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Gene Review

NRP1  -  Nrp1p

Saccharomyces cerevisiae S288c

Synonyms: ARP, ARP1, Asparagine-rich protein, Protein ARP, YDL167C
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High impact information on NRP1

  • Using solid-state NMR we have examined the structure of amyloid fibrils formed in vitro from purified recombinant Sup35(1-253), consisting of the glutamine- and asparagine-rich N-terminal 123-residue prion domain (N) and the adjacent 130-residue highly charged M domain [1].
  • In solution at acid pH, the glutamine-rich and asparagine-rich 18-residue Sup35 peptide, rendered soluble by the addition of two aspartates at the amino end and two lysines at the carboxyl end, gives a beta-sheet CD spectrum; it aggregates at neutral pH [2].
  • The C-terminal domain of Ure2p controls nitrogen catabolism by complexing with the transcription factor, Gln3p, whereas the asparagine-rich N-terminal "prion" domain is responsible for amyloid filament formation (prion conversion) [3].
  • The gene for PUB1 was cloned and sequenced, and the sequence was found to predict a 51-kDa protein with three ribonucleoprotein consensus RNA-binding domains and three glutamine- and asparagine-rich auxiliary domains [4].
  • Therefore the genes are proposed to be named AZF1 (asparagine-rich zinc-finger protein) and PGD1 (polyglutamine domain protein) [5].

Associations of NRP1 with chemical compounds


Other interactions of NRP1


  1. Amyloid of the prion domain of Sup35p has an in-register parallel beta-sheet structure. Shewmaker, F., Wickner, R.B., Tycko, R. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  2. Aggregation of proteins with expanded glutamine and alanine repeats of the glutamine-rich and asparagine-rich domains of Sup35 and of the amyloid beta-peptide of amyloid plaques. Perutz, M.F., Pope, B.J., Owen, D., Wanker, E.E., Scherzinger, E. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  3. Mechanism of inactivation on prion conversion of the Saccharomyces cerevisiae Ure2 protein. Baxa, U., Speransky, V., Steven, A.C., Wickner, R.B. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  4. PUB1: a major yeast poly(A)+ RNA-binding protein. Matunis, M.J., Matunis, E.L., Dreyfuss, G. Mol. Cell. Biol. (1993) [Pubmed]
  5. A new nuclear suppressor system for a mitochondrial RNA polymerase mutant identifies an unusual zinc-finger protein and a polyglutamine domain protein in Saccharomyces cerevisiae. Bröhl, S., Lisowsky, T., Riemen, G., Michaelis, G. Yeast (1994) [Pubmed]
  6. A census of glutamine/asparagine-rich regions: implications for their conserved function and the prediction of novel prions. Michelitsch, M.D., Weissman, J.S. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  7. Sequence of a segment of yeast chromosome II shows two novel genes, one almost entirely hydrophobic and the other extremely asparagine-serine rich. Cusick, M.E. Yeast (1994) [Pubmed]
  8. Azf1p is a nuclear-localized zinc-finger protein that is preferentially expressed under non-fermentative growth conditions in Saccharomyces cerevisiae. Stein, T., Kricke, J., Becher, D., Lisowsky, T. Curr. Genet. (1998) [Pubmed]
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