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Gene Review

THR4  -  threonine synthase THR4

Saccharomyces cerevisiae S288c

Synonyms: TS, Threonine synthase, YCR053W, YCR53W
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Disease relevance of THR4


High impact information on THR4


Biological context of THR4


Associations of THR4 with chemical compounds

  • The gene encoding threonine synthase (THR4) from the yeast Saccharomyces cerevisiae was cloned by complementation of a thr4 mutant [6].
  • These vectors may-but need not-include mutant DHFR-TS alleles that confer pyrimethamine resistance to transgenic parasites [8].
  • Upon TS inhibition, dUTP pools may accumulate, inducing repeated cycles of uracil misincorporation into DNA and repair-mediated DNA damage [9].


  1. A common origin for enzymes involved in the terminal step of the threonine and tryptophan biosynthetic pathways. Parsot, C. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  2. Mutations in Saccharomyces cerevisiae which confer resistance to several amino acid analogs. McCusker, J.H., Haber, J.E. Mol. Cell. Biol. (1990) [Pubmed]
  3. Structure and function of threonine synthase from yeast. Garrido-Franco, M., Ehlert, S., Messerschmidt, A., Marinkovic', S., Huber, R., Laber, B., Bourenkov, G.P., Clausen, T. J. Biol. Chem. (2002) [Pubmed]
  4. Nucleotide sequence of the yeast THR4 gene encoding threonine synthase. Aas, S.F., Rognes, S.E. Nucleic Acids Res. (1990) [Pubmed]
  5. A short chromosomal region with major roles in yeast chromosome III meiotic disjunction, recombination and double strand breaks. Goldway, M., Sherman, A., Zenvirth, D., Arbel, T., Simchen, G. Genetics (1993) [Pubmed]
  6. Analysis of the THR4 region on chromosome III of the yeast Saccharomyces cerevisiae. Mannhaupt, G., van der Linden, G., Vetter, I., Maurer, K., Pilz, U., Planta, R., Feldmann, H. Yeast (1990) [Pubmed]
  7. AgTHR4, a new selection marker for transformation of the filamentous fungus Ashbya gossypii, maps in a four-gene cluster that is conserved between A. gossypii and Saccharomyces cerevisiae. Altmann-Jöhl, R., Philippsen, P. Mol. Gen. Genet. (1996) [Pubmed]
  8. Tagging genes and trapping promoters in Toxoplasma gondii by insertional mutagenesis. Roos, D.S., Sullivan, W.J., Striepen, B., Bohne, W., Donald, R.G. Methods (1997) [Pubmed]
  9. The role of dUTPase and uracil-DNA repair in cancer chemotherapy. Ladner, R.D. Curr. Protein Pept. Sci. (2001) [Pubmed]
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