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Gene Review

Abcc1  -  ATP-binding cassette, sub-family C...

Mus musculus

Synonyms: ATP-binding cassette sub-family C member 1, Abcc1a, Abcc1b, LTC4 transporter, Leukotriene C(4) transporter, ...
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Disease relevance of Abcc1


High impact information on Abcc1


Chemical compound and disease context of Abcc1


Biological context of Abcc1


Anatomical context of Abcc1


Associations of Abcc1 with chemical compounds


Regulatory relationships of Abcc1

  • Moreover, Mrp1 was rather expressed than P-gp in parenchyma astrocytes and in glia limitans lining the meninges [16].
  • The MRP/plf-mRNA species expressed in the skin were predominantly plf1 and mrp3 as determined by gene-specific restriction enzyme sites within the RT-PCR products [22].

Other interactions of Abcc1

  • However, the mechanisms by which the Oatp and Mrp genes are down-regulated are largely unknown [23].
  • Indeed, choroidal and ependymal cells expressed Mrp1 rather than P-gp [16].
  • No significant difference was observed in the expression of MDR1a, Mdr1b and Mrp-1 genes between wMNB and rMNB-MDL cells, however, a slight decrease was noticed in Mdr1 expression in some samples [24].
  • TR-BBB cells express the mRNA of multidrug resistance associated protein 1 (MRP1) and a large neutral amino acid transporter, which consists of LAT1 and 4F2hc [25].
  • The expression levels of Mrp/Plf mRNAs in mouse brains were low during the neonatal period, but higher in embryonic and adult stages, indicating Mrp/Plfs expression profiles are different in mouse brain and placenta [4].

