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MeSH Review

Terminator Regions (Genetics)

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Disease relevance of Terminator Regions (Genetics)


High impact information on Terminator Regions (Genetics)

  • In vitro the nusA gene protein causes RNA polymerase to pause in the tR2 terminator region of lambda DNA [6].
  • Here we report a physical association of promoter and terminator regions of the yeast BUD3 and SEN1 genes [7].
  • We have shown previously that the TFIIIC1/TFIIIC1' fraction interacts specifically with the VA1 terminator regions to affect both termination and initiation/reinitiation of transcription by human RNA polymerase III [8].
  • Immunodepletion with anti-NF1 antibodies dramatically decreases transcription from the VA1 template in nuclear extract, and mutation at the NF1-binding site in the terminator region of the VA1 gene selectively affects multiple-round transcription (reinitiation of transcription) and termination [8].
  • In the absence of tat, RNA polymerases are prematurely released from the template at the terminator sequence [9].

Chemical compound and disease context of Terminator Regions (Genetics)


Biological context of Terminator Regions (Genetics)


Associations of Terminator Regions (Genetics) with chemical compounds

  • The N1 fragment binds poly(C) and mRNA corresponding to the rho-dependent terminator sequence trp t', but not RNA unrecognized by rho; hence, this small renaturable domain retains not only the binding ability but also the specificity of the native protein [15].
  • Analogous to the procaryotic RNA polymerase, the eucaryotic enzyme terminated just beyond the guanine-plus-cytosine-rich region of dyad symmetry in the terminator sequence [16].
  • At 37 degrees C, cleavages occurred in an 84 bp A+T-rich sequence in the terminator region of the ampicillin-resistance gene [17].
  • Specific in vitro transcription by partially purified RNA polymerase from Methanobacterium thermoautotrophicum of DNA sequences cloned in between the promoter and terminator regions of the methyl CoM reductase transcription unit of the same organism is described [18].
  • In the presence of sucrose, SacY is activated and prevents premature termination of transcription by binding to a RNA-antiterminator (RAT) sequence partially overlapping with the terminator sequence [19].

Gene context of Terminator Regions (Genetics)

  • S1 nuclease mapping of the 3'-end of the two-cistron glyS mRNA showed that it predominantly ends 33/34 bases beyond the tandem stops with an RNA polymerse terminator sequence [20].
  • Potential promoter and terminator sequences for aspA were also found in the determined sequence [21].
  • The terminator sequence, T1, located between rpsU and dnaG is conserved at 31 positions in nine enterobacterial species, suggesting the importance of primary sequence in addition to secondary structure for transcription termination [22].
  • The protein is extremely hydrophobic. traS has its own promoter and a weak terminator region follows the gene [23].
  • In addition, pGUS2 carries the yeast ADH1 transcriptional terminator sequence upstream from gus, in order to block read-through transcription originating in vector sequences [24].


