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Chemical Compound Review

Thiacetamid     ethanethioamide

Synonyms: Thiacetamide, Thioactamide, THIOACETAMIDE, Acetothioamide, CCRIS 584, ...
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Disease relevance of thioacetamide


Psychiatry related information on thioacetamide

  • RESULTS: Compared with normal, saline-treated rats, those receiving consecutive injections of TAA had apparently lower neurobehavioral scores (p < 0.001) accompanied by significantly blunted motor activities (p < 0.001) [6].

High impact information on thioacetamide


Chemical compound and disease context of thioacetamide


Biological context of thioacetamide


Anatomical context of thioacetamide


Associations of thioacetamide with other chemical compounds


Gene context of thioacetamide


Analytical, diagnostic and therapeutic context of thioacetamide


  1. Delivery of matrix metalloproteinase-1 attenuates established liver fibrosis in the rat. Iimuro, Y., Nishio, T., Morimoto, T., Nitta, T., Stefanovic, B., Choi, S.K., Brenner, D.A., Yamaoka, Y. Gastroenterology (2003) [Pubmed]
  2. JTE-522, a cyclooxygenase-2 inhibitor, is an effective chemopreventive agent against rat experimental liver fibrosis1. Yamamoto, H., Kondo, M., Nakamori, S., Nagano, H., Wakasa, K., Sugita, Y., Chang-De, J., Kobayashi, S., Damdinsuren, B., Dono, K., Umeshita, K., Sekimoto, M., Sakon, M., Matsuura, N., Monden, M. Gastroenterology (2003) [Pubmed]
  3. Hepatic encephalopathy in rats with thioacetamide-induced acute liver failure is not mediated by endogenous benzodiazepines. Püspök, A., Herneth, A., Steindl, P., Ferenci, P. Gastroenterology (1993) [Pubmed]
  4. Brain gamma-aminobutyric acid receptor binding is normal in rats with thioacetamide-induced hepatic encephalopathy despite elevated plasma gamma-aminobutyric acid-like activity. Maddison, J.E., Dodd, P.R., Johnston, G.A., Farrell, G.C. Gastroenterology (1987) [Pubmed]
  5. Cholangiocyte endothelin 1 and transforming growth factor beta1 production in rat experimental hepatopulmonary syndrome. Luo, B., Tang, L., Wang, Z., Zhang, J., Ling, Y., Feng, W., Sun, J.Z., Stockard, C.R., Frost, A.R., Chen, Y.F., Grizzle, W.E., Fallon, M.B. Gastroenterology (2005) [Pubmed]
  6. Establishment of an animal model of hepatic encephalopathy. Chu, C.J., Lee, F.Y., Wang, S.S., Chang, F.Y., Lin, H.C., Wu, S.L., Chan, C.C., Tsai, Y.T., Lee, S.D. Zhonghua Yi Xue Za Zhi (Taipei) (2000) [Pubmed]
  7. Induction of ovalbumin synthesis in immature chicks by actinomycin D and thioacetamide. Sharma, O.K. Science (1978) [Pubmed]
  8. Toxicology of thiono-sulfur compounds. Neal, R.A., Halpert, J. Annu. Rev. Pharmacol. Toxicol. (1982) [Pubmed]
  9. The bone marrow functionally contributes to liver fibrosis. Russo, F.P., Alison, M.R., Bigger, B.W., Amofah, E., Florou, A., Amin, F., Bou-Gharios, G., Jeffery, R., Iredale, J.P., Forbes, S.J. Gastroenterology (2006) [Pubmed]
  10. Immune stimulation of hepatic fibrogenesis by CD8 cells and attenuation by transgenic interleukin-10 from hepatocytes. Safadi, R., Ohta, M., Alvarez, C.E., Fiel, M.I., Bansal, M., Mehal, W.Z., Friedman, S.L. Gastroenterology (2004) [Pubmed]
  11. Synaptosomal glutamate transport in thioacetamide-induced hepatic encephalopathy in the rat. Oppong, K.N., Bartlett, K., Record, C.O., al Mardini, H. Hepatology (1995) [Pubmed]
  12. Increased benzodiazepine-like activity is neither necessary nor sufficient to explain acute hepatic encephalopathy in the thioacetamide-treated rat. Widler, P., Fisch, H.U., Schoch, P., Zimmermann, A., Schläpfer, T.E., Reichen, J. Hepatology (1993) [Pubmed]
  13. Halofuginone to prevent and treat thioacetamide-induced liver fibrosis in rats. Bruck, R., Genina, O., Aeed, H., Alexiev, R., Nagler, A., Avni, Y., Pines, M. Hepatology (2001) [Pubmed]
  14. Combination of systemic thioacetamide (TAA) injections and ethanol feeding accelerates hepatic fibrosis in C3H/He mice and is associated with intrahepatic up regulation of MMP-2, VEGF and ICAM-1. Kornek, M., Raskopf, E., Guetgemann, I., Ocker, M., Gerceker, S., Gonzalez-Carmona, M.A., Rabe, C., Sauerbruch, T., Schmitz, V. J. Hepatol. (2006) [Pubmed]
  15. Melatonin prevents experimental liver cirrhosis induced by thioacetamide in rats. Cruz, A., Padillo, F.J., Torres, E., Navarrete, C.M., Muñoz-Castañeda, J.R., Caballero, F.J., Briceño, J., Marchal, T., Túnez, I., Montilla, P., Pera, C., Muntané, J. J. Pineal Res. (2005) [Pubmed]
