass'. Inhibition of XDH by treatment of normal fruit, in the linear phase of growth (phase II), with allopurinol (Allo) arrested fruit growth [14].
  • The hypoglycaemic and anti-hyperglycemic activities of dried leaves of Loranthus micranthus (Linn.) (Loranthaceae), parasitic on Persea americana, Baphia nitda, Kola acuminata, Pentaclethra macrophylla, Azadirchta indica, were evaluated in normoglycemic and alloxan-induced diabetic albino rats [15].

Analytical, diagnostic and therapeutic context of Persea


  1. Analgesic and anti-inflammatory effects of the aqueous extract of leaves of Persea americana mill (lauraceae). Adeyemi, O.O., Okpo, S.O., Ogunti, O.O. Fitoterapia (2002) [Pubmed]
  2. Characterization of the 9-cis-epoxycarotenoid dioxygenase gene family and the regulation of abscisic acid biosynthesis in avocado. Chernys, J.T., Zeevaart, J.A. Plant Physiol. (2000) [Pubmed]
  3. 3-Oxoacyl-(acyl-carrier protein) reductase from avocado (Persea americana) fruit mesocarp. Sheldon, P.S., Kekwick, R.G., Sidebottom, C., Smith, C.G., Slabas, A.R. Biochem. J. (1990) [Pubmed]
  4. Acetyl-coenzyme A carboxylase from avocado (Persea americana) plastids and spinach (Spinacia oleracea) chloroplasts. Mohan, S.B., Kekwick, R.G. Biochem. J. (1980) [Pubmed]
  5. Plant activation of aromatic amines mediated by cytochromes P450 and flavin-containing monooxygenases. Chiapella, C., Radovan, R.D., Moreno, J.A., Casares, L., Barbé, J., Llagostera, M. Mutat. Res. (2000) [Pubmed]
  6. A plant metabolic activation system from Persea americana with cytochrome P450-dependent and peroxidase activities. Chiapella, C., Ysern, P., Riera, J., Llagostera, M. Mutat. Res. (1995) [Pubmed]
  7. N-demethylation of p-chloro-N-methylaniline catalyzed by subcellular fractions from the avocado pear (Persea americana). Dohn, D.R., Krieger, R.I. Arch. Biochem. Biophys. (1984) [Pubmed]
  8. Majorenolide and majorynolide: a new pair of cytotoxic and pesticidal alkene-alkyne delta-lactones from Persea major. Ma, W.W., Anderson, J.E., Chang, C.J., Smith, D.L., McLaughlin, J.L. J. Nat. Prod. (1989) [Pubmed]
  9. Lectin-like activity from Persea americana. Meade, N.A., Staat, R.H., Langley, S.D., Doyle, R.J. Carbohydr. Res. (1980) [Pubmed]
  10. Effects of preincubation invitro with 3, 4-benzopyrene and phenobarbital on the drug-metabolism systems present in the microsomal and soluble fractions of the avocado pear (Persea americana). McPherson, F.J., Markham, A., Bridges, J.W., Hartman, G.C., Parke, D.V. Biochem. Soc. Trans. (1975) [Pubmed]
  11. Sequence analysis of the Clostridium stercorarium celZ gene encoding a thermoactive cellulase (Avicelase I): identification of catalytic and cellulose-binding domains. Jauris, S., Rücknagel, K.P., Schwarz, W.H., Kratzsch, P., Bronnenmeier, K., Staudenbauer, W.L. Mol. Gen. Genet. (1990) [Pubmed]
  12. Novel nitric oxide and superoxide generation inhibitors, persenone A and B, from avocado fruit. Kim, O.K., Murakami, A., Nakamura, Y., Takeda, N., Yoshizumi, H., Ohigashi, H. J. Agric. Food Chem. (2000) [Pubmed]
  13. Acetyl-CoA carboxylase inhibitors from avocado (Persea americana Mill) fruits. Hashimura, H., Ueda, C., Kawabata, J., Kasai, T. Biosci. Biotechnol. Biochem. (2001) [Pubmed]
  14. Xanthine dehydrogenase and aldehyde oxidase impact plant hormone homeostasis and affect fruit size in 'Hass' avocado. Taylor, N.J., Cowan, A.K. J. Plant Res. (2004) [Pubmed]
  15. Study on anti-diabetic activities of crude methanolic extracts of Loranthus micranthus (Linn.) sourced from five different host trees. Osadebe, P.O., Okide, G.B., Akabogu, I.C. Journal of ethnopharmacology. (2004) [Pubmed]
  16. Determination by near-infrared spectroscopy of perseitol used as a marker for the botanical origin of avocado (Persea americana Mill.) honey. Dvash, L., Afik, O., Shafir, S., Schaffer, A., Yeselson, Y., Dag, A., Landau, S. J. Agric. Food Chem. (2002) [Pubmed]
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