  1. Spt5 cooperates with human immunodeficiency virus type 1 Tat by preventing premature RNA release at terminator sequences. Bourgeois, C.F., Kim, Y.K., Churcher, M.J., West, M.J., Karn, J. Mol. Cell. Biol. (2002) [Pubmed]
  2. The S box regulon: a new global transcription termination control system for methionine and cysteine biosynthesis genes in gram-positive bacteria. Grundy, F.J., Henkin, T.M. Mol. Microbiol. (1998) [Pubmed]
  3. Expression of the M gene of vesicular stomatitis virus cloned in various vaccinia virus vectors. Li, Y., Luo, L.Z., Snyder, R.M., Wagner, R.R. J. Virol. (1988) [Pubmed]
  4. Polymorphism at the dnaK locus of Brucella species and identification of a Brucella melitensis species-specific marker. Cloeckaert, A., Verger, J.M., Grayon, M., Grépinet, O. J. Med. Microbiol. (1996) [Pubmed]
  5. Heterologous gene expression of the glyphosate resistance marker and its application in yeast transformation. Kunze, G., Bode, R., Rintala, H., Hofemeister, J. Curr. Genet. (1989) [Pubmed]
  6. Termination of transcription by nusA gene protein of Escherichia coli. Greenblatt, J., McLimont, M., Hanly, S. Nature (1981) [Pubmed]
  7. A role for the CPF 3'-end processing machinery in RNAP II-dependent gene looping. Ansari, A., Hampsey, M. Genes Dev. (2005) [Pubmed]
  8. Nuclear factor 1 (NF1) affects accurate termination and multiple-round transcription by human RNA polymerase III. Wang, Z., Bai, L., Hsieh, Y.J., Roeder, R.G. EMBO J. (2000) [Pubmed]
  9. Human immunodeficiency virus type 1 transactivator protein, tat, stimulates transcriptional read-through of distal terminator sequences in vitro. Graeble, M.A., Churcher, M.J., Lowe, A.D., Gait, M.J., Karn, J. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  10. Electrotransformation and expression of bacterial genes encoding hygromycin phosphotransferase and beta-galactosidase in the pathogenic fungus Histoplasma capsulatum. Woods, J.P., Heinecke, E.L., Goldman, W.E. Infect. Immun. (1998) [Pubmed]
  11. Role of the 3' untranslated region of baculovirus p10 mRNA in high-level expression of foreign genes. van Oers, M.M., Vlak, J.M., Voorma, H.O., Thomas, A.A. J. Gen. Virol. (1999) [Pubmed]
  12. Expression of lacZ gene fusions affects downstream transcription in yeast. Barnes, C.A., Johnston, G.C., Singer, R.A. Gene (1991) [Pubmed]
  13. Analysis of the THR4 region on chromosome III of the yeast Saccharomyces cerevisiae. Mannhaupt, G., van der Linden, G., Vetter, I., Maurer, K., Pilz, U., Planta, R., Feldmann, H. Yeast (1990) [Pubmed]
  14. Positive control of Pseudomonas aeruginosa amidase synthesis is mediated by a transcription anti-termination mechanism. Drew, R., Lowe, N. J. Gen. Microbiol. (1989) [Pubmed]
  15. Structure of rho factor: an RNA-binding domain and a separate region with strong similarity to proven ATP-binding domains. Dombroski, A.J., Platt, T. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  16. Pausing and termination of human RNA polymerase II transcription at a procaryotic terminator. Hatfield, G.W., Sharp, J.A., Rosenberg, M. Mol. Cell. Biol. (1983) [Pubmed]
  17. Altered DNA conformations detected by mung bean nuclease occur in promoter and terminator regions of supercoiled pBR322 DNA. Sheflin, L.G., Kowalski, D. Nucleic Acids Res. (1985) [Pubmed]
  18. Specific transcription of cloned Methanobacterium thermoautotrophicum transcription units by homologous RNA polymerase in vitro. Knaub, S., Klein, A. Nucleic Acids Res. (1990) [Pubmed]
  19. Crystallization of the RNA-binding domain of the transcriptional antiterminator protein SacY from Bacillus subtilis. Manival, X., Aymerich, S., Strub, M.P., Dumas, C., Kochoyan, M., van Tilbeurgh, H. Proteins (1997) [Pubmed]
  20. Primary structures of both subunits of Escherichia coli glycyl-tRNA synthetase. Webster, T.A., Gibson, B.W., Keng, T., Biemann, K., Schimmel, P. J. Biol. Chem. (1983) [Pubmed]
  21. Cloning and nucleotide sequence of the aspartase gene of Escherichia coli W. Takagi, J.S., Ida, N., Tokushige, M., Sakamoto, H., Shimura, Y. Nucleic Acids Res. (1985) [Pubmed]
  22. Conservation and evolution of the rpsU-dnaG-rpoD macromolecular synthesis operon in bacteria. Versalovic, J., Koeuth, T., Britton, R., Geszvain, K., Lupski, J.R. Mol. Microbiol. (1993) [Pubmed]
  23. Surface exclusion genes traS and traT of the F sex factor of Escherichia coli K-12. Determination of the nucleotide sequence and promoter and terminator activities. Jalajakumari, M.B., Guidolin, A., Buhk, H.J., Manning, P.A., Ham, L.M., Hodgson, A.L., Cheah, K.C., Skurray, R.A. J. Mol. Biol. (1987) [Pubmed]
  24. Vectors with the gus reporter gene for identifying and quantitating promoter regions in Saccharomyces cerevisiae. Marathe, S.V., McEwen, J.E. Gene (1995) [Pubmed]
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