The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Map1a  -  microtubule-associated protein 1 A

Mus musculus

Synonyms: 6330416M19Rik, AI853608, MAP-1A, Microtubule-associated protein 1A, Mtap-1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Mtap1a


High impact information on Mtap1a


Biological context of Mtap1a


Anatomical context of Mtap1a


Associations of Mtap1a with chemical compounds

  • Data collected from yeast two-hybrid assays of various MAP1A domains confirmed that the interaction of LC2 and NH2-terminal of MAP1A heavy chain is important for microtubule binding [8].
  • Here, we identified, by double-immunofluorescent labeling, MAP1A isoform and serotonin 5-HT(2A) receptor distribution [9].

Other interactions of Mtap1a


Analytical, diagnostic and therapeutic context of Mtap1a


  1. Microtubule-associated protein 1A is a modifier of tubby hearing (moth1). Ikeda, A., Zheng, Q.Y., Zuberi, A.R., Johnson, K.R., Naggert, J.K., Nishina, P.M. Nat. Genet. (2002) [Pubmed]
  2. Genetic modification of retinal degeneration in tubby mice. Ikeda, A., Naggert, J.K., Nishina, P.M. Exp. Eye Res. (2002) [Pubmed]
  3. Somatostatin receptors in wildtype and somatostatin deficient mice and their involvement in nitric oxide physiology in the retina. Mastrodimou, N., Vasilaki, A., Papadioti, A., Low, M.J., Hoyer, D., Thermos, K. Neuropeptides (2006) [Pubmed]
  4. Synthesis, axonal transport, and turnover of the high molecular weight microtubule-associated protein MAP 1A in mouse retinal ganglion cells: tubulin and MAP 1A display distinct transport kinetics. Nixon, R.A., Fischer, I., Lewis, S.E. J. Cell Biol. (1990) [Pubmed]
  5. A casein kinase II-related activity is involved in phosphorylation of microtubule-associated protein MAP-1B during neuroblastoma cell differentiation. Díaz-Nido, J., Serrano, L., Méndez, E., Avila, J. J. Cell Biol. (1988) [Pubmed]
  6. Genetic modification of hearing in tubby mice: evidence for the existence of a major gene (moth1) which protects tubby mice from hearing loss. Ikeda, A., Zheng, Q.Y., Rosenstiel, P., Maddatu, T., Zuberi, A.R., Roopenian, D.C., North, M.A., Naggert, J.K., Johnson, K.R., Nishina, P.M. Hum. Mol. Genet. (1999) [Pubmed]
  7. Microtubule-associated protein 1A is the fibroblast HMW MAP undergoing mitogen-stimulated serine phosphorylation. Erickson, A.K., Ray, L.B., Sturgill, T.W. Biochem. Biophys. Res. Commun. (1990) [Pubmed]
  8. The functional cooperation of MAP1A heavy chain and light chain 2 in the binding of microtubules. Chien, C.L., Lu, K.S., Lin, Y.S., Hsieh, C.J., Hirokawa, N. Exp. Cell Res. (2005) [Pubmed]
  9. Differential distribution of MAP1A isoforms in the adult mouse barrel cortex and comparison with the serotonin 5-HT2A receptor. Touri, F., Welker, E., Riederer, B.M. J. Chem. Neuroanat. (2004) [Pubmed]
  10. Identification of high molecular weight microtubule-associated proteins in anterior pituitary tissue and cells using taxol-dependent purification combined with microtubule-associated protein specific antibodies. Bloom, G.S., Luca, F.C., Vallee, R.B. Biochemistry (1985) [Pubmed]
WikiGenes - Universities