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Gene Review

REC104  -  Rec104p

Saccharomyces cerevisiae S288c

Synonyms: Meiotic recombination protein REC104, YHR157W
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High impact information on REC104


Biological context of REC104

  • We find that mutations in any of three Early Exchange genes (REC104, REC114 or REC102) confer a phenotype in which the reductional division occurs earlier than in an isogenic wild-type diploid [5].
  • The second suppressor maps to the right arm of chromosome VIII distal to CDC12 and is REC104, a meiosis-specific gene believed to act early in meiosis [6].
  • Overexpression of REC104 from a 2 mu plasmid was shown to enhance the spore viability of every allele tested, including a hop1 disruption allele [7].
  • The REC104 gene has no apparent role in mitosis, since mutations have no observable effect on growth, mitotic recombination, or DNA repair [8].
  • The DNA sequence of REC104 reveals that it is a previously unknown gene with a coding region of 549-bp, and genetic mapping has localized the gene to chromosome VIII near FUR1 [8].

Regulatory relationships of REC104

  • An increased dosage of the early exchange gene REC102 was found to suppress the conditional recombinational reduction in rec104-8 as well as in several other conditional rec104 alleles [3].

Other interactions of REC104

  • However, no suppression was observed for a null allele of REC104, indicating that the suppression by REC102 is not "bypass" suppression [3].
  • We demonstrate that a mutation in a gene (REC104) required for initiation of exchange is completely epistatic to a mutation in RED1 [9].
  • The rec104 mutation is epistatic to the mei4 mutation for the timing of the first division [5].
  • The REC104 gene was initially defined by mutations that rescued the inviability of a rad52 spo 13 haploid strain in meiosis [8].


  1. Spatial organization and dynamics of the association of Rec102 and Rec104 with meiotic chromosomes. Kee, K., Protacio, R.U., Arora, C., Keeney, S. EMBO J. (2004) [Pubmed]
  2. Support for a meiotic recombination initiation complex: interactions among Rec102p, Rec104p, and Spo11p. Jiao, K., Salem, L., Malone, R. Mol. Cell. Biol. (2003) [Pubmed]
  3. Suppressor analysis of the Saccharomyces cerevisiae gene REC104 reveals a genetic interaction with REC102. Salem, L., Walter, N., Malone, R. Genetics (1999) [Pubmed]
  4. Coordination of the initiation of recombination and the reductional division in meiosis in Saccharomyces cerevisiae. Jiao, K., Bullard, S.A., Salem, L., Malone, R.E. Genetics (1999) [Pubmed]
  5. Recombination and the progression of meiosis in Saccharomyces cerevisiae. Galbraith, A.M., Bullard, S.A., Jiao, K., Nau, J.J., Malone, R.E. Genetics (1997) [Pubmed]
  6. A conditional allele of the Saccharomyces cerevisiae HOP1 gene is suppressed by overexpression of two other meiosis-specific genes: RED1 and REC104. Hollingsworth, N.M., Johnson, A.D. Genetics (1993) [Pubmed]
  7. Insertional mutations in the yeast HOP1 gene: evidence for multimeric assembly in meiosis. Friedman, D.B., Hollingsworth, N.M., Byers, B. Genetics (1994) [Pubmed]
  8. Characterization of REC104, a gene required for early meiotic recombination in the yeast Saccharomyces cerevisiae. Galbraith, A.M., Malone, R.E. Dev. Genet. (1992) [Pubmed]
  9. Analysis of meiotic recombination pathways in the yeast Saccharomyces cerevisiae. Mao-Draayer, Y., Galbraith, A.M., Pittman, D.L., Cool, M., Malone, R.E. Genetics (1996) [Pubmed]
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