  16. Renal damage in experimentally-induced cirrhosis in rats: Role of oxygen free radicals. Natarajan, S.K., Basivireddy, J., Ramachandran, A., Thomas, S., Ramamoorthy, P., Pulimood, A.B., Jacob, M., Balasubramanian, K.A. Hepatology (2006) [Pubmed]
  17. Stimulated hepatic tissue repair underlies heteroprotection by thioacetamide against acetaminophen-induced lethality. Chanda, S., Mangipudy, R.S., Warbritton, A., Bucci, T.J., Mehendale, H.M. Hepatology (1995) [Pubmed]
  18. Isoenzymes of carbohydrate metabolism in primary cultures of hepatocytes from thioacetamide-induced rat liver necrosis: responses to growth factors. Cascales, M., Martin-Sanz, P., Alvarez, A., Sanchez-Pérez, M., Diez Fernández, C., Boscá, L. Hepatology (1992) [Pubmed]
  19. Relationship between genomic DNA ploidy and parameters of liver damage during necrosis and regeneration induced by thioacetamide. Díez-Fernández, C., Boscá, L., Fernández-Simón, L., Alvarez, A., Cascales, M. Hepatology (1993) [Pubmed]
  20. Changes of hepatic fatty acid metabolism produced by chronic thioacetamide administration in rats. Nozu, F., Takeyama, N., Tanaka, T. Hepatology (1992) [Pubmed]
  21. Nuclear envelope alterations accompanying thioacetamide-related enlargement of the nucleus. Clawson, G.A., Moody, D.E., James, J., Smuckler, E.A. Cancer Res. (1981) [Pubmed]
  22. Changes in fatty acid composition of plasma, liver microsomes, and erythrocytes in liver cirrhosis induced by oral intake of thioacetamide in rats. Moreira, E., Fontana, L., Periago, J.L., Sanchéz De Medina, F., Gil, A. Hepatology (1995) [Pubmed]
  23. Apparent differential response of nuclear envelope cytochrome P-450 following phenobarbital induction arising from a preferential loss during gradient purification. Clawson, G.A., Moody, D.E., Woo, C.H., Smuckler, E.A. Cancer Res. (1981) [Pubmed]
  24. alpha-Fetoprotein in toxic liver injury. Smuckler, E.A., Koplitz, M., Sell, S. Cancer Res. (1976) [Pubmed]
  25. Normal increase in glucose output by portal noradrenaline and glucagon but not nerve stimulation with enhanced portal resistance, not only in micronodular but also in intermediate thioacetamide cirrhotic livers. Gardemann, A., Zimmermann, T., Machnik, G., Dargel, R., Jungermann, K. Hepatology (1993) [Pubmed]
  26. Leptin is required for fibrogenic responses induced by thioacetamide in the murine liver. Honda, H., Ikejima, K., Hirose, M., Yoshikawa, M., Lang, T., Enomoto, N., Kitamura, T., Takei, Y., Sato, N. Hepatology (2002) [Pubmed]
  27. Thioacetamide-induced liver regeneration involves the expression of cyclooxygenase 2 and nitric oxide synthase 2 in hepatocytes. Fernández-Martínez, A., Callejas, N.A., Casado, M., Boscá, L., Martín-Sanz, P. J. Hepatol. (2004) [Pubmed]
  28. Malic enzyme and glucose 6-phosphate dehydrogenase gene expression increases in rat liver cirrhogenesis. Sanz, N., Díez-Fernández, C., Valverde, A.M., Lorenzo, M., Benito, M., Cascales, M. Br. J. Cancer (1997) [Pubmed]
  29. Augmented hepatic injury followed by impaired regeneration in metallothionein-I/II knockout mice after treatment with thioacetamide. Oliver, J.R., Jiang, S., Cherian, M.G. Toxicol. Appl. Pharmacol. (2006) [Pubmed]
  30. Expression of insulin-like growth factor-I and insulin-like growth factor binding proteins during thioacetamide-induced liver cirrhosis in rats. Novosyadlyy, R., Dargel, R., Scharf, J.G. Growth Horm. IGF Res. (2005) [Pubmed]
  31. Effect of partial hepatectomy on tumor incidence and metabolism of mice fed thioacetamide. Date, P.A., Gothoskar, S.V., Bhide, S.V. J. Natl. Cancer Inst. (1976) [Pubmed]
  32. Leptin receptor-mediated signaling regulates hepatic fibrogenesis and remodeling of extracellular matrix in the rat. Ikejima, K., Takei, Y., Honda, H., Hirose, M., Yoshikawa, M., Zhang, Y.J., Lang, T., Fukuda, T., Yamashina, S., Kitamura, T., Sato, N. Gastroenterology (2002) [Pubmed]
  33. Alteration in growth regulation of hepatocytes in primary culture obtained from cirrhotic rat: poor response to transforming growth factor-beta 1 and interferons. Kiso, S., Kawata, S., Tamura, S., Ito, N., Takaishi, K., Shirai, Y., Tsushima, H., Matsuzawa, Y. Hepatology (1994) [Pubmed]
  34. Increased activity of rat liver messenger RNA and of albumin messenger RNA modulated by thioacetamide. Chakrabartty, P.K., Schneider, W.C. Cancer Res. (1978) [Pubmed]
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