The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

nr5a1a  -  nuclear receptor subfamily 5, group A,...

Danio rerio

Synonyms: SF1-A, SO:0000704, ff1b, nr5a4
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on nr5a1a

  • In situ hybridization demonstrates that prox1 colocalizes with ff1a and ff1b in the liver and interrenal primordia, respectively [1].
  • Our gene knockdown experiments indicate that wt1 is required for its initial restricted expression in pronephric primordia, pronephric cell migration and fusion. wt1 also appears to be involved in interrenal development and ff1b expression [2].
  • Similarly, ff1b is required for interrenal differentiation and activation of the differentiated gene, cyp11a1 [2].
  • Primordial interrenal cells first appear as bilateral intermediate mesoderm expressing ff1b in a region ventral to the third somite [2].
  • The zebrafish ftz-f1 gene, ff1b, is activated in two cell clusters lateral to the midline in the trunk during late embryogenesis [3].

Biological context of nr5a1a


Anatomical context of nr5a1a


Associations of nr5a1a with chemical compounds


Other interactions of nr5a1a

  • Among them, the ff1a expression pattern is similar to mammalian Nr5a2, while the ff1b pattern is similar to that of mammalian Nr5a1 [5].

Analytical, diagnostic and therapeutic context of nr5a1a

  • Comparative sequence analysis showed that zFF1 exhibited higher sequence similarity to the LRH/FTF group than the SF-1/Ad4BP group, whereas ff1b was indistinguishable between the groups [6].


  1. Prox1 is a novel coregulator of Ff1b and is involved in the embryonic development of the zebra fish interrenal primordium. Liu, Y.W., Gao, W., Teh, H.L., Tan, J.H., Chan, W.K. Mol. Cell. Biol. (2003) [Pubmed]
  2. Parallel early development of zebrafish interrenal glands and pronephros: differential control by wt1 and ff1b. Hsu, H.J., Lin, G., Chung, B.C. Development (2003) [Pubmed]
  3. Ff1b is required for the development of steroidogenic component of the zebrafish interrenal organ. Chai, C., Liu, Y.W., Chan, W.K. Dev. Biol. (2003) [Pubmed]
  4. Novel steroidogenic factor-1 homolog (ff1d) is coexpressed with anti-Mullerian hormone (AMH) in zebrafish. von Hofsten, J., Larsson, A., Olsson, P.E. Dev. Dyn. (2005) [Pubmed]
  5. Gene duplication, gene loss and evolution of expression domains in the vertebrate nuclear receptor NR5A (Ftz-F1) family. Kuo, M.W., Postlethwait, J., Lee, W.C., Lou, S.W., Chan, W.K., Chung, B.C. Biochem. J. (2005) [Pubmed]
  6. Developmental expression patterns of FTZ-F1 homologues in zebrafish (Danio rerio). von Hofsten, J., Jones, I., Karlsson, J., Olsson, P.E. Gen. Comp. Endocrinol. (2001) [Pubmed]
WikiGenes - Universities