Gene Review:
MEK1 - Mek1p
Saccharomyces cerevisiae S288c
Synonyms:
MRE4, Meiosis-specific serine/threonine-protein kinase MEK1, O6357, YOR351C
- Mechanistic link between the anti-HCV effect of interferon gamma and control of viral replication by a Ras-MAPK signaling cascade. Huang, Y., Chen, X.C., Konduri, M., Fomina, N., Lu, J., Jin, L., Kolykhalov, A., Tan, S.L. Hepatology (2006)
- Pachytene exit controlled by reversal of Mek1-dependent phosphorylation. Bailis, J.M., Roeder, G.S. Cell (2000)
- Stimulatory effects of yeast and mammalian 14-3-3 proteins on the Raf protein kinase. Irie, K., Gotoh, Y., Yashar, B.M., Errede, B., Nishida, E., Matsumoto, K. Science (1994)
- Red1p, a MEK1-dependent phosphoprotein that physically interacts with Hop1p during meiosis in yeast. de los Santos, T., Hollingsworth, N.M. J. Biol. Chem. (1999)
- Meiotic cells monitor the status of the interhomolog recombination complex. Xu, L., Weiner, B.M., Kleckner, N. Genes Dev. (1997)
- Partner choice during meiosis is regulated by Hop1-promoted dimerization of Mek1. Niu, H., Wan, L., Baumgartner, B., Schaefer, D., Loidl, J., Hollingsworth, N.M. Mol. Biol. Cell (2005)
- RAS signalling is abnormal in a c-raf1 MEK1 double mutant. Bottorff, D., Stang, S., Agellon, S., Stone, J.C. Mol. Cell. Biol. (1995)
- Bub1 is activated by the protein kinase p90(Rsk) during Xenopus oocyte maturation. Schwab, M.S., Roberts, B.T., Gross, S.D., Tunquist, B.J., Taieb, F.E., Lewellyn, A.L., Maller, J.L. Curr. Biol. (2001)
- Mkh1, a MEK kinase required for cell wall integrity and proper response to osmotic and temperature stress in Schizosaccharomyces pombe. Sengar, A.S., Markley, N.A., Marini, N.J., Young, D. Mol. Cell. Biol. (1997)
- The MEK kinase Ssk2p promotes actin cytoskeleton recovery after osmotic stress. Yuzyuk, T., Foehr, M., Amberg, D.C. Mol. Biol. Cell (2002)
- Rad3-Cds1 mediates coupling of initiation of meiotic recombination with DNA replication. Mei4-dependent transcription as a potential target of meiotic checkpoint. Ogino, K., Masai, H. J. Biol. Chem. (2006)
- The MRE4 gene encodes a novel protein kinase homologue required for meiotic recombination in Saccharomyces cerevisiae. Leem, S.H., Ogawa, H. Nucleic Acids Res. (1992)
- Mek1 kinase activity functions downstream of RED1 in the regulation of meiotic double strand break repair in budding yeast. Wan, L., de los Santos, T., Zhang, C., Shokat, K., Hollingsworth, N.M. Mol. Biol. Cell (2004)
- Bypass of a meiotic checkpoint by overproduction of meiotic chromosomal proteins. Bailis, J.M., Smith, A.V., Roeder, G.S. Mol. Cell. Biol. (2000)
- A meiosis-specific protein kinase homolog required for chromosome synapsis and recombination. Rockmill, B., Roeder, G.S. Genes Dev. (1991)
- Synaptonemal complex morphogenesis and sister-chromatid cohesion require Mek1-dependent phosphorylation of a meiotic chromosomal protein. Bailis, J.M., Roeder, G.S. Genes Dev. (1998)