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Gene Review

unc-18  -  Protein UNC-18

Caenorhabditis elegans

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Disease relevance of unc-18


High impact information on unc-18


Biological context of unc-18


Anatomical context of unc-18


Associations of unc-18 with chemical compounds


Other interactions of unc-18

  • Alleles of dyf-2 and unc-13 were isolated, and mutants of unc-18, a gene that interacts with unc-13, were also found to be long lived [11].
  • Here we describe the cloning, and the molecular and genetic characterization of the unc-64 gene, especially in relation to unc-18. unc-64 encodes a protein (C. elegans syntaxin) showing sequence and structural similarities to mammalian syntaxin 1A [1].


  1. Functional properties of the unc-64 gene encoding a Caenorhabditis elegans syntaxin. Ogawa, H., Harada, S., Sassa, T., Yamamoto, H., Hosono, R. J. Biol. Chem. (1998) [Pubmed]
  2. Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin. Hata, Y., Slaughter, C.A., Südhof, T.C. Nature (1993) [Pubmed]
  3. The C. elegans unc-18 gene encodes a protein expressed in motor neurons. Gengyo-Ando, K., Kamiya, Y., Yamakawa, A., Kodaira, K., Nishiwaki, K., Miwa, J., Hori, I., Hosono, R. Neuron (1993) [Pubmed]
  4. A murine neural-specific homolog corrects cholinergic defects in Caenorhabditis elegans unc-18 mutants. Gengyo-Ando, K., Kitayama, H., Mukaida, M., Ikawa, Y. J. Neurosci. (1996) [Pubmed]
  5. The unc-18 gene encodes a novel protein affecting the kinetics of acetylcholine metabolism in the nematode Caenorhabditis elegans. Hosono, R., Hekimi, S., Kamiya, Y., Sassa, T., Murakami, S., Nishiwaki, K., Miwa, J., Taketo, A., Kodaira, K.I. J. Neurochem. (1992) [Pubmed]
  6. Regulation of the UNC-18-Caenorhabditis elegans syntaxin complex by UNC-13. Sassa, T., Harada, S., Ogawa, H., Rand, J.B., Maruyama, I.N., Hosono, R. J. Neurosci. (1999) [Pubmed]
  7. Initiation of male sperm-transfer behavior in Caenorhabditis elegans requires input from the ventral nerve cord. Schindelman, G., Whittaker, A.J., Thum, J.Y., Gharib, S., Sternberg, P.W. BMC Biol. (2006) [Pubmed]
  8. Defects in synaptic vesicle docking in unc-18 mutants. Weimer, R.M., Richmond, J.E., Davis, W.S., Hadwiger, G., Nonet, M.L., Jorgensen, E.M. Nat. Neurosci. (2003) [Pubmed]
  9. Molecular characterization of a nonneuronal human UNC18 homolog. Ziegler, S.F., Mortrud, M.T., Swartz, A.R., Baker, E., Sutherland, G.R., Burmeister, M., Mulligan, J.T. Genomics (1996) [Pubmed]
  10. A novel isoform of syntaxin-binding protein homologous to yeast Sec1 expressed ubiquitously in mammalian cells. Katagiri, H., Terasaki, J., Murata, T., Ishihara, H., Ogihara, T., Inukai, K., Fukushima, Y., Anai, M., Kikuchi, M., Miyazaki, J. J. Biol. Chem. (1995) [Pubmed]
  11. Positive selection of Caenorhabditis elegans mutants with increased stress resistance and longevity. Muñoz, M.J., Riddle, D.L. Genetics (2003) [Pubmed]
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