Analytical, diagnostic and therapeutic context of Abcc1


  1. Identification of the biosynthetic leukotriene C4 export pump in murine mastocytoma cells as a homolog of the multidrug-resistance protein. Leier, I., Jedlitschky, G., Büchler, M., Buchholz, U., Brom, M., Keppler, D. Eur. J. Biochem. (1996) [Pubmed]
  2. Expression of P-glycoprotein and multidrug resistance associated protein in Ehrlich ascites tumor cells after fractionated irradiation. Nielsen, D., Maare, C., Eriksen, J., Litman, T., Skovsgaard, T. Int. J. Radiat. Oncol. Biol. Phys. (2001) [Pubmed]
  3. Expression and activity of multidrug resistance protein 1 in a murine thymoma cell line. Echevarria-Lima, J., Kyle-Cezar, F., P Leite, D.F., Capella, L., Capella, M.A., Rumjanek, V.M. Immunology (2005) [Pubmed]
  4. Proliferin enhances microvilli formation and cell growth of neuroblastoma cells. Wang, J.W., Jiang, Y.N., Huang, C.Y., Huang, P.Y., Huang, M.C., Cheng, W.T., Shen, C.K., Ju, Y.T. Neurosci. Res. (2006) [Pubmed]
  5. Expression and regulation of breast cancer resistance protein and multidrug resistance associated protein 2 in BALB/c mice. Han, Y., Sugiyama, Y. Biol. Pharm. Bull. (2006) [Pubmed]
  6. Mouse RNAase MRP RNA is encoded by a nuclear gene and contains a decamer sequence complementary to a conserved region of mitochondrial RNA substrate. Chang, D.D., Clayton, D.A. Cell (1989) [Pubmed]
  7. Yeast site-specific ribonucleoprotein endoribonuclease MRP contains an RNA component homologous to mammalian RNase MRP RNA and essential for cell viability. Schmitt, M.E., Clayton, D.A. Genes Dev. (1992) [Pubmed]
  8. Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier. Wijnholds, J., deLange, E.C., Scheffer, G.L., van den Berg, D.J., Mol, C.A., van der Valk, M., Schinkel, A.H., Scheper, R.J., Breimer, D.D., Borst, P. J. Clin. Invest. (2000) [Pubmed]
  9. Intraabdominal sepsis down-regulates transcription of sodium taurocholate cotransporter and multidrug resistance-associated protein in rats. Kim, P.K., Chen, J., Andrejko, K.M., Deutschman, C.S. Shock (2000) [Pubmed]
  10. Chemoprotection and selection by chemotherapy of multidrug resistance-associated protein-1 (MRP1) transduced cells. D'Hondt, V., Symann, M., Machiels, J.P. Current gene therapy. (2001) [Pubmed]
  11. Bilirubin protects astrocytes from its own toxicity by inducing up-regulation and translocation of multidrug resistance-associated protein 1 (Mrp1). Gennuso, F., Fernetti, C., Tirolo, C., Testa, N., L'Episcopo, F., Caniglia, S., Morale, M.C., Ostrow, J.D., Pascolo, L., Tiribelli, C., Marchetti, B. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  12. Mucosal vaccination of mice with recombinant Proteus mirabilis structural fimbrial proteins. Scavone, P., Sosa, V., Pellegrino, R., Galvalisi, U., Zunino, P. Microbes Infect. (2004) [Pubmed]
  13. The influence of coordinate overexpression of glutathione phase II detoxification gene products on drug resistance. O'Brien, M., Kruh, G.D., Tew, K.D. J. Pharmacol. Exp. Ther. (2000) [Pubmed]
  14. Expression of multidrug resistance proteins (Mrps) in astrocytes of the mouse brain: a single cell RT-PCR study. Hirrlinger, J., Moeller, H., Kirchhoff, F., Dringen, R. Neurochem. Res. (2005) [Pubmed]
  15. Mrp4-/- mice have an impaired cytoprotective response in obstructive cholestasis. Mennone, A., Soroka, C.J., Cai, S.Y., Harry, K., Adachi, M., Hagey, L., Schuetz, J.D., Boyer, J.L. Hepatology (2006) [Pubmed]
  16. Expression of P-glycoprotein (ABCB1) and Mrp1 (ABCC1) in adult rat brain: focus on astrocytes. Mercier, C., Masseguin, C., Roux, F., Gabrion, J., Scherrmann, J.M. Brain Res. (2004) [Pubmed]
  17. Kinetic and biochemical analysis of carrier-mediated efflux of drugs through the blood-brain and blood-cerebrospinal fluid barriers: importance in the drug delivery to the brain. Sugiyama, Y., Kusuhara, H., Suzuki, H. Journal of controlled release : official journal of the Controlled Release Society. (1999) [Pubmed]
  18. Evaluation of the role of multidrug resistance-associated protein (mrp) 3 and mrp4 in hepatic basolateral excretion of sulfate and glucuronide metabolites of acetaminophen, 4-methylumbelliferone, and harmol in abcc3-/- and abcc4-/- mice. Zamek-Gliszczynski, M.J., Nezasa, K., Tian, X., Bridges, A.S., Lee, K., Belinsky, M.G., Kruh, G.D., Brouwer, K.L. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  19. Do multidrug resistance-associated protein-1 and -2 play any role in the elimination of estradiol-17 beta-glucuronide and 2,4-dinitrophenyl-S-glutathione across the blood-cerebrospinal fluid barrier? Lee, Y.J., Kusuhara, H., Sugiyama, Y. Journal of pharmaceutical sciences. (2004) [Pubmed]
  20. Extensive contribution of the multidrug transporters P-glycoprotein and Mrp1 to basal drug resistance. Allen, J.D., Brinkhuis, R.F., van Deemter, L., Wijnholds, J., Schinkel, A.H. Cancer Res. (2000) [Pubmed]
  21. Leukotriene C4 secretion from normal murine mast cells by a probenecid-sensitive and multidrug resistance-associated protein-independent mechanism. Nguyen, T., Gupta, S. J. Immunol. (1997) [Pubmed]
  22. Mitogen-regulated protein/proliferin mRNA induction following single applications of tumor promoters to murine skin. Parfett, C.L. Mol. Carcinog. (2005) [Pubmed]
  23. Inflammatory cytokines, but not bile acids, regulate expression of murine hepatic anion transporters in endotoxemia. Hartmann, G., Cheung, A.K., Piquette-Miller, M. J. Pharmacol. Exp. Ther. (2002) [Pubmed]
  24. DNA (cytosine) methyltransferase overexpression is associated with acquired drug resistance of murine neuroblastoma cells. Wang, C., Mirkin, B.L., Dwivedi, R.S. Int. J. Oncol. (2001) [Pubmed]
  25. Conditionally immortalized cell lines as a new in vitro model for the study of barrier functions. Terasaki, T., Hosoya, K. Biol. Pharm. Bull. (2001) [Pubmed]
  26. Multiple resistance mechanisms in Chinese hamster cells resistant to 9-hydroxyellipticine. Larsen, A.K., Jacquemin-Sablon, A. Cancer Res. (1989) [Pubmed]
  27. Evidence that the multidrug resistance protein (MRP) functions as a co-transporter of glutathione and natural product toxins. Rappa, G., Lorico, A., Flavell, R.A., Sartorelli, A.C. Cancer Res. (1997) [Pubmed]
  28. Tissue and cell distribution of the multidrug resistance-associated protein (MRP) in mouse intestine and kidney. Peng, K.C., Cluzeaud, F., Bens, M., Van Huyen, J.P., Wioland, M.A., Lacave, R., Vandewalle, A. J. Histochem. Cytochem. (1999) [Pubmed]
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