The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

TPO1  -  Tpo1p

Saccharomyces cerevisiae S288c

Synonyms: L0939, Polyamine transporter 1, YLL028W
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on TPO1


Biological context of TPO1

  • Although the protective role of TPO1 and PDR5 genes was confirmed, the majority of the responsive genes encoding multidrug resistance do not confer resistance to 2,4-D [3].
  • Deletion analysis of these genes demonstrated that TPO1 and SLK19 specifically regulated ERG9 expression when tested with several different promoter-reporter gene fusions [4].
  • The longer duration of the adaptation period, observed for the Delta(pdr1) population, may involve the abolishment of the Pdr1p-mediated transcriptional activation of TPO1 and PDR5 genes, whose expression is critical to surpass the viability loss during the initial period of adaptation to the herbicides [5].
  • A rapid and transient activation of TPO1 (sixfold) and PDR5 (twofold) transcription takes place during the adaptation period preceding cell division under MCPA or 2,4-D moderate stress [5].

Associations of TPO1 with chemical compounds

  • The drug sensitivity of the strains deleted for these genes revealed that TPO1, a gene previously found to be involved in spermidine resistance and vacuolar polyamine transport, is a determinant of multidrug transporter since it also mediates growth resistance to cycloheximide and quinidine [6].
  • Novel target genes of the yeast regulator Pdr1p: a contribution of the TPO1 gene in resistance to quinidine and other drugs [6].
  • Both YOR273C and TPO1 as well as at least one other determinant involved in the yeast pleiotropic drug resistance network contribute to resistance to a quinoline-containing antimalarial drug [6].
  • We screened for Saccharomyces cerevisiae genes whose overexpression causes indomethacin resistance and identified the TPO1 gene, which encodes a major facilitator superfamily transporter [7].
  • Identification of the TPO1 gene in yeast, and its human orthologue TETRAN, which cause resistance to NSAIDs [7].

Regulatory relationships of TPO1

  • Additionally, EMSAs demonstrated that extracts derived from the TPO1 deletion strain was unable to shift the repressing cis-element while protein extracts from the SLK19 deletion strain had a reduced shift of the activating cis-element [4].

Other interactions of TPO1

  • Expression of TPO1 and/or IMD2 was strongly affected in 16 such transcription mutants suggesting that low expression of these genes could contribute to MPA sensitivity [8].


  1. Characteristics of the polyamine transporter TPO1 and regulation of its activity and cellular localization by phosphorylation. Uemura, T., Tachihara, K., Tomitori, H., Kashiwagi, K., Igarashi, K. J. Biol. Chem. (2005) [Pubmed]
  2. Localization and function of the yeast multidrug transporter Tpo1p. Albertsen, M., Bellahn, I., Krämer, R., Waffenschmidt, S. J. Biol. Chem. (2003) [Pubmed]
  3. Early transcriptional response of Saccharomyces cerevisiae to stress imposed by the herbicide 2,4-dichlorophenoxyacetic acid. Teixeira, M.C., Fernandes, A.R., Mira, N.P., Becker, J.D., Sá-Correia, I. FEMS Yeast Res. (2006) [Pubmed]
  4. Positive and negative regulation of squalene synthase (ERG9), an ergosterol biosynthetic gene, in Saccharomyces cerevisiae. Kennedy, M.A., Bard, M. Biochim. Biophys. Acta (2001) [Pubmed]
  5. Saccharomyces cerevisiae resistance to chlorinated phenoxyacetic acid herbicides involves Pdr1p-mediated transcriptional activation of TPO1 and PDR5 genes. Teixeira, M.C., Sá-Correia, I. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  6. Novel target genes of the yeast regulator Pdr1p: a contribution of the TPO1 gene in resistance to quinidine and other drugs. do Valle Matta, M.A., Jonniaux, J.L., Balzi, E., Goffeau, A., van den Hazel, B. Gene (2001) [Pubmed]
  7. Identification of the TPO1 gene in yeast, and its human orthologue TETRAN, which cause resistance to NSAIDs. Mima, S., Ushijima, H., Hwang, H.J., Tsutsumi, S., Makise, M., Yamaguchi, Y., Tsuchiya, T., Mizushima, H., Mizushima, T. FEBS Lett. (2007) [Pubmed]
  8. Screening the yeast "disruptome" for mutants affecting resistance to the immunosuppressive drug, mycophenolic acid. Desmoucelles, C., Pinson, B., Saint-Marc, C., Daignan-Fornier, B. J. Biol. Chem. (2002) [Pubmed]
WikiGenes - Universities