The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

cyp11a1  -  cytochrome P450, family 11, subfamily A,...

Danio rerio

Synonyms: P450scc, SO:0000704, cb957, wu:fj97d10
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on cyp11a1

  • Similarly, ff1b is required for interrenal differentiation and activation of the differentiated gene, cyp11a1 [1].
  • Until 2 d post fertilization (2 dpf) interrenal development assessed by transcripts of key steroidogenic genes (cyp11a1, mc2r, star) is independent of proopiomelanocortin (Pomc) as demonstrated in aal/eya1and lia/fgf3 mutants [2].
  • When cyp11a1 activity was compensated by the injection of antisense morpholino oligos, the embryos have shortened axis and a defect of epibolic cell movement during early embryogenesis [3].
  • Zebrafish with a block in cyp11a1 gene function has an earlier defect, presumably because it lacks adequate maternal steroid supply [3].
  • Zebrafish cyp11a1 is expressed in the gonads and interrenal glands in the adults, similar to mammals [4].

Biological context of cyp11a1


Anatomical context of cyp11a1


Associations of cyp11a1 with chemical compounds

  • This epibolic defect was partially rescued by the injection of cyp11a1 RNA or the supplementation of pregnenolone [6].


  1. Parallel early development of zebrafish interrenal glands and pronephros: differential control by wt1 and ff1b. Hsu, H.J., Lin, G., Chung, B.C. Development (2003) [Pubmed]
  2. Pituitary-interrenal interaction in zebrafish interrenal organ development. To, T.T., Hahner, S., Nica, G., Rohr, K.B., Hammerschmidt, M., Winkler, C., Allolio, B. Mol. Endocrinol. (2007) [Pubmed]
  3. Steroidogenesis in zebrafish and mouse models. Hsu, H.J., Hsu, N.C., Hu, M.C., Chung, B.C. Mol. Cell. Endocrinol. (2006) [Pubmed]
  4. Function of Cyp11a1 in animal models. Hu, M.C., Hsu, H.J., Guo, I.C., Chung, B.C. Mol. Cell. Endocrinol. (2004) [Pubmed]
  5. Expression of zebrafish cyp11a1 as a maternal transcript and in yolk syncytial layer. Hsu, H.J., Hsiao, P., Kuo, M.W., Chung, B.C. Gene Expr. Patterns (2002) [Pubmed]
  6. Pregnenolone stabilizes microtubules and promotes zebrafish embryonic cell movement. Hsu, H.J., Liang, M.R., Chen, C.T., Chung, B.C. Nature (2006) [Pubmed]
WikiGenes - Universities