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Gene Review

COS7  -  Cos7p

Saccharomyces cerevisiae S288c

Synonyms: Protein COS7, YDL248W
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High impact information on COS7


Biological context of COS7

  • Possible interactions between ICA512/IA-2 and components of the cytoskeleton were not supported by studies on staining of fixed yeast cells with phalloidin-Texas Red. With transfected mammalian cell lines COS-7 and NIH3T3, expression of ICA512/IA-2 likewise induced growth arrest, with some of the morphological features of apoptosis [6].

Anatomical context of COS7

  • We directly demonstrated that plasmin cleaves these same sites in full-length membrane-embedded receptor expressed in yeast and COS7 fibroblasts [7].
  • Processing of mutated proinsulin with tetrabasic cleavage sites to bioactive insulin in the non-endocrine cell line, COS-7 [8].
  • When cDNA for cauliflower cyt b5 was introduced into mammalian (COS-7) and yeast cells as well as into onion cells, the expressed cytochrome was localized both in the ER and mitochondria in those cells [9].

Associations of COS7 with chemical compounds


Analytical, diagnostic and therapeutic context of COS7


  1. The human 37-kDa laminin receptor precursor interacts with the prion protein in eukaryotic cells. Rieger, R., Edenhofer, F., Lasmézas, C.I., Weiss, S. Nat. Med. (1997) [Pubmed]
  2. G alpha12 interaction with alphaSNAP induces VE-cadherin localization at endothelial junctions and regulates barrier function. Andreeva, A.V., Kutuzov, M.A., Vaiskunaite, R., Profirovic, J., Meigs, T.E., Predescu, S., Malik, A.B., Voyno-Yasenetskaya, T. J. Biol. Chem. (2005) [Pubmed]
  3. Identification and characterization of AGS4: a protein containing three G-protein regulatory motifs that regulate the activation state of Gialpha. Cao, X., Cismowski, M.J., Sato, M., Blumer, J.B., Lanier, S.M. J. Biol. Chem. (2004) [Pubmed]
  4. Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes. Haft, C.R., de la Luz Sierra, M., Bafford, R., Lesniak, M.A., Barr, V.A., Taylor, S.I. Mol. Biol. Cell (2000) [Pubmed]
  5. The functional cooperation of MAP1A heavy chain and light chain 2 in the binding of microtubules. Chien, C.L., Lu, K.S., Lin, Y.S., Hsieh, C.J., Hirokawa, N. Exp. Cell Res. (2005) [Pubmed]
  6. Expression of protein tyrosine phosphatase-like molecule ICA512/IA-2 induces growth arrest in yeast cells and transfected mammalian cell lines. Papakonstantinou, T., Myers, M.A., Jois, J., Roucou, X., Prescott, M., Rowley, M.J., Mackay, I.R. J. Autoimmun. (2001) [Pubmed]
  7. Plasmin desensitization of the PAR1 thrombin receptor: kinetics, sites of truncation, and implications for thrombolytic therapy. Kuliopulos, A., Covic, L., Seeley, S.K., Sheridan, P.J., Helin, J., Costello, C.E. Biochemistry (1999) [Pubmed]
  8. Processing of mutated proinsulin with tetrabasic cleavage sites to bioactive insulin in the non-endocrine cell line, COS-7. Yanagita, M., Nakayama, K., Takeuchi, T. FEBS Lett. (1992) [Pubmed]
  9. Dual subcellular distribution of cytochrome b5 in plant, cauliflower, cells. Zhao, J., Onduka, T., Kinoshita, J.Y., Honsho, M., Kinoshita, T., Shimazaki, K., Ito, A. J. Biochem. (2003) [Pubmed]
  10. Production of bioactive enkephalin from the nonendocrine cell lines COS-7, NIH3T3, Ltk-, and C2C12. Takahashi, K., Fujita, T., Takeuchi, T. Peptides (1995) [Pubmed]
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