High impact information on cyp11a1

• Similarly, ff1b is required for interrenal differentiation and activation of the differentiated gene, cyp11a1 [1].
• Until 2 d post fertilization (2 dpf) interrenal development assessed by transcripts of key steroidogenic genes (cyp11a1, mc2r, star) is independent of proopiomelanocortin (Pomc) as demonstrated in aal/eya1and lia/fgf3 mutants [2].
• When cyp11a1 activity was compensated by the injection of antisense morpholino oligos, the embryos have shortened axis and a defect of epibolic cell movement during early embryogenesis [3].
• Zebrafish with a block in cyp11a1 gene function has an earlier defect, presumably because it lacks adequate maternal steroid supply [3].
• Zebrafish cyp11a1 is expressed in the gonads and interrenal glands in the adults, similar to mammals [4].

Biological context of cyp11a1

• To study steroidogenesis in embryos, we have isolated the zebrafish cyp11a1 gene, which consists of 11 exons [5].

Anatomical context of cyp11a1

• In addition, zebrafish cyp11a1 is expressed in oocytes, and is inherited as a maternal transcript in early embryos [5].
• At 36 h post fertilization, cyp11a1 transcript is located ventral to the third somite, where the primordial interrenal gland is located [5].

Associations of cyp11a1 with chemical compounds

• This epibolic defect was partially rescued by the injection of cyp11a1 RNA or the supplementation of pregnenolone [6].

References