Disease relevance of Interrenal Gland

• 1) FSH treatment (3 microg/100 g body wt daily for 10 days) caused interrenal hypertrophy with increased nuclear diameter, raises of acid phosphatase and alkaline phosphatase concentrations, and depletions of cholesterol (except the free fraction) and ascorbic acid levels from the interrenal gland [1].

High impact information on Interrenal Gland

• Cortisol, when incubated with an active source of this oxidase, the bullfrog interrenal gland, was converted to 18-hydroxycortisol and a new C-18-oxygenated steroid identified as 11 beta, 17 alpha,21-trihydroxy-3,20-diketo-4-pregnene-18-al, or 18-oxocortisol [2].
• Role of exogenous and endogenous prostaglandins in steroidogenesis by isolated frog interrenal gland: evidence for dissociation in adrenocorticotropin and angiotensin action [3].
• Both frog/human ET-1, frog ET-3 and human ET-3 produced a concentration-dependent increase in the production of corticosteroids from perifused slices of the frog interrenal gland [4].
• Effects of TMB-8 and dantrolene on ACTH- and angiotensin-induced steroidogenesis by frog interrenal gland: evidence for a role of intracellular calcium in angiotensin action [5].
• In vitro effect of prostaglandins on corticosterone and aldosterone production by frog interrenal gland [6].

Anatomical context of Interrenal Gland

• It is postulated that the interrenal gland activity could substitute or supplement androgen production by the testes [7].
• The interrenal gland (the homologue of the mammalian adrenal cortex) of elasmobranchs (sharks, skates, and rays) produces 1alpha-hydroxycorticosterone (1alpha-B), which has been reported to function both as a gluco- and mineralocorticosteroid [8].
• The specific binding of ANG II in elasmobranchs has been reported in gills, heart, interrenal gland, gut and rectal gland [9].

Associations of Interrenal Gland with chemical compounds

• Comparative effects of canrenoate-K and prorenoate-K upon aldosterone biosynthesis in perifused frog interrenal glands [10].
• Pituitary adenylate cyclase-activating peptide enhances steroid production by interrenal glands in fowls: evidence for an indirect mechanism of action [11].
• In addition, there is considerable binding to the interrenal gland and the stimulation of 1alpha-hydroxycorticosterone production in vitro suggests a physiological role in corticosteroidogenesis [12].
• Our results suggest that in coho salmon, cortisol may exert ultra-short-loop negative feedback directly at the level of the interrenal gland to effect self-suppression [13].
• Regulation of interrenal gland steroidogenesis in the Atlantic stingray (Dasyatis sabina) [8].

Gene context of Interrenal Gland

• Physiological studies have demonstrated that ANG II in elasmobranchs is vasopressor, and stimulates interrenal gland production of the elasmobranch corticosteroid 1alpha-hydroxycorticosterone [9].
• These changes were not observed in the interrenal gland of LHRH treated hypophysectomized frogs [14].
• A role for renin in stimulating interrenal gland steroid biosynthesis and in influencing water and ion regulation in nonmammalian vertebrates is discussed [15].

References