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Gene Review

ZCCHC7  -  zinc finger, CCHC domain containing 7

Homo sapiens

Synonyms: AIR1, FLJ22611, HSPC086, TRAMP-like complex RNA-binding factor ZCCHC7, Zinc finger CCHC domain-containing protein 7
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Disease relevance of ZCCHC7


High impact information on ZCCHC7


Biological context of ZCCHC7

  • HLA class II expression in uninducible hepatocarcinoma cells after transfection of AIR-1 gene product CIITA: acquisition of antigen processing and presentation capacity [7].
  • The expression of HLA class II genes is under the control of a transcriptional activator, CIITA, encoded by the AIR-1 locus [8].
  • The fact that this promoter is inactive in the RJ2.2.5 mutant suggests that the trans-acting element determined by the AIR-1 locus is not only an enhancer factor as previously described, but also acts at the MHC class II promoter level [6].

Anatomical context of ZCCHC7


Other interactions of ZCCHC7


  1. In vivo modification of major histocompatibility complex class II DRA promoter occupancy mediated by the AIR-1 trans-activator. Rigaud, G., Paiola, F., Accolla, R.S. Eur. J. Immunol. (1994) [Pubmed]
  2. Active suppression of the class II transactivator-encoding AIR-1 locus is responsible for the lack of major histocompatibility complex class II gene expression observed during differentiation from B cells to plasma cells. Sartoris, S., Tosi, G., De Lerma Barbaro, A., Cestari, T., Accolla, R.S. Eur. J. Immunol. (1996) [Pubmed]
  3. Analysis of CIITA encoding AIR-1 gene promoters in insulin-dependent diabetes mellitus and rheumatoid arthritis patients from the northeast of Italy: absence of sequence variability. Sartoris, S., Brendolan, A., Degola, A., Testi, M.G., Chignola, R., Scarpa, A., Scardoni, M., Contreas, G., Pinelli, L., Lunardi, C., Beri, R., Pera, C., Ferrara, G.B., Riviera, A.P., Tridente, G., Andrighetto, G. Hum. Immunol. (2000) [Pubmed]
  4. The MHC class II transcriptional activator (CIITA) inhibits HTLV-2 viral replication by blocking the function of the viral transactivator Tax-2. Casoli, C., De Lerma Barbaro, A., Pilotti, E., Bertazzoni, U., Tosi, G., Accolla, R.S. Blood (2004) [Pubmed]
  5. Physiologic target of the Air-1 trans-activator revealed by stable transfection assay. Sartoris, S., De Lerma Barbaro, A., Cestari, T., Tridente, G., Accolla, R.S. Immunogenetics (1994) [Pubmed]
  6. Effect of the AIR-1 locus on the activation of an enhancerless HLA-DQA1 promoter. Ombra, M.N., Del Pozzo, G., Perfetto, C., Maffei, A., Guardiola, J. Immunogenetics (1990) [Pubmed]
  7. HLA class II expression in uninducible hepatocarcinoma cells after transfection of AIR-1 gene product CIITA: acquisition of antigen processing and presentation capacity. Sartoris, S., Valle, M.T., Barbaro, A.L., Tosi, G., Cestari, T., D'Agostino, A., Megiovanni, A.M., Manca, F., Accolla, R.S. J. Immunol. (1998) [Pubmed]
  8. The HLA class II transcriptional activator blocks the function of HIV-1 Tat and inhibits viral replication. Accolla, R.S., Mazza, S., De Lerma Barbaro, A., De Maria, A., Tosi, G. Eur. J. Immunol. (2002) [Pubmed]
  9. Identification and characterization of factors required for microtubule growth and nucleation in the early C. elegans embryo. Srayko, M., Kaya, A., Stamford, J., Hyman, A.A. Dev. Cell (2005) [Pubmed]
  10. The AIR-1 encoded class II transactivator (CIITA): the master coordinator of MHC class II gene expression and .. more. Accolla, R.S. Adv. Exp. Med. Biol. (2001) [Pubmed